Role of tumor necrosis factor alpha in hyperthermia-induced apoptosis of human leukemia cells

Autor: Dm, Katschinski, Hi, Robins, Schad M, Frede S, Joachim Fandrey

Publikováno v: Europe PubMed Central

We used the human myelomonoblastic leukemia cell line PLB-985 to study the effects of temperatures ranging from 37 degrees C to 43 degrees C for 1 h on the induction of apoptosis and cell cycle distribution in leukemia cells. The threshold temperatur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3d0e4b688e587aa1463b29f82ce3cc1b
http://europepmc.org/abstract/med/10416602

Elevated Na is a dynamic and reversible modulator of mitochondrial metabolism in the heart.

Autor: Chung YJ; School of Cardiovascular and Metabolic Medicine and Sciences, King's College, London, UK., Hoare Z; School of Cardiovascular and Metabolic Medicine and Sciences, King's College, London, UK., Baark F; School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK., Yu CS; MRC Mitochondrial Biology Unit and Department of Medicine, University of Cambridge, Cambridge, UK., Guo J; Institute of Cardiovascular Physiology, University Medical Centre, Göttingen, Germany., Fuller W; School of Cardiovascular and Metabolic Health, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Southworth R; School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK., Katschinski DM; Institute of Cardiovascular Physiology, University Medical Centre, Göttingen, Germany., Murphy MP; MRC Mitochondrial Biology Unit and Department of Medicine, University of Cambridge, Cambridge, UK., Eykyn TR; School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK. thomas.eykyn@kcl.ac.uk., Shattock MJ; School of Cardiovascular and Metabolic Medicine and Sciences, King's College, London, UK. michael.shattock@kcl.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2024 May 20; Vol. 15 (1), pp. 4277. Date of Electronic Publication: 2024 May 20.

IDH3γ functions as a redox switch regulating mitochondrial energy metabolism and contractility in the heart.

Autor: Nanadikar MS; Institute of Cardiovascular Physiology, University Medical Center Göttingen, Georg-August, University Göttingen, 37073, Göttingen, Germany., Vergel Leon AM; Institute of Cardiovascular Physiology, University Medical Center Göttingen, Georg-August, University Göttingen, 37073, Göttingen, Germany., Guo J; Institute of Cardiovascular Physiology, University Medical Center Göttingen, Georg-August, University Göttingen, 37073, Göttingen, Germany., van Belle GJ; Institute of Cardiovascular Physiology, University Medical Center Göttingen, Georg-August, University Göttingen, 37073, Göttingen, Germany., Jatho A; Institute of Cardiovascular Physiology, University Medical Center Göttingen, Georg-August, University Göttingen, 37073, Göttingen, Germany., Philip ES; Institute of Cardiovascular Physiology, University Medical Center Göttingen, Georg-August, University Göttingen, 37073, Göttingen, Germany., Brandner AF; Computational Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058, Erlangen, Germany.; Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK., Böckmann RA; Computational Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91058, Erlangen, Germany.; Erlangen National High-Performance Computing Center (NHR@FAU), Erlangen, Germany., Shi R; Institute of Cardiovascular Physiology, University Medical Center Göttingen, Georg-August, University Göttingen, 37073, Göttingen, Germany., Zieseniss A; Institute of Cardiovascular Physiology, University Medical Center Göttingen, Georg-August, University Göttingen, 37073, Göttingen, Germany., Siemssen CM; Institute of Cardiovascular Physiology, University Medical Center Göttingen, Georg-August, University Göttingen, 37073, Göttingen, Germany., Dettmer K; Institute of Functional Genomics, University of Regensburg, 93053, Regensburg, Germany., Brodesser S; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), 50931, Cologne, Germany., Schmidtendorf M; University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), 50931, Cologne, Germany., Lee J; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA., Wu H; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA., Furdui CM; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA., Brandenburg S; Clinic of Cardiology & Pneumology, University Medical Center Göttingen, Göttingen, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Göttingen, Göttingen, Germany., Burgoyne JR; King's College London, School of Cardiovascular Medicine & Sciences, The British Heart Foundation Centre of Excellence, SE1 7EH, London, UK., Bogeski I; Institute of Cardiovascular Physiology, University Medical Center Göttingen, Georg-August, University Göttingen, 37073, Göttingen, Germany., Riemer J; Institute for Biochemistry, Redox Metabolism and CECAD, University of Cologne, 50674, Cologne, Germany., Chowdhury A; Institute of Cellular Biochemistry, University Medical Center Göttingen, 37073, Göttingen, Germany., Rehling P; Institute of Cellular Biochemistry, University Medical Center Göttingen, 37073, Göttingen, Germany.; Cluster of Excellence, Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells (MBExC), University of Göttingen, Göttingen, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Translational Neuroinflammation and Automated Microscopy, Göttingen, Germany.; Max Planck Institute for Multidisciplinary Sciences, 37077, Göttingen, Germany., Bruegmann T; Institute of Cardiovascular Physiology, University Medical Center Göttingen, Georg-August, University Göttingen, 37073, Göttingen, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Göttingen, Göttingen, Germany.; Cluster of Excellence, Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells (MBExC), University of Göttingen, Göttingen, Germany., Belousov VV; Institute of Cardiovascular Physiology, University Medical Center Göttingen, Georg-August, University Göttingen, 37073, Göttingen, Germany.; Federal Center of Brain Research and Neurotechnologies, Federal Medical Agency, 117997, Moscow, Russia., Katschinski DM; Institute of Cardiovascular Physiology, University Medical Center Göttingen, Georg-August, University Göttingen, 37073, Göttingen, Germany. doerthe.katschinski@med.uni-goettingen.de.; DZHK (German Center for Cardiovascular Research), Partner Site Göttingen, Göttingen, Germany. doerthe.katschinski@med.uni-goettingen.de.

