Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Dmitri V. Debabov"'
Autor:
Dmitri V. Debabov, Maria D. Debabova
Publikováno v:
Microbiology Independent Research Journal, Vol 5, Iss 1, Pp 29-31 (2018)
The development of a new medicine is a process that requires enormous time and tremendous financing. It takes 10-15 years from the discovery of an active compound to the launch of its production and the start of drug marketing with the total costs of
Externí odkaz:
https://doaj.org/article/827e6ef78e0542888ae09b51efcdc523
Autor:
Gordon C. Kresheck, Brian F. Volkman, Dmitri V. Debabov, Edwin Rivera, Qunying Zhang, Francis C. Neuhaus
Publikováno v:
Biochemistry. 40:7964-7972
The D-alanylation of lipoteichoic acid (LTA) allows the Gram-positive organism to modulate its surface charge, regulate ligand binding, and control the electromechanical properties of the cell wall. The incorporation of D-alanine into LTA requires th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2669be5819a67ca64cf2cedee991d929
https://doi.org/10.1021/bi010355a
https://doi.org/10.1021/bi010355a
In Staphylococcus aureus RN4220, lipoteichoic acid (LTA) is anchored in the membrane by a diglucosyldiacylglycerol moiety. The gene ( ypfP ) which encodes diglucosyldiacylglycerol synthase was recently cloned from Bacillus subtilis and expressed in E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa911dee59d3132340dd85397e2b17a
https://europepmc.org/articles/PMC99649/
https://europepmc.org/articles/PMC99649/
Autor:
Arnold S. Bleiweis, I. R. Hamilton, Dennis G. Cvitkovitch, Francis C. Neuhaus, David A. Boyd, Dmitri V. Debabov, Michael Y. Kiriukhin
Publikováno v:
Journal of bacteriology. 182(21)
In the cariogenic organism, Streptococcus mutans , low pH induces an acid tolerance response (ATR). To identify acid-regulated proteins comprising the ATR, transposon mutagenesis with the thermosensitive plasmid pGh9:IS S1 was used to produce clones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a176283844c86a28c8e7bcf61595e99b
https://pubmed.ncbi.nlm.nih.gov/11029425
https://pubmed.ncbi.nlm.nih.gov/11029425
Publikováno v:
Journal of bacteriology. 182(10)
The dlt operon ( dltA to dltD ) of Lactobacillus rhamnosus 7469 encodes four proteins responsible for the esterification of lipoteichoic acid (LTA) by d -alanine. These esters play an important role in controlling the net anionic charge of the poly (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f169309422c10db1a0e6c96cd90f484
https://pubmed.ncbi.nlm.nih.gov/10781555
https://pubmed.ncbi.nlm.nih.gov/10781555
Autor:
Daniel L. Clemans, Michael P. Heaton, Dmitri V. Debabov, Holly Sakone, R. Dwayne Lunsford, Paul E. Kolenbrander, Catherine J. Whittaker, Francis C. Neuhaus, Qunying Zhang
Publikováno v:
Infection and immunity. 67(5)
Most human oral viridans streptococci participate in intrageneric coaggregations, the cell-to-cell adherence among genetically distinct streptococci. Two genes relevant to these intrageneric coaggregations were identified by transposon Tn 916 mutagen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1470ef3b8e9a1dafcef0f6f21b8662a0
https://pubmed.ncbi.nlm.nih.gov/10225909
https://pubmed.ncbi.nlm.nih.gov/10225909
Autor:
Qunying Zhang, Michael P. Heaton, Dmitri V. Debabov, Ralph H. Lambalot, Francis C. Neuhaus, K D Stewart
Publikováno v:
Journal of bacteriology. 178(13)
The incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid in Lactobacillus casei requires the 56-kDa D-alanine-D-alanyl carrier protein ligase (Dcl) and the 8.9-kDa D-alanyl carrier protein (Dcp). To identify and isolate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fce80f4fd8010bd54033c2cddf5f9f3
https://pubmed.ncbi.nlm.nih.gov/8682792
https://pubmed.ncbi.nlm.nih.gov/8682792
Publikováno v:
Microbial drug resistance (Larchmont, N.Y.). 2(1)
The d-alanine incorporation system allows Lactobacillus casei to modulate the chemical properties of lipoteichoic acid (LTA) and hence control its proposed functions, i.e., regulation of autolysin action, metal ion binding, and the electromechanical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88f7544bd40c17b993b5cd7f2d434df
https://pubmed.ncbi.nlm.nih.gov/9158726
https://pubmed.ncbi.nlm.nih.gov/9158726