Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Dmitri V, Filippov"'
Autor:
Zhengrui Zhang, Jiaqi Fu, Johannes Gregor Matthias Rack, Chuang Li, Jim Voorneveld, Dmitri V. Filippov, Ivan Ahel, Zhao-Qing Luo, Chittaranjan Das
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract ADP-ribosylation is a reversible post-translational modification involved in various cellular activities. Removal of ADP-ribosylation requires (ADP-ribosyl)hydrolases, with macrodomain enzymes being a major family in this category. The patho
Externí odkaz:
https://doaj.org/article/2d8b55c4454d4bd7aaf78df2b4770191
Autor:
Elena Tondini, Niels R. M. Reintjens, Giulia Castello, Tsolere Arakelian, Marjolein Isendoorn, Marcel Camps, Jana Vree, Gijs A. van der Marel, Dmitri V. Filippov, Jeroen D. C. Codee, Ferry Ossendorp
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-11 (2022)
Abstract Adjuvants play a determinant role in cancer vaccination by optimally activating APCs and shaping the T cell response. Bacterial-derived lipid A is one of the most potent immune-stimulators known, and is recognized via Toll-like receptor 4 (T
Externí odkaz:
https://doaj.org/article/378b71604d3d4305b3e48e3360488c9f
Autor:
Alex van der Ham, Xue Liu, Dario Calvani, Adéla Melcrová, Melania Kozdra, Francesco Buda, Herman S. Overkleeft, Wouter H. Roos, Dmitri V. Filippov, Grégory F. Schneider
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
Molecularly thin films are important in material sciences but their use in a wide range of applications requires control over their chemical functionalities, which is difficult to achieve. Here, the authors use decacyclene to form such freestanding a
Externí odkaz:
https://doaj.org/article/46885119125844f5b59529265f89e133
Autor:
Hans Gelderblom, Sjoerd H van der Burg, Ferry Ossendorp, Peggy J de Vos van Steenwijk, Mariette I E van Poelgeest, Inge Roozen, Willem-Jan Krebber, Cornelis J M Melief, Frank M Speetjens, Marij J P Welters, Nikki M Loof, Sanne Boekestijn, Catharina A H Janssen, Marije Slingerland, Gijs G Zom, A Rob P M Valentijn, Nico J Meeuwenoord, Gijs A van der Marel, Dmitri V Filippov
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 10 (2022)
Background Amplivant is a molecularly optimized Toll-like receptor 2 ligand that can be covalently conjugated to tumor peptide antigens. In preclinical models, amplivant-adjuvanted synthetic long peptides (SLPs) strongly enhanced antigen presentation
Externí odkaz:
https://doaj.org/article/116d0102ba984134b3b45409c8b1b84b
Autor:
Johannes Gregor Matthias Rack, Qiang Liu, Valentina Zorzini, Jim Voorneveld, Antonio Ariza, Kourosh Honarmand Ebrahimi, Julia M. Reber, Sarah C. Krassnig, Dragana Ahel, Gijsbert A. van der Marel, Aswin Mangerich, James S. O. McCullagh, Dmitri V. Filippov, Ivan Ahel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
PARG and ARH3 are the main hydrolases to reverse serine poly(ADP-ribosylation) yet their activities in the process differ. Here, the authors synthesise linear and branched poly(ADP-ribose) molecules, perform structure-function analysis and elucidate
Externí odkaz:
https://doaj.org/article/4bbd22b00672441db09292221ae3ea22
Autor:
Jacopo Enotarpi, Marta Tontini, Cristiana Balocchi, Daan van der Es, Ludovic Auberger, Evita Balducci, Filippo Carboni, Daniela Proietti, Daniele Casini, Dmitri V. Filippov, Hermen S. Overkleeft, Gijsbert A. van der Marel, Cinzia Colombo, Maria Rosaria Romano, Francesco Berti, Paolo Costantino, Jeroen D. C. Codeé, Luigi Lay, Roberto Adamo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
The Neisseria meningitidis serogroup A capsular polysaccharide (MenA CPS) is a component of commercial vaccines, but is unstable. Here, the authors generate glycomimetic oligomers that demonstrate higher stability than their natural counterparts and
Externí odkaz:
https://doaj.org/article/1d2c58955e994faaa3143dcfc9de2b58
Autor:
Thomas Hansen, Hidde Elferink, Jacob M. A. van Hengst, Kas J. Houthuijs, Wouter A. Remmerswaal, Alexandra Kromm, Giel Berden, Stefan van der Vorm, Anouk M. Rijs, Hermen S. Overkleeft, Dmitri V. Filippov, Floris P. J. T. Rutjes, Gijsbert A. van der Marel, Jonathan Martens, Jos Oomens, Jeroen D. C. Codée, Thomas J. Boltje
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Dioxolenium ion intermediates formed from remote positions are hypothesized to direct stereoselective glycosylations. Herein we combine infrared ion spectroscopy, DFT calculations and synthetic work to characterize and study these dioxolenium ions an
Externí odkaz:
https://doaj.org/article/6ec49b5d3eff4a6ea8a8b5a70ecb1904
Autor:
Thomas Hansen, Ludivine Lebedel, Wouter A. Remmerswaal, Stefan van der Vorm, Dennis P. A. Wander, Mark Somers, Herman S. Overkleeft, Dmitri V. Filippov, Jérôme Désiré, Agnès Mingot, Yves Bleriot, Gijsbert A. van der Marel, Sebastien Thibaudeau, Jeroen D. C. Codée
Publikováno v:
ACS Central Science, Vol 5, Iss 5, Pp 781-788 (2019)
Externí odkaz:
https://doaj.org/article/5fe9ceb3d2224603acb1f3753c3e07c3
Autor:
Gijs G. Zom, Marian M. J. H. P. Willems, Selina Khan, Tetje C. van der Sluis, Jan Willem Kleinovink, Marcel G. M. Camps, Gijsbert A. van der Marel, Dmitri V. Filippov, Cornelis J. M. Melief, Ferry Ossendorp
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-13 (2018)
Abstract Background Ligands for the Toll-like receptor (TLR) family can induce activation of cells of the innate immune system and are widely studied for their potential to enhance adaptive immunity. Conjugation of TLR2-ligand Pam3CSK4 to synthetic l
Externí odkaz:
https://doaj.org/article/709a690ddcf245d583864fadeb597229
Autor:
Rui-Jun Eveline Li, Tim P. Hogervorst, Silvia Achilli, Sven C. M. Bruijns, Sander Spiekstra, Corinne Vivès, Michel Thépaut, Dmitri V. Filippov, Gijs A. van der Marel, Sandra J. van Vliet, Franck Fieschi, Jeroen D. C. Codée, Yvette van Kooyk
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Langerhans cells (LCs) are antigen-presenting cells that reside in the skin. They uniquely express high levels of the C-type lectin receptor Langerin (CD207), which is an attractive target for antigen delivery in immunotherapeutic vaccination strateg
Externí odkaz:
https://doaj.org/article/85f1597e8e6748afb698b1efd024ac0c