Zobrazeno 1 - 10
of 224
pro vyhledávání: '"Dmitri A Rusakov"'
Publikováno v:
eLife, Vol 10 (2021)
Glutamate uptake by astroglial transporters confines excitatory transmission to the synaptic cleft. The efficiency of this mechanism depends on the transporter dynamics in the astrocyte membrane, which remains poorly understood. Here, we visualise th
Externí odkaz:
https://doaj.org/article/d1962fc388a94469b4a954c88c06fb4a
Publikováno v:
eLife, Vol 10 (2021)
Dendritic integration of synaptic inputs involves their increased electrotonic attenuation at distal dendrites, which can be counterbalanced by the increased synaptic receptor density. However, during network activity, the influence of individual syn
Externí odkaz:
https://doaj.org/article/951598e8ad9d45d18bca07fb85042475
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 3, p e1005467 (2017)
Creating and running realistic models of neural networks has hitherto been a task for computing professionals rather than experimental neuroscientists. This is mainly because such networks usually engage substantial computational resources, the handl
Externí odkaz:
https://doaj.org/article/cc298f6b2ef34bd4bf6554190088b299
Autor:
Yaroslav S Ermolyuk, Felicity G Alder, Christian Henneberger, Dmitri A Rusakov, Dimitri M Kullmann, Kirill E Volynski
Publikováno v:
PLoS Biology, Vol 10, Iss 9, p e1001396 (2012)
The efficacy of action potential evoked neurotransmitter release varies widely even among synapses supplied by the same axon, and the number of release-ready vesicles at each synapse is a major determinant of this heterogeneity. Here we identify a se
Externí odkaz:
https://doaj.org/article/e70fe9f217254b308ad98e93e29615e0
Autor:
Olga Kopach, Sergyi Sylantyev, Lucie Bard, Piotr Michaluk, Janosch P. Heller, Ana Gutierrez del Arroyo, Gareth L. Ackland, Alexander V. Gourine, Dmitri A. Rusakov
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107236- (2023)
Summary: Neutrophils are white blood cells that are critical to acute inflammatory and adaptive immune responses. Their swarming-pattern behavior is controlled by multiple cellular cascades involving calcium-dependent release of various signaling mol
Externí odkaz:
https://doaj.org/article/e29399bbfa284d4aac50d5a7106fd7e9
Publikováno v:
Cells, Vol 12, Iss 12, p 1610 (2023)
Once outside the synaptic cleft, the excitatory neurotransmitter glutamate is rapidly bound by its high-affinity transporters, which are expressed in abundance on the surface of perisynaptic astroglia. While this binding and the subsequent uptake of
Externí odkaz:
https://doaj.org/article/f782db8686824534ab06180e7489f474
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-5 (2020)
In the original publication of this article [1], text has been introduced erroneously to Figs. 4a and 5d due to a typesetting mistake.
Externí odkaz:
https://doaj.org/article/118db9d641724502b7aea61b843c0be1
Autor:
Olga A. Sindeeva, Olga Kopach, Maxim A. Kurochkin, Andrei Sapelkin, David J. Gould, Dmitri A. Rusakov, Gleb B. Sukhorukov
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
The patterned microchamber arrays based on biocompatible polymers are a versatile cargo delivery system for drug storage and site-/time-specific drug release on demand. However, functional evidence of their action on nerve cells, in particular their
Externí odkaz:
https://doaj.org/article/f685e079812c43d8a6c012ab5e0c7f4c
Autor:
Claire M. King, Kirsten Bohmbach, Daniel Minge, Andrea Delekate, Kaiyu Zheng, James Reynolds, Cordula Rakers, Andre Zeug, Gabor C. Petzold, Dmitri A. Rusakov, Christian Henneberger
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3466-3477.e4 (2020)
Summary: Astroglia regulate neurovascular coupling while engaging in signal exchange with neurons. The underlying cellular machinery is thought to rely on astrocytic Ca2+ signals, but what controls their amplitude and waveform is poorly understood. H
Externí odkaz:
https://doaj.org/article/0f3f6c9922ef4b15bbd5904377a6ec43
Autor:
Olga Kopach, Kayiu Zheng, Luo Dong, Andrei Sapelkin, Nana Voitenko, Gleb B. Sukhorukov, Dmitri A. Rusakov
Publikováno v:
Drug Delivery, Vol 25, Iss 1, Pp 435-447 (2018)
Persistent pain remains a major health issue: common treatments relying on either repeated local injections or systemic drug administration are prone to concomitant side-effects. It is thought that an alternative could be a multifunctional cargo syst
Externí odkaz:
https://doaj.org/article/3472fd2454674001bda63f95f7948106