Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Dmitri, Rebatchouk"'
Autor:
Xiaohong Zhao, Tint Lwin, Ariosto Silva, Bijal Shah, Jiangchuan Tao, Bin Fang, Liang Zhang, Kai Fu, Chengfeng Bi, Jiannong Li, Huijuan Jiang, Mark B. Meads, Timothy Jacobson, Maria Silva, Allison Distler, Lancia Darville, Ling Zhang, Ying Han, Dmitri Rebatchouk, Maurizio Di Liberto, Lynn C. Moscinski, John M. Koomen, William S. Dalton, Kenneth H. Shain, Michael Wang, Eduardo Sotomayor, Jianguo Tao
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Ibrutinib has demonstrated high response rates in B-cell lymphomas but a lot of ibrutinib-treated patients relapse with resistance. This study unified TME-mediatedde novoand acquired drug resistance through B-cell receptor signalling and PI3K-AKT-mTO
Externí odkaz:
https://doaj.org/article/87b74c23a81c4b28a5b297ad5bef630b
Autor:
Kenneth H. Shain, Mark B. Meads, Eduardo Sontag, Robert Gillies, Robert Gatenby, James Greene, William Dalton, Dmitri Rebatchouk, Lia Perez, Rachid Baz, Christopher Cubitt, Lu Chen, Dung-Tsa Chen, Jinming Song, Tuan Nguyen, Aunshka Collins, Timothy Jacobson, Allison Distler, Praneeth Sudalagunta, Maria C. Silva, Ariosto Silva
Supplemental Figures and Tables to augment (1) the mathematical modeling (providing details on specific therapeutics); (2) patient characteristics (treatment history, clinical and predicted response), (3) synergistic activities identified by EMMA; an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e40fa9a12e6f34c664a5aab099ac88
https://doi.org/10.1158/0008-5472.22413492
https://doi.org/10.1158/0008-5472.22413492
Autor:
Kenneth H. Shain, Mark B. Meads, Eduardo Sontag, Robert Gillies, Robert Gatenby, James Greene, William Dalton, Dmitri Rebatchouk, Lia Perez, Rachid Baz, Christopher Cubitt, Lu Chen, Dung-Tsa Chen, Jinming Song, Tuan Nguyen, Aunshka Collins, Timothy Jacobson, Allison Distler, Praneeth Sudalagunta, Maria C. Silva, Ariosto Silva
Multiple myeloma remains treatable but incurable. Despite a growing armamentarium of effective agents, choice of therapy, especially in relapse, still relies almost exclusively on clinical acumen. We have developed a system, Ex vivo Mathematical Myel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4c8ea1e40acfd2191f194915500445e
https://doi.org/10.1158/0008-5472.c.6508731.v1
https://doi.org/10.1158/0008-5472.c.6508731.v1
Autor:
Kenneth H. Shain, Mark B. Meads, Eduardo Sontag, Robert Gillies, Robert Gatenby, James Greene, William Dalton, Dmitri Rebatchouk, Lia Perez, Rachid Baz, Christopher Cubitt, Lu Chen, Dung-Tsa Chen, Jinming Song, Tuan Nguyen, Aunshka Collins, Timothy Jacobson, Allison Distler, Praneeth Sudalagunta, Maria C. Silva, Ariosto Silva
Individual patient EMMA predicitons of actual responses to therapy (companion to Figure 3i).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74fac539d7d2cfa939c1a8e55b9c83c3
https://doi.org/10.1158/0008-5472.22413495
https://doi.org/10.1158/0008-5472.22413495
Autor:
Peter O. Fedichev, Ashok Nuthanakanti, Evgeny Nudler, Alexander Mironov, Dmitry Shishov, Ilya Shamovsky, Mirna Lechpammer, Nikita Vasilyev, Elena Shatalina, Konstantin Shatalin, Dmitri Rebatchouk, Abhishek Kaushik, Alla Peselis, Bibhusita Pani, Alexander Serganov
Publikováno v:
Science. 372:1169-1175
