Výsledky vyhledávání

Ultraviolet B radiation-induced skin cancer in mice defective in the Xpc, Trp53, and Apex (HAP1) genes: genotype-specific effects on cancer predisposition and pathology of tumors

Autor: Dl, Cheo, Lisiane Meira, Dk, Burns, Am, Reis, Issac T, Ec, Friedberg

Publikováno v: Europe PubMed Central

Mutations in nucleotide excision repair (NER) genes in humans result in the UV-induced skin cancer-prone disease xeroderma pigmentosum (XP). Mouse models that mimic XP have provided an informative experimental system with which to study DNA repair, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::22d07f58856e057a124aaab5bf563586
https://pubmed.ncbi.nlm.nih.gov/10749126

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Genotype-specific Trp53 mutational analysis in ultraviolet B radiation-induced skin cancers in Xpc and Xpc Trp53 mutant mice

Autor: Am, Reis, Dl, Cheo, Lisiane Meira, Ms, Greenblatt, Jp, Bond, Nahari D, Ec, Friedberg

Publikováno v: Europe PubMed Central

We have examined the mutational spectrum in the Trp53 gene from UVB radiation-induced skin cancers in Trp53+/+ and Trp53+/- mutant mice of all three possible Xpc genotypes. Mutations were detected in exons 2-10 of the Trp53 coding region in approxima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c0ceb0fb67c7eebb757ae19a72f5db74
https://pubmed.ncbi.nlm.nih.gov/10749125

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Mutational inactivation of the xeroderma pigmentosum group C gene confers predisposition to 2-acetylaminofluorene-induced liver and lung cancer and to spontaneous testicular cancer in Trp53-/- mice

Autor: Dl, Cheo, Dk, Burns, Lisiane Meira, Jf, Houle, Ec, Friedberg

Publikováno v: Europe PubMed Central

Mice that are genetically engineered to mimic the human hereditary cancer-prone DNA repair-defective disease xeroderma pigmentosum (XP) are highly predisposed to UV radiation-induced skin cancer. It is not clear, however, whether XP mice or humans ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3f1f6d8f51a7d76fb3051b912c120db8
http://europepmc.org/abstract/med/10029060

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Akademický článek

Feasibility of genome-scale construction of promoter::reporter gene fusions for expression in Caenorhabditis elegans using a multisite gateway recombination system.

Autor: Hope IA; School of Biology, University of Leeds, Leeds, LS2 9JT, UK. i.a.hope@leeds.ac.uk, Stevens J, Garner A, Hayes J, Cheo DL, Brasch MA, Vidal M

Publikováno v: Genome research [Genome Res] 2004 Oct; Vol. 14 (10B), pp. 2070-5.

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Akademický článek

Concerted assembly and cloning of multiple DNA segments using in vitro site-specific recombination: functional analysis of multi-segment expression clones.

Autor: Cheo DL; Atto Bioscience Inc., Rockville, Maryland 20850, USA., Titus SA, Byrd DR, Hartley JL, Temple GF, Brasch MA

Publikováno v: Genome research [Genome Res] 2004 Oct; Vol. 14 (10B), pp. 2111-20.

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Akademický článek

Use of nucleotide excision repair-deficient mice as a model for chemically induced lung cancer.

Autor: Cheo DL; Life Technologies Division, Invitrogen Corporation, Rockville, MD, USA., Friedberg EC

Publikováno v: Methods in molecular medicine [Methods Mol Med] 2003; Vol. 74, pp. 481-91.

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Akademický článek

Mice defective in the mismatch repair gene Msh2 show increased predisposition to UVB radiation-induced skin cancer.

Autor: Meira LB; Laboratory of Molecular Pathology, Department of Pathology, Southwestern Medical Center, University of Texas, Dallas, TX 75235, USA., Cheo DL, Reis AM, Claij N, Burns DK, te Riele H, Friedberg EC

Publikováno v: DNA repair [DNA Repair (Amst)] 2002 Nov 03; Vol. 1 (11), pp. 929-34.

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Akademický článek

The DNA damage signal for Mdm2 regulation, Trp53 induction, and sunburn cell formation in vivo originates from actively transcribed genes.

Autor: Brash DE; Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Conneticut 06520-8040, USA. douglas.brash@yale.edu, Wikonkal NM, Remenyik E, van der Horst GT, Friedberg EC, Cheo DL, van Steeg H, Westerman A, van Kranen HJ

Publikováno v: The Journal of investigative dermatology [J Invest Dermatol] 2001 Nov; Vol. 117 (5), pp. 1234-40.

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Akademický článek

Cancer predisposition in mutant mice defective in multiple genetic pathways: uncovering important genetic interactions.

Autor: Meira LB; Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Reis AM, Cheo DL, Nahari D, Burns DK, Friedberg EC

Publikováno v: Mutation research [Mutat Res] 2001 Jun 02; Vol. 477 (1-2), pp. 51-8.

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Akademický článek

Defective nucleotide excision repair in xpc mutant mice and its association with cancer predisposition.

Autor: Friedberg EC; Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA. friedberg.erro1@pathology.swmed.edu, Bond JP, Burns DK, Cheo DL, Greenblatt MS, Meira LB, Nahari D, Reis AM

Publikováno v: Mutation research [Mutat Res] 2000 Mar 20; Vol. 459 (2), pp. 99-108.

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