Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Dmitri V. Gnatenko"'
Publikováno v:
Data in Brief, Vol 36, Iss , Pp 107080- (2021)
Genetic pathways regulating hematopoietic lineage commitment at critical stages of development remain incompletely characterized. To better delineate genetic sources of variability regulating cellular speciation during steady-state hematopoiesis, we
Externí odkaz:
https://doaj.org/article/4ccd16b1804346d085633681de5f2b23
Autor:
Wei Zhu, Alexander Jares, Natasha M. Nesbitt, Wadie F. Bahou, Yupo Ma, Dmitri V. Gnatenko, Zhaoyan Liu, Lisa E. Malone
Publikováno v:
Free Radic Biol Med
Cytoprotective mechanisms of heme oxygenases function by derivatizing heme to generate carbon monoxide, ferrous iron, and isomeric biliverdins, followed by rapid NAD(P)H-dependent biliverdin reduction to the antioxidant bilirubin using two non-overla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f510f42415fba499fe9a234f6b1b989
https://doi.org/10.1016/j.freeradbiomed.2020.12.015
https://doi.org/10.1016/j.freeradbiomed.2020.12.015
Autor:
Amr M Ghaleb, Agnieszka B Bialkowska, Ashley J Snider, Dmitri V Gnatenko, Yusuf A Hannun, Vincent W Yang, Valentina A Schmidt
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129314 (2015)
IQ motif-containing GTPase-activating protein 2 (IQGAP2) is a multidomain scaffolding protein that plays a role in cytoskeleton regulation by juxtaposing Rho GTPase and Ca2+/calmodulin signals. While IQGAP2 suppresses tumorigenesis in liver, its role
Externí odkaz:
https://doaj.org/article/e1e963824a714414990feb147a2811a1
Autor:
Dmitri V. Gnatenko, Zhaoyan Liu, Patrick Hearing, Sook-Young Sohn, Yetao Hu, Anna Falanga, Song Wu, Lisa E. Malone, Wei Zhu, Wadie F. Bahou
Publikováno v:
Blood advances. 6(16)
Inflammatory stimuli have divergent effects on peripheral platelet counts, although the mechanisms of thrombocytopenic and thrombocytotic responses remain poorly understood. A candidate gene approach targeting 326 polymorphic genes enriched in thromb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0eb4ba29e1aca0ba44663b89b0b334
https://pubmed.ncbi.nlm.nih.gov/35381074
https://pubmed.ncbi.nlm.nih.gov/35381074
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71826 (2013)
It is broadly accepted that genetically engineered animal models do not always recapitulate human pathobiology. Therefore identifying best-fit mouse models of human cancers that truly reflect the corresponding human disease is of vital importance in
Externí odkaz:
https://doaj.org/article/54730d45e285463997d5d4437d88405a
Autor:
Markus A. Seeliger, Seamus Browne, Zongdong Li, Timothy J. Mantle, Wadie F. Bahou, Wen-Ting Chu, Jin Wang, Beibei Zhang, Dmitri V. Gnatenko, Natasha M. Nesbitt
Publikováno v:
Chemistry - A European Journal. 23:1891-1900
Biliverdin reductase IXβ (BLVRB) is a crucial enzyme in heme metabolism. Recent studies in humans have identified a loss-of-function mutation (Ser111Leu) that unmasks a fundamentally important role in hematopoiesis. We have undertaken experimental a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c591d4aa2fc6426bcc34875188fdd804
https://doi.org/10.1002/chem.201604517
https://doi.org/10.1002/chem.201604517
Autor:
Lisa E. Malone, Dmitri V. Gnatenko, Wadie F. Bahou, Beibei Zhang, Zongdong Li, Lu Zhao, Nedialka G. Markova, Song Wu, Timothy J. Mantle, Natasha M. Nesbitt
Publikováno v:
Blood. 128:699-709
Human blood cell counts are tightly maintained within narrow physiologic ranges, largely controlled by cytokine-integrated signaling and transcriptional circuits that regulate multilineage hematopoietic specification. Known genetic loci influencing b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b341c14864a0ed60c81fb3f4868ebc
https://doi.org/10.1182/blood-2016-02-696997
https://doi.org/10.1182/blood-2016-02-696997
Publikováno v:
Platelets in Thrombotic and Non-Thrombotic Disorders ISBN: 9783319474601
Normal function of blood platelets is a complex multistep process that is crucial for maintenance of hemostasis and wound healing. Abnormality of platelet function may cause bleeding or thrombosis and may result in death. Platelet function is regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a97b4bdec0e3b5a7713e8bcccb155b56
https://doi.org/10.1007/978-3-319-47462-5_70
https://doi.org/10.1007/978-3-319-47462-5_70
Publikováno v:
Platelets in Thrombotic and Non-Thrombotic Disorders ISBN: 9783319474601
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ea63023eba7c1e128f330b4f50aa8a8
https://doi.org/10.1007/978-3-319-47462-5_16
https://doi.org/10.1007/978-3-319-47462-5_16
Autor:
Dmitri V. Gnatenko
Publikováno v:
Drug Development Research. 74:413-417
Preclinical Research Thrombocytosis is a condition characterized by excessive numbers of platelets in blood. Chronic myeloproliferative diseases—including essential thrombocythemia—are among potential causes of high platelet count. Thrombosis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12da92e7337c71511dc687a771d4f79c
https://doi.org/10.1002/ddr.21098
https://doi.org/10.1002/ddr.21098