Turning down tolerance Persister cells, which are found in abundance in biofilms, adopt a quiescent state and survive antimicrobial treatments, seeding disease recurrence and incubating new resistance mutations. Building on work implicating the react
Autor:
Konstantin, Shatalin, Ashok, Nuthanakanti, Abhishek, Kaushik, Dmitry, Shishov, Alla, Peselis, Ilya, Shamovsky, Bibhusita, Pani, Mirna, Lechpammer, Nikita, Vasilyev, Elena, Shatalina, Dmitri, Rebatchouk, Alexander, Mironov, Peter, Fedichev, Alexander, Serganov, Evgeny, Nudler
Publikováno v:
Science (New York, N.Y.). 372(6547)
Emergent resistance to all clinical antibiotics calls for the next generation of therapeutics. Here we report an effective antimicrobial strategy targeting the bacterial hydrogen sulfide (H
Autor:
Maria Daniela Silva, Robert A. Gatenby, Kenneth H. Shain, Eduardo D. Sontag, Lia Perez, Robert J. Gillies, Dung-Tsa Chen, Timothy Jacobson, Mark B. Meads, Praneeth Reddy Sudalagunta, Lu Chen, Allison Distler, Aunshka Collins, Tuan Nguyen, Christopher L. Cubitt, Jinming Song, James M. Greene, Ariosto S. Silva, William S. Dalton, Dmitri Rebatchouk, Rachid Baz
Publikováno v:
Cancer Research. 77:3336-3351
Multiple myeloma remains treatable but incurable. Despite a growing armamentarium of effective agents, choice of therapy, especially in relapse, still relies almost exclusively on clinical acumen. We have developed a system, Ex vivo Mathematical Myel
Autor:
Eduardo M. Sotomayor, Bijal D. Shah, J Tao, Kenneth H. Shain, Tint Lwin, Ying Han, Kai Fu, Lynn C. Moscinski, Huijuan Jiang, Ling Zhang, John M. Koomen, Allison Distler, Xiaohong Zhao, William S. Dalton, Dmitri Rebatchouk, Liang Zhang, Bin Fang, Timothy Jacobson, Chengfeng Bi, Mark B. Meads, Lancia Darville, Jiannong Li, Jianguo Tao, M. E. R. Silva, Michael Wang, Ariosto S. Silva, Maurizio Di Liberto
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
The novel Bruton's tyrosine kinase inhibitor ibrutinib has demonstrated high response rates in B-cell lymphomas; however, a growing number of ibrutinib-treated patients relapse with resistance and fulminant progression. Using chemical proteomics and
Autor:
Ariosto, Silva, Maria C, Silva, Praneeth, Sudalagunta, Allison, Distler, Timothy, Jacobson, Aunshka, Collins, Tuan, Nguyen, Jinming, Song, Dung-Tsa, Chen, Lu, Chen, Christopher, Cubitt, Rachid, Baz, Lia, Perez, Dmitri, Rebatchouk, William, Dalton, James, Greene, Robert, Gatenby, Robert, Gillies, Eduardo, Sontag, Mark B, Meads, Kenneth H, Shain
Publikováno v:
Cancer Res
Multiple myeloma (MM) remains treatable but incurable. Despite a growing armamentarium of effective agents, choice of therapy, especially in relapse, still relies almost exclusively on clinical acumen. We have developed a system, EMMA (Ex vivo Mathem
Autor:
Chris Cubitt, Kenneth H. Shain, Lia Perez, Allison Distler, Ariosto S. Silva, Maria D.M.C. Ribeiro da Silva, Timothy Jacobson, Aunshka Collins, Mark B. Meads, Robert A. Gatenby, Rachid Baz, Dmitri Rebatchouk
Publikováno v:
Blood. 128:3291-3291
Introduction: Multiple myeloma is a heterogeneous plasma cell neoplasm that remains all but incurable despite significant advances in treatment. We anticipate that the ability to overcome this hurdle resides in personalized strategies designed to spe