Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function

Autor: Hagenaars, Sp, Radaković, R, Crockford, C, Fawns-Ritchie, C, Gale, Cr, Deary, Ij, J B, J Kwok, Dobson-Stone, C, R Schofield, P, Gmhalliday, R Hodges, J, Piguet, O, Bartley, L, Thompson, E, Hernaândez, I, Ruiz, A, Mboada, Borroni, B, Padovani, A, Cruchaga, C, J Cairns, N, Benussi, L, Binetti, G, Ghidoni, R, Forloni, G, Albani, D, Galimberti, D, Fenoglio, C, Serpente, M, Scarpini, E, Clarimoân, J, Lleoâ, A, Blesa, R, Mlandqvist, Waldoè, Nilsson, K, Nilsson, C, I R, A Mackenzie, G-Y, R Hsiung, Dma, Mann, Grafman, J, Cmmorris, Attems, J, D Griffiths, T, G McKeith, I, J Thomas, A, Pietrini, P, D Huey, E, Emwassermann, Baborie, A, Jaros, E, Tierney, Mc, Pastor, P, Razquin, C, Ortega-Cubero, S, Alonso, E, Perneczky, R, Diehl-Schmid, J, Alexopoulos, P, Kurz, A, Rainero, I, Rubino, E, Pinessi, L, Rogaeva, E, P St George-Hyslop, Rossi, G, Tagliavini, F, Giaccone, G, B Rowe, J, Cmschlachetzki, J, Uphill, J, Collinge, J, Mead, S, Danek, A, Vmvan, Deerlin, Mgrossman, Q Trojanowski, J, J van der Zee, C Van Broeckhoven, F Cappa, S, Leber, I, Hannequin, D, Golfier, V, Mvercelletto, Brice, A, Nacmias, B, Sorbi, S, Bagnoli, S, Piaceri, I, E Nielsen, J, E Hjermind, L, Mriemenschneider, Mmayhaus, Ibach, B, Gasparoni, G, Pichler, S, Wgu, Rossor, Mn, C Fox, N, D Warren, J, Spillantini, Mg, R Morris, H, Rizzu, P, Heutink, P, S Snowden, J, Rollinson, S, Richardson, A, Gerhard, A, C Bruni, A, Maletta, R, Frangipane, F, Cupidi, C, Bernardi, L, Manfossi, Mgallo, Conidi, Me, Smirne, N, Rademakers, R, Baker, M, Dwdickson, R Graff-Radford, N, C Petersen, R, Knopman, D, A Josephs, K, F Boeve, B, E Parisi, J, Wwseeley, L Miller, B, Amkarydas, Rosen, H, C van Swieten, J, E G, P Dopper, Seelaar, H, Y A, L Pijnenburg, Scheltens, P, Logroscino, G, Capozzo, R, Novelli, V, A Puca, A, Franceschi, M, Postiglione, A, Milan, G, Sorrentino, P, Mkristiansen, H-H, Chiang, Graff, C, Pasquier, F, Rollin, A, Deramecourt, V, Lebouvier, T, Kapogiannis, D, Ferrucci, L, Pickering-Brown, S, B Singleton, A, Hardy, J, Momeni., P

Publikováno v: PLoS ONE

INTRODUCTIONIt is unclear whether polygenic risk for neurodegenerative disease is associated with cognitive performance and physical health.METHODSThis study tested whether polygenic scores for Alzheimer’s disease (AD), Amyotrophic Lateral Sclerosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9324af677ad2f742c6db0353d52a42
https://ueaeprints.uea.ac.uk/id/eprint/67429/

Apraxia phenotypes and frontotemporal lobar degeneration.

Autor: Langheinrich TC; Cerebral Function Unit, Manchester Centre for Clinical Neurosciences, Northern Care AllianceNHS Foundation Trust, Salford, UK. tobias.langheinrich@nca.nhs.uk.; Division of Psychology, Communication & Human Neuroscience, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. tobias.langheinrich@nca.nhs.uk., Thompson JC; Cerebral Function Unit, Manchester Centre for Clinical Neurosciences, Northern Care AllianceNHS Foundation Trust, Salford, UK.; Division of Psychology, Communication & Human Neuroscience, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Jones M; Cerebral Function Unit, Manchester Centre for Clinical Neurosciences, Northern Care AllianceNHS Foundation Trust, Salford, UK.; Division of Medical Education, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Richardson AMT; Cerebral Function Unit, Manchester Centre for Clinical Neurosciences, Northern Care AllianceNHS Foundation Trust, Salford, UK.; Division of Medical Education, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Mann DMA; Division of Neuroscience, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Snowden JS; Cerebral Function Unit, Manchester Centre for Clinical Neurosciences, Northern Care AllianceNHS Foundation Trust, Salford, UK.; Division of Neuroscience, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Publikováno v: Journal of neurology [J Neurol] 2024 Dec; Vol. 271 (12), pp. 7471-7488. Date of Electronic Publication: 2024 Oct 10.

Self-Reported Late-Life Hypertension Is Associated with a Healthy Cognitive Status and Reduced Alzheimer's Disease Pathology Burden.

