Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Dmitri A. Ivanov"'
Autor:
Dmitri A. Ivanov
Publikováno v:
SciPost Physics Core, Vol 7, Iss 2, p 022 (2024)
It is known that computing the permanent of the matrix 1+A, where A is a finite-rank matrix, requires a number of operations polynomial in the matrix size. Motivated by the boson-sampling proposal of restricted quantum computation, I extend this resu
Externí odkaz:
https://doaj.org/article/b9c9092ab9684f61a129e1ca8a4fd9a1
Autor:
Angel Bulnes-Ramos, Kerstin Schott, Jesse Rabinowitz, Charlotte Luchsinger, Cinzia Bertelli, Eri Miyagi, Corey H. Yu, Mirjana Persaud, Caitlin Shepard, Renate König, Baek Kim, Dmitri N. Ivanov, Klaus Strebel, Felipe Diaz-Griffero
Publikováno v:
mBio, Vol 15, Iss 9 (2024)
ABSTRACT In humans, sterile alpha motif (SAM) domain- and histidine–aspartic acid (HD) domain-containing protein 1 (SAMHD1) is a dNTPase enzyme that prevents HIV-1 infection in non-cycling cells, such as differentiated THP-1 cells and human primary
Externí odkaz:
https://doaj.org/article/c9f56ba73d444171b8aaf82bbd3b5756
Autor:
Corey H. Yu, Akash Bhattacharya, Mirjana Persaud, Alexander B. Taylor, Zhonghua Wang, Angel Bulnes-Ramos, Joella Xu, Anastasia Selyutina, Alicia Martinez-Lopez, Kristin Cano, Borries Demeler, Baek Kim, Stephen C. Hardies, Felipe Diaz-Griffero, Dmitri N. Ivanov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
SAMHD1 catalyses the dephosphorylation of deoxynucleotide triphosphates (dNTPs) and has antiretroviral activity. Here, the authors present the crystal structures of SAMHD1-oligonucleotide complexes, which reveal that the allosteric binding sites of S
Externí odkaz:
https://doaj.org/article/235030ae21f844b790931e36a84dca12
Autor:
Zinaida Yudina, Amanda Roa, Rory Johnson, Nikolaos Biris, Daniel A. de Souza Aranha Vieira, Vladislav Tsiperson, Natalia Reszka, Alexander B. Taylor, P. John Hart, Borries Demeler, Felipe Diaz-Griffero, Dmitri N. Ivanov
Publikováno v:
Cell Reports, Vol 12, Iss 5, Pp 788-797 (2015)
Members of the tripartite motif (TRIM) protein family of RING E3 ubiquitin (Ub) ligases promote innate immune responses by catalyzing synthesis of polyubiquitin chains linked through lysine 63 (K63). Here, we investigate the mechanism by which the TR
Externí odkaz:
https://doaj.org/article/7ab8e8877fc54cca9fe261f6a7241139
Autor:
Akash Bhattacharya, Corey H. Yu, Kristin E. Cano, Anastasia Selyutina, Angel Bulnes-Ramos, Baek Kim, Alicia Martinez-Lopez, Zhonghua Wang, Joella Xu, Stephen C. Hardies, Dmitri N. Ivanov, Mirjana Persaud, Alexander B. Taylor, Felipe Diaz-Griffero, Borries Demeler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
SAMHD1 impedes infection of myeloid cells and resting T lymphocytes by retroviruses, and the enzymatic activity of the protein—dephosphorylation of deoxynucleotide triphosphates (dNTPs)—implicates enzymatic dNTP depletion in innate antiviral immu
Autor:
Frank Herkules, Corey H. Yu, Alexander B. Taylor, Vi Dougherty, Susan T. Weintraub, Dmitri N. Ivanov
Publikováno v:
Nature communications. 13(1)
TRIM5α is an E3 ubiquitin ligase of the TRIM family that binds to the capsids of primate immunodeficiency viruses and blocks viral replication after cell entry. Here we investigate how synthesis of K63-linked polyubiquitin is upregulated by transien
Autor:
Yong Xiong, Fidel Arizaga, Adrian Oo, Nicole E. Bowen, Caitlin Shepard, Baek Kim, David S. Yu, Joshua Temple, Corey H. Yu, Dmitri N. Ivanov, Felipe Diaz-Griffero, Dong-Hyun Kim, Mirjana Persaud, Priya Kapoor-Vazirani, Raymond F. Schinazi
Publikováno v:
The Journal of Biological Chemistry
Elevated intracellular levels of dNTPs have been shown to be a biochemical marker of cancer cells. Recently, a series of mutations in the multifunctional dNTP triphosphohydrolase (dNTPase), sterile alpha motif and histidine–aspartate domain–conta
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138780 (2015)
The human antigen R (HuR) stabilizes many mRNAs of proto-oncogene, transcription factors, cytokines and growth factors by recognizing AU-rich elements (AREs) presented in their 3' or 5' untranslated region (UTR). Multiple lines of experimental eviden
Externí odkaz:
https://doaj.org/article/1e969db823e04982b0b509f794e85f87
Autor:
Johanna Villarreal, Mei Qiao, Greco Hernández, Caihong Yi, Dmitri N. Ivanov, Mitzli X. Velasco, Luiz O. F. Penalva, Zhonghua Wang, Matthew J. Hart, Yogesh K. Gupta, Christopher G. Hubert, Soni Kaundal, Guiming Li
Publikováno v:
RNA Biology. 15:1420-1432
RNA binding proteins have emerged as critical oncogenic factors and potential targets in cancer therapy. In this study, we evaluated Musashi1 (Msi1) targeting as a strategy to treat glioblastoma (GBM); the most aggressive brain tumor type. Msi1 expre
Autor:
Joshua Temple, Fidel Arizaga, Baek Kim, Mirjana Persaud, Dong-Hyun Kim, Caitlin Shepard, Yong Xiong, Adrian Oo, Felipe Diaz-Griffero, Nicole E. Bowen, Corey H. Yu, Priya Kapoor-Vazirani, Raymond F. Schinazi, Dmitri N. Ivanov, David S. Yu
Publikováno v:
SSRN Electronic Journal.
Elevated intracellular dNTP level is a biochemical marker of cancer cells. Recently, a series of mutations in a highly multi-functional dNTPase, SAMHD1, have been reported in various cancers. Here we investigated the role of SAMHD1 in cancer by chara