Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Dmitri Madera"'
Autor:
J. Silvio Gutkind, Robert L. Ferris, Raja R. Seethala, William N. William, Heather M. Walline, Christine M. Komarck, Jonathan B. McHugh, Thomas E. Carey, Nitin Gangane, Alfredo A. Molinolo, Abraham Schneider, Daniel Martin, Lynn Vitale-Cross, Dmitri Madera
Most squamous cell carcinomas of the head and neck (HNSCC) exhibit a persistent activation of the PI3K–mTOR signaling pathway. We have recently shown that metformin, an oral antidiabetic drug that is also used to treat lipodystrophy in HIV-infected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ebe021b3cd9c699280070cab44d3ccd
https://doi.org/10.1158/1940-6207.c.6544914.v1
https://doi.org/10.1158/1940-6207.c.6544914.v1
Autor:
J. Silvio Gutkind, Robert L. Ferris, Raja R. Seethala, William N. William, Heather M. Walline, Christine M. Komarck, Jonathan B. McHugh, Thomas E. Carey, Nitin Gangane, Alfredo A. Molinolo, Abraham Schneider, Daniel Martin, Lynn Vitale-Cross, Dmitri Madera
Figure S1. HNSCC cell lines CAL27, CAL33 and UMSCC47 were treated with the indicated concentrations of metformin or with rapamycin for colony formation assay (see Materials and Methods).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21091a8fa52e6240357de5fef533ec43
https://doi.org/10.1158/1940-6207.22525809.v1
https://doi.org/10.1158/1940-6207.22525809.v1
Autor:
Thomas E. Carey, Nitin Gangane, Christine M. Komarck, Heather M. Walline, Daniel Martin, Dmitri Madera, Alfredo A. Molinolo, William N. William, Raja R. Seethala, Lynn Vitale-Cross, Jonathan B. McHugh, J. Silvio Gutkind, Abraham Schneider, Robert L. Ferris
Publikováno v:
Cancer Prevention Research. 8:197-207
Most squamous cell carcinomas of the head and neck (HNSCC) exhibit a persistent activation of the PI3K–mTOR signaling pathway. We have recently shown that metformin, an oral antidiabetic drug that is also used to treat lipodystrophy in HIV-infected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763706de62b5554b5d2405b24903919f
https://doi.org/10.1158/1940-6207.capr-14-0348
https://doi.org/10.1158/1940-6207.capr-14-0348
Autor:
Lihua Julie Zhu, John Anto Pulikkan, Peter J. M. Valk, Dmitri Madera, Ya-Huei Kuo, Lucio H. Castilla, Saman Abbas, Paul Bradley, Liting Xue, Sean Landrette
Publikováno v:
Blood, 120(4), 868-879. American Society of Hematology
Oncogenic mutations in components of cytokine signaling pathways elicit ligand-independent activation of downstream signaling, enhancing proliferation and survival in acute myeloid leukemia (AML). The myeloproliferative leukemia virus oncogene, MPL,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22723daa2d4dfea7a13c5ae4ddc01749
https://doi.org/10.1182/blood-2012-03-414649
https://doi.org/10.1182/blood-2012-03-414649
Publikováno v:
Leukemia
Cytokine signaling pathways are frequent targets of oncogenic mutations in acute myeloid leukemia, promoting proliferation and survival. We have previously shown that the transcription factor PLAGL2 promotes proliferation and cooperates with the leuk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a599c4e374ff08ecd5e42400019aab
https://doi.org/10.1038/leu.2010.301
https://doi.org/10.1038/leu.2010.301
Publikováno v:
FEBS Letters. 557:185-192
Presenilins (PS1 and PS2) are supposed to be unusual aspartic proteases and components of the γ-secretase complex regulating cleavage of type I proteins. Multiple mutations in PS1 are a major cause of familial early-onset Alzheimer’s disease (AD).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0a630b09a64ba47d39578d749819cb
https://doi.org/10.1016/s0014-5793(03)01489-3
https://doi.org/10.1016/s0014-5793(03)01489-3