Autor: Robinson AC; Faculty of Biology, Medicine and Health, School of Biological Sciences, Division of Neuroscience, The University of Manchester, Salford Royal Hospital, Salford, UK.; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre (MAHSC), Manchester, UK., Bin Rizwan T; Faculty of Biology, Medicine and Health, School of Medical Sciences, School of Health Sciences, The University of Manchester, Manchester, UK., Davidson YS; Faculty of Biology, Medicine and Health, School of Biological Sciences, Division of Neuroscience, The University of Manchester, Salford Royal Hospital, Salford, UK., Minshull J; Faculty of Biology, Medicine and Health, School of Biological Sciences, Division of Neuroscience, The University of Manchester, Salford Royal Hospital, Salford, UK., Tinkler P; Faculty of Biology, Medicine and Health, School of Biological Sciences, Division of Neuroscience, The University of Manchester, Salford Royal Hospital, Salford, UK., Payton A; Faculty of Biology, Medicine and Health, School of Health Sciences, Division of Informatics, Imaging and Data Sciences, The University of Manchester, Manchester, UK., Mann DMA; Faculty of Biology, Medicine and Health, School of Biological Sciences, Division of Neuroscience, The University of Manchester, Salford Royal Hospital, Salford, UK., Roncaroli F; Faculty of Biology, Medicine and Health, School of Biological Sciences, Division of Neuroscience, The University of Manchester, Salford Royal Hospital, Salford, UK.; Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre (MAHSC), Manchester, UK.

Publikováno v: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2024; Vol. 98 (4), pp. 1457-1466.

Cryo-EM structures of tau filaments from SH-SY5Y cells seeded with brain extracts from cases of Alzheimer's disease and corticobasal degeneration.

Autor: Tarutani A; Department of Brain & Neuroscience, Tokyo Metropolitan Institute of Medical Science, Japan.; Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan., Lövestam S; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK., Zhang X; Thermo Fisher Scientific, Eindhoven, The Netherlands., Kotecha A; Thermo Fisher Scientific, Eindhoven, The Netherlands., Robinson AC; School of Biological Sciences, University of Manchester, Salford, UK., Mann DMA; School of Biological Sciences, University of Manchester, Salford, UK., Saito Y; Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Japan., Murayama S; Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Japan.; Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders, United Graduate School of Child Development, Osaka University, Japan., Tomita T; Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan., Goedert M; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK., Scheres SHW; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK., Hasegawa M; Department of Brain & Neuroscience, Tokyo Metropolitan Institute of Medical Science, Japan.

Publikováno v: FEBS open bio [FEBS Open Bio] 2023 Aug; Vol. 13 (8), pp. 1394-1404. Date of Electronic Publication: 2023 Jul 07.

Erratum: Evaluation of ¹⁸ F-IAM6067 as a sigma-1 receptor PET tracer for neurodegeneration in vivo in rodents and in human tissue: Erratum.

Autor: Lepelletier FX; Faculty of Biology, Medicine and Health, School of Biological Sciences, Division of Neuroscience and Experimental Psychology, University of Manchester, Manchester, United Kingdom.; Wolfson Molecular Imaging Centre, University of Manchester, Manchester, United Kingdom., Vandesquille M; Faculty of Biology, Medicine and Health, School of Biological Sciences, Division of Neuroscience and Experimental Psychology, University of Manchester, Manchester, United Kingdom.; Wolfson Molecular Imaging Centre, University of Manchester, Manchester, United Kingdom., Asselin MC; Wolfson Molecular Imaging Centre, University of Manchester, Manchester, United Kingdom.; Faculty of Biology, Medicine and Health, School of Health Sciences, Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, United Kingdom., Prenant C; Wolfson Molecular Imaging Centre, University of Manchester, Manchester, United Kingdom., Robinson AC; Salford Royal NHS Foundation Trust, Department of Clinical & Cognitive Neurosciences, Clinical Sciences Building, Salford, United Kingdom., Mann DMA; Salford Royal NHS Foundation Trust, Department of Clinical & Cognitive Neurosciences, Clinical Sciences Building, Salford, United Kingdom., Green M; Wolfson Molecular Imaging Centre, University of Manchester, Manchester, United Kingdom.; Faculty of Biology, Medicine and Health, School of Health Sciences, Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, United Kingdom., Barnett E; Wolfson Molecular Imaging Centre, University of Manchester, Manchester, United Kingdom.; Faculty of Biology, Medicine and Health, School of Health Sciences, Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, United Kingdom., Banister SD; School of Chemistry, The University of Sydney, Sydney, Australia., Mottinelli M; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA., Mesangeau C; Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA., McCurdy CR; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.; UF Translational Drug Development Core, University of Florida, Gainesville, FL 32610, USA., Fricke IB; European Institute for Molecular Imaging (EIMI), Westfälische Wilhelms-Universität (WWU), Münster, Germany., Jacobs AH; European Institute for Molecular Imaging (EIMI), Westfälische Wilhelms-Universität (WWU), Münster, Germany.; Department of Geriatrics and Neurology, Johanniter Hospital, Bonn, Germany., Kassiou M; School of Chemistry, The University of Sydney, Sydney, Australia., Boutin H; Faculty of Biology, Medicine and Health, School of Biological Sciences, Division of Neuroscience and Experimental Psychology, University of Manchester, Manchester, United Kingdom.; Wolfson Molecular Imaging Centre, University of Manchester, Manchester, United Kingdom.

Publikováno v: Theranostics [Theranostics] 2022 Jul 08; Vol. 12 (12), pp. 5335-5336. Date of Electronic Publication: 2022 Jul 08 (Print Publication: 2022).