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New Imidazodiazepine Analogue, 5-(8-Bromo-6-(pyridin-2-yl)-4 H -benzo[ f ]imidazo[1,5- a ][1,4]diazepin-3-yl)oxazole, Provides a Simplified Synthetic Scheme, High Oral Plasma and Brain Exposures, and Produces Antiseizure Efficacy in Mice, and Antiepileptogenic Activity in Neural Networks in Brain Slices from a Patient with Mesial Temporal Lobe Epilepsy.

Autor: Sharmin D; Department of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States., Divović B; Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, Belgrade 11221, Serbia., Ping X; Department of Anatomy and Cell Biology, Indiana University/Purdue University, Indianapolis, Indiana 46202, United States., Cerne R; Department of Anatomy and Cell Biology, Indiana University/Purdue University, Indianapolis, Indiana 46202, United States.; Laboratory of Antiepileptic Drug Discovery, St. Vincent's Hospital, Indianapolis, Indiana 46260, United States.; RespireRx Pharmaceuticals Inc, Glen Rock, New Jersey 07452, United States.; Faculty of Medicine, University of Ljubljana, Zaloška cesta 4, Ljubljana 1000, Slovenia., Smith JL; Laboratory of Antiepileptic Drug Discovery, St. Vincent's Hospital, Indianapolis, Indiana 46260, United States., Rezvanian S; Department of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States., Mondal P; Department of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States., Meyer MJ; Department of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States., Kiley ME; Department of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States., Arnold LA; Department of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States., Mian MY; Department of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States., Pandey KP; Department of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States., Jin X; Department of Anatomy and Cell Biology, Indiana University/Purdue University, Indianapolis, Indiana 46202, United States., Mitrović JR; Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Belgrade 11221, Serbia., Djorović D; Institute of Anatomy, School of Medicine, University of Belgrade, Belgrade 11221, Serbia., Lippa A; RespireRx Pharmaceuticals Inc, Glen Rock, New Jersey 07452, United States., Cook JM; Department of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States.; RespireRx Pharmaceuticals Inc, Glen Rock, New Jersey 07452, United States., Golani LK; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States., Scholze P; Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Vienna 1090, Austria., Savić MM; Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, Belgrade 11221, Serbia., Witkin JM; Department of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States.; Laboratory of Antiepileptic Drug Discovery, St. Vincent's Hospital, Indianapolis, Indiana 46260, United States.; RespireRx Pharmaceuticals Inc, Glen Rock, New Jersey 07452, United States.

Publikováno v: ACS chemical neuroscience [ACS Chem Neurosci] 2024 Feb 07; Vol. 15 (3), pp. 517-526. Date of Electronic Publication: 2024 Jan 04.