Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Dmitri Gourevitch"'
Autor:
Kamila Bedelbaeva, Benjamin Cameron, John Latella, Azamat Aslanukov, Dmitri Gourevitch, Ramana Davuluri, Ellen Heber-Katz
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: The MRL mouse strain is one of the few examples of a mammal capable of healing appendage wounds by regeneration, a process that begins with the formation of a blastema, a structure containing de-differentiating mesenchymal cells. HIF-1
Externí odkaz:
https://doaj.org/article/bc2739f7507b481d85bb4d343953e449
Autor:
Kamila Bedelbaeva, Young Zhang, Azamat Azlanukov, Dmitri Gourevitch, Iossif Strehin, Phillip Messersmith, Ellen Heber-Katz
The long-noted observation that endostatin is a potent inhibitor of tumor vasculature but has little or no effect on wound repair or pregnancy remains an “as of yet unexplained but remarkable phenomenon”(1). However, there is another path to woun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b808303b6f2e810ff91d28a49267443
https://doi.org/10.1101/2022.03.02.482660
https://doi.org/10.1101/2022.03.02.482660
Publikováno v:
Gene Therapy and Regulation. :51-70
In this review, we discuss recent studies relating to major features of adult MRL mouse biology that contribute to the regenerative responses seen. These include an increased inflammatory cell profile, a unique glycolytic metabolic state typically fo
Autor:
Kamila Bedelbaeva, Renee M. Demarest, Anthony J. Capobianco, Andrew Snyder, Lise Clark, L. Matthew Arthur, Paul M. Lieberman, Lionel Feigenbaum, Rhonda Anderson, Ellen Heber-Katz, Dmitri Gourevitch
Publikováno v:
Cell Cycle. 9:3691-3697
The process of regeneration is most readily studied in species of sponge, hydra, planarian and salamander (i.e., newt and axolotl). The closure of MRL mouse ear pinna through-and-through holes provides a mammalian model of unusual wound healing/regen
Autor:
Lise Clark, Andrew Snyder, Dmitri Gourevitch, Ellen Heber-Katz, Xiang-Ming Zhang, Khamilia Bedelbaeva, John Leferovich, Paul M. Lieberman, James M. Cheverud
Publikováno v:
Proceedings of the National Academy of Sciences. 107:5845-5850
Animals capable of regenerating multiple tissue types, organs, and appendages after injury are common yet sporadic and include some sponge, hydra, planarian, and salamander (i.e., newt and axolotl) species, but notably such regenerative capacity is r
Autor:
Dmitri Gourevitch, Ellen Heber-Katz
Publikováno v:
Annals of the New York Academy of Sciences. 1172:110-114
The matrix metalloproteinases (MMPs) have been implicated in the regenerative response in amphibians and various mammalian models of regeneration. The neutrophil response is known to bring MMPs and other proteases to the wound to promote bacterial el
Autor:
Phillip B. Messersmith, Lise Clark, Khamilia Bedelbaeva, John Leferovich, Iossif Strehin, Dmitri Gourevitch, Yong Zhang, Ellen Heber-Katz
Publikováno v:
Science translational medicine. 7(290)
Whereas amphibians regenerate lost appendages spontaneously, mammals generally form scars over the injury site through the process of wound repair. The MRL mouse strain is an exception among mammals because it shows a spontaneous regenerative healing
Autor:
Stefan J. Samulewicz, Natasha Levenkova, Ellen Heber-Katz, Xiang-Ming Zhang, John J. Rux, Alexander Seitz, Dmitri Gourevitch, Lise Clark, Maja Kragol, Pan Chen
Publikováno v:
Human Molecular Genetics. 14:2661-2670
The apolipoprotein E (ApoE) gene has been linked to maladies such as hypercholesterolemia, CNS injury and disease. In this study, we present evidence that, in addition to the known transcript (ApoE S1) that translates into ApoE, there are three addit
Autor:
Dmitri Gourevitch, Ellen Heber-Katz, John Leferovich, Khamilia Bedelbaeva, Lise Clark, Pan Chen
Publikováno v:
Cloning and Stem Cells. 6:352-363
We previously demonstrated that after a severe cryoinjury to the right ventricle of the heart, adult MRL mice display structural and functional recovery with myocardial tissue replacement resembling that seen in amphibians. The control non-regenerati
Publikováno v:
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 359:785-793
The ability to regenerate tissues and limbs in its most robust form is seen in many non–mammalian species. The serendipitous discovery that the MRL mouse has a profound capacity for regeneration in some ways rivalling the classic newt and axolotl s