Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Djordje, Musil"'
Autor:
Satenig Guler, Maria C. DiPoto, Alejandro Crespo, Richard Caldwell, Benjamin Doerfel, Nina Grossmann, Kevin Ho, Bayard Huck, Christopher CV Jones, Ruoxi Lan, Djordje Musil, Justin Potnick, Heike Schilke, Brian Sherer, Stephanie Simon, Christian Sirrenberg, Zhuo Zhang, Lesley Liu-Bujalski
Publikováno v:
ACS Medicinal Chemistry Letters. 14:566-576
Autor:
Dong Zhang, Feng Jiang, Rinat Zaynagetdinov, Hui Huang, Vanita D. Sood, Hong Wