A DNA-PK phosphorylation site on MET regulates its signaling interface with the DNA damage response.

Autor: Koch JP; Department for BioMedical Research, Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.; Department of Radiation Oncology, Inselspital, Bern University Hospital, Freiburgstrasse 8, 3008, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, 3010, Bern, Switzerland., Roth SM; Department for BioMedical Research, Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.; Department of Radiation Oncology, Inselspital, Bern University Hospital, Freiburgstrasse 8, 3008, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, 3010, Bern, Switzerland., Quintin A; Department for BioMedical Research, Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.; Department of Radiation Oncology, Inselspital, Bern University Hospital, Freiburgstrasse 8, 3008, Bern, Switzerland., Gavini J; Graduate School for Cellular and Biomedical Sciences, University of Bern, 3010, Bern, Switzerland.; Department for BioMedical Research, Visceral Surgery, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland., Orlando E; Department for BioMedical Research, Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.; Department of Radiation Oncology, Inselspital, Bern University Hospital, Freiburgstrasse 8, 3008, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, 3010, Bern, Switzerland., Riedo R; Department for BioMedical Research, Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.; Department of Radiation Oncology, Inselspital, Bern University Hospital, Freiburgstrasse 8, 3008, Bern, Switzerland., Pozzato C; Department for BioMedical Research, Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.; Department of Radiation Oncology, Inselspital, Bern University Hospital, Freiburgstrasse 8, 3008, Bern, Switzerland., Hayrapetyan L; Department for BioMedical Research, Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.; Department of Radiation Oncology, Inselspital, Bern University Hospital, Freiburgstrasse 8, 3008, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, 3010, Bern, Switzerland., Aebersold R; Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, 8093, Zürich, Switzerland.; Faculty of Science, University of Zürich, 8057, Zürich, Switzerland., Stroka DM; Department for BioMedical Research, Visceral Surgery, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland., Aebersold DM; Department for BioMedical Research, Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.; Department of Radiation Oncology, Inselspital, Bern University Hospital, Freiburgstrasse 8, 3008, Bern, Switzerland., Medo M; Department for BioMedical Research, Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.; Department of Radiation Oncology, Inselspital, Bern University Hospital, Freiburgstrasse 8, 3008, Bern, Switzerland., Zimmer Y; Department for BioMedical Research, Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.; Department of Radiation Oncology, Inselspital, Bern University Hospital, Freiburgstrasse 8, 3008, Bern, Switzerland., Medová M; Department for BioMedical Research, Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland. michaela.medova@unibe.ch.; Department of Radiation Oncology, Inselspital, Bern University Hospital, Freiburgstrasse 8, 3008, Bern, Switzerland. michaela.medova@unibe.ch.

Publikováno v: Oncogene [Oncogene] 2023 Jun; Vol. 42 (26), pp. 2113-2125. Date of Electronic Publication: 2023 May 15.

CRIPTO promotes an aggressive tumour phenotype and resistance to treatment in hepatocellular carcinoma.

Autor: Karkampouna S; Department of Biomedical Research, Urology Group, University of Bern, Bern, Switzerland., van der Helm D; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Gray PC; Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, California, USA., Chen L; Institute of Biology, Department of Molecular Cell Biology, Leiden University, Leiden, The Netherlands., Klima I; Department of Biomedical Research, Urology Group, University of Bern, Bern, Switzerland., Grosjean J; Department of Biomedical Research, Urology Group, University of Bern, Bern, Switzerland., Burgmans MC; Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands., Farina-Sarasqueta A; Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands., Snaar-Jagalska EB; Institute of Biology, Department of Molecular Cell Biology, Leiden University, Leiden, The Netherlands., Stroka DM; Department of Biomedical Research, Visceral Surgery and Medicine, University of Bern, Bern University Hospital, Switzerland., Terracciano L; Molecular Pathology Division, Institute of Pathology, University Hospital Basel, Switzerland., van Hoek B; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Schaapherder AF; Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands., Osanto S; Department of Oncology, Leiden University Medical Center, Leiden, The Netherlands., Thalmann GN; Department of Biomedical Research, Urology Group, University of Bern, Bern, Switzerland.; Department of Urology, Bern University Hospital, Switzerland., Verspaget HW; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Coenraad MJ; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands., Kruithof-de Julio M; Department of Biomedical Research, Urology Group, University of Bern, Bern, Switzerland.; Department of Urology, Bern University Hospital, Switzerland.

Publikováno v: The Journal of pathology [J Pathol] 2018 Jul; Vol. 245 (3), pp. 297-310. Date of Electronic Publication: 2018 May 09.

Significant lethality following liver resection in A20 heterozygous knockout mice uncovers a key role for A20 in liver regeneration.

Autor: Studer P; Division of Vascular Surgery, Center for Vascular biology Research and the Transplant Institute, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Department of Visceral Surgery and Medicine, University Hospital Bern, Bern, Switzerland., da Silva CG; Division of Vascular Surgery, Center for Vascular biology Research and the Transplant Institute, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Revuelta Cervantes JM; Division of Vascular Surgery, Center for Vascular biology Research and the Transplant Institute, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Mele A; Division of Vascular Surgery, Center for Vascular biology Research and the Transplant Institute, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Csizmadia E; Division of Vascular Surgery, Center for Vascular biology Research and the Transplant Institute, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Siracuse JJ; Division of Vascular Surgery, Center for Vascular biology Research and the Transplant Institute, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Damrauer SM; Division of Vascular Surgery, Center for Vascular biology Research and the Transplant Institute, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Peterson CR; Division of Vascular Surgery, Center for Vascular biology Research and the Transplant Institute, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Candinas D; Department of Visceral Surgery and Medicine, University Hospital Bern, Bern, Switzerland., Stroka DM; Department of Visceral Surgery and Medicine, University Hospital Bern, Bern, Switzerland., Ma A; Division of Interdisciplinary Medicine and Biotechnology, Bioinformatics core, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Bhasin M; Division of Gastroenterology, Department of Medicine, University of California in San Francisco, San Fransisco, CA, USA., Ferran C; Division of Vascular Surgery, Center for Vascular biology Research and the Transplant Institute, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Publikováno v: Cell death and differentiation [Cell Death Differ] 2015 Dec; Vol. 22 (12), pp. 2068-77. Date of Electronic Publication: 2015 May 15.

Apoptosis in hypoxic human pancreatic islets correlates with HIF-1alpha expression.

Autor: Moritz W; Clinic for Visceral and Transplant Surgery, University Hospital Zürich, CH-8091 Zürich, Switzerland., Meier F, Stroka DM, Giuliani M, Kugelmeier P, Nett PC, Lehmann R, Candinas D, Gassmann M, Weber M

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2002 May; Vol. 16 (7), pp. 745-7. Date of Electronic Publication: 2002 Mar 26.

HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia.

Autor: Stroka DM; Liver Laboratories, University of Birmingham, Birmingham, UK. d.m.stroka@bham.ac.uk, Burkhardt T, Desbaillets I, Wenger RH, Neil DA, Bauer C, Gassmann M, Candinas D

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2001 Nov; Vol. 15 (13), pp. 2445-53.