Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Djuro Karanovic"'
Autor:
Djuro Karanovic, Ian C. Michelow, Anthony R. Hayward, Suk See DeRavin, Ottavia M. Delmonte, Michael E. Grigg, Adam Kerry Dobbs, Julie E. Niemela, Jennifer Stoddard, Zaid Alhinai, Natasha Rybak, Nancy Hernandez, Stefania Pittaluga, Sergio D. Rosenzweig, Gulbu Uzel, Luigi D. Notarangelo
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Phosphoinositide 3-kinase (PI3K) plays an integral role in lymphocyte function. Mutations in PIK3CD and PIK3R1, encoding the PI3K p110δ and p85α subunits, respectively, cause increased PI3K activity and result in immunodeficiency with immune dysreg
Externí odkaz:
https://doaj.org/article/91e24ad155c14f3995e7c86499bc37f9
Autor:
Andreas Varkaris, Erika Hamilton, Jason Henry, Alexander I. Spira, Alison M. Schram, Julia E. McGuinness, Gege Tan, Xiaoyan Li, Tamieka Hunter, Ramin Samadani, Alison Timm, Djuro Karanovic, Vivek Subbiah, Cesar A. Perez
Publikováno v:
Cancer Research. 83:OT3-22
Background: Targeting constitutively active mutant kinases with selective small molecule inhibitors is a key therapeutic pillar of precision oncology. Phosphatidylinositol-4,5bisphosphate-3 kinase, catalytic subunit alpha (PIK3CA) mutations leading t
Autor:
Jinshan Shen, Rishikesh Sawant, Rick Blakesley, Kai Yu Jen, Fabien Ricard, Xiaoyan Li, Cassandra Key, Djuro Karanovic
Publikováno v:
Cancer Research. 83:2795-2795
Background/Introduction: Effective therapies for FGFR2-driven cholangiocarcinoma (CCA) and other advanced solid tumors remain unmet medical needs. RLY-4008 is a potent, highly selective and irreversible FGFR2 inhibitor designed to target both primary
Autor:
Cesar Augusto Perez, Jason Timothy Henry, Andreas Varkaris, Vivek Subbiah, Alexander I. Spira, Oleg Schmidt, Jinshan Shen, Wei Guo, Tamieka Hunter, Kai Yu Jen, Mahesh Padval, Djuro Karanovic, Beni B. Wolf, Erika P. Hamilton
Publikováno v:
Journal of Clinical Oncology. 40:TPS1124-TPS1124
TPS1124 Background: Targeting constitutively active mutant kinases with selective small molecule inhibitors is a key therapeutic pillar of precision oncology. Phosphatidylinositol-4,5bisphosphate-3 kinase, catalytic subunit alpha ( PIK3CA) mutations
Autor:
Natasha Rybak, Julie E. Niemela, Stefania Pittaluga, Anthony R. Hayward, Ottavia M. Delmonte, Suk See DeRavin, Adam K. Dobbs, Gulbu Uzel, Jennifer Stoddard, Ian C. Michelow, Zaid Alhinai, Sergio D. Rosenzweig, Nancy Hernandez, Michael E. Grigg, Luigi D. Notarangelo, Djuro Karanovic
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology, Vol 10 (2019)
Phosphoinositide 3-kinase (PI3K) plays an integral role in lymphocyte function. Mutations in PIK3CD and PIK3R1, encoding the PI3K p110δ and p85α subunits, respectively, cause increased PI3K activity and result in immunodeficiency with immune dysreg
Autor:
Djuro Karanovic, Mitesh J. Borad, Diwakar Davar, Maria Schwaederle, Dmitriy Zamarin, Grace K. Dy, Danielle M. Townsley, Kevin J. Harrington, Evanthia Galanis, Beth Kelly
Publikováno v:
Cancer Research. 80:CT244-CT244
Background: Oncolytic viruses selectively infect tumors and activate antitumor immune responses via innate and adaptive pathways, which may potentiate the efficacy of immune checkpoint inhibitors. MEDI5395 is a recombinant Newcastle disease virus inc
Autor:
Amy Rump, Gulbu Uzel, Djuro Karanovic, V. Koneti Rao, Hua Su, Anahita Agharahimi, Steven M. Holland
Publikováno v:
Blood. 132:2409-2409
Background: CTLA4 is a homodimeric cell surface inhibitory receptor that plays a critical role in maintaining immune system homeostasis by suppressing T-lymphocyte activation and proliferation. Heterozygous germline, loss-of-function mutations in CTL
Autor:
Djuro Karanovic, Fuad Maufa, Jay Zeck, Lynt B. Johnson, Walid Chalhoub, Akash Ajmera, Mohamed Sultan, Shervin Shafa, Nadim Haddad
Publikováno v:
ACG Case Reports Journal
Enteric duplication cysts (EDCs) are benign congenital anomalies that are found incidentally in adults. Gastric duplication cysts (GDCs) are the least common subtype of EDC, but when located near the pancreas, may resemble other neoplastic conditions
Publikováno v:
Chest. 148:236A
Publikováno v:
Emergency medicine journal : EMJ. 29(1)
Objective The number of annual patient visits to US emergency departments (ED) has been increasing since 1995, whereas the number of ED is decreasing. Previous studies have identified many reasons why patients seek care in ED, including lack of acces