Publikováno v: Nature communications [Nat Commun] 2023 Apr 14; Vol. 14 (1), pp. 2123. Date of Electronic Publication: 2023 Apr 14.

MCU controls melanoma progression through a redox-controlled phenotype switch.

Autor: Stejerean-Todoran I; Molecular Physiology, Department of Cardiovascular Physiology, University Medical Center, Georg-August-University, Göttingen, Germany., Zimmermann K; Biophysics, CIPMM, Saarland University, Homburg, Germany., Gibhardt CS; Molecular Physiology, Department of Cardiovascular Physiology, University Medical Center, Georg-August-University, Göttingen, Germany., Vultur A; Molecular Physiology, Department of Cardiovascular Physiology, University Medical Center, Georg-August-University, Göttingen, Germany.; The Wistar Institute, Melanoma Research Center, Philadelphia, PA, USA., Ickes C; Molecular Physiology, Department of Cardiovascular Physiology, University Medical Center, Georg-August-University, Göttingen, Germany., Shannan B; The Wistar Institute, Melanoma Research Center, Philadelphia, PA, USA.; Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium (DKTK)., Bonilla Del Rio Z; Molecular Physiology, Department of Cardiovascular Physiology, University Medical Center, Georg-August-University, Göttingen, Germany., Wölling A; Department of Dermatology, Venereology and Allergology, University Medical Center, Georg-August-University, Göttingen, Germany., Cappello S; Molecular Physiology, Department of Cardiovascular Physiology, University Medical Center, Georg-August-University, Göttingen, Germany., Sung HM; Molecular Physiology, Department of Cardiovascular Physiology, University Medical Center, Georg-August-University, Göttingen, Germany., Shumanska M; Molecular Physiology, Department of Cardiovascular Physiology, University Medical Center, Georg-August-University, Göttingen, Germany., Zhang X; Molecular Physiology, Department of Cardiovascular Physiology, University Medical Center, Georg-August-University, Göttingen, Germany., Nanadikar M; Department of Cardiovascular Physiology, University Medical Center Göttingen, Georg-August-University, Göttingen, Germany., Latif MU; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Göttingen, Gottingen, Germany., Wittek A; Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Clinic of Neurology, University Medical Center Göttingen, Göttingen, Germany., Lange F; Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Clinic of Neurology, University Medical Center Göttingen, Göttingen, Germany., Waters A; The Wistar Institute, Melanoma Research Center, Philadelphia, PA, USA., Brafford P; The Wistar Institute, Melanoma Research Center, Philadelphia, PA, USA., Wilting J; Department of Anatomy and Cell Biology, University Medical Center, Georg-August-University, Göttingen, Germany., Urlaub H; Bioanalytical Mass Spectrometry Group, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Bioanalytics, Institute of Clinical Chemistry, University Medical Center, Göttingen, Germany., Katschinski DM; Department of Cardiovascular Physiology, University Medical Center Göttingen, Georg-August-University, Göttingen, Germany., Rehling P; Department of Cellular Biochemistry, University Medical Center Göttingen, GZMB, Göttingen, Germany., Lenz C; Bioanalytical Mass Spectrometry Group, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Bioanalytics, Institute of Clinical Chemistry, University Medical Center, Göttingen, Germany., Jakobs S; Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Clinic of Neurology, University Medical Center Göttingen, Göttingen, Germany., Ellenrieder V; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Göttingen, Gottingen, Germany., Roesch A; Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium (DKTK)., Schön MP; Department of Dermatology, Venereology and Allergology, University Medical Center, Georg-August-University, Göttingen, Germany., Herlyn M; The Wistar Institute, Melanoma Research Center, Philadelphia, PA, USA., Stanisz H; Department of Dermatology, Venereology and Allergology, University Medical Center, Georg-August-University, Göttingen, Germany., Bogeski I; Molecular Physiology, Department of Cardiovascular Physiology, University Medical Center, Georg-August-University, Göttingen, Germany.

Publikováno v: EMBO reports [EMBO Rep] 2022 Nov 07; Vol. 23 (11), pp. e54746. Date of Electronic Publication: 2022 Sep 26.

The HIFα-Stabilizing Drug Roxadustat Increases the Number of Renal Epo-Producing Sca-1 ⁺ Cells.

Autor: Jatho A; Institute of Cardiovascular Physiology, University Medical Center Göttingen, Georg-August-University Göttingen, 37073 Goettingen, Germany., Zieseniss A; Institute of Cardiovascular Physiology, University Medical Center Göttingen, Georg-August-University Göttingen, 37073 Goettingen, Germany., Brechtel-Curth K; Institute of Cardiovascular Physiology, University Medical Center Göttingen, Georg-August-University Göttingen, 37073 Goettingen, Germany., Guo J; Institute of Cardiovascular Physiology, University Medical Center Göttingen, Georg-August-University Göttingen, 37073 Goettingen, Germany., Böker KO; Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Göttingen, Georg-August-University Göttingen, 37075 Goettingen, Germany., Salinas G; NGS-Integrative Genomics Core Unit (NIG), Institute of Human Genetics, University Medical Center Göttingen, Georg-August-University Göttingen, 37073 Goettingen, Germany., Wenger RH; National Centre of Competence in Research 'Kidney.CH', 8057 Zurich, Switzerland.; Institute of Physiology, University of Zürich, 8057 Zurich, Switzerland., Katschinski DM; Institute of Cardiovascular Physiology, University Medical Center Göttingen, Georg-August-University Göttingen, 37073 Goettingen, Germany.

Publikováno v: Cells [Cells] 2022 Feb 21; Vol. 11 (4). Date of Electronic Publication: 2022 Feb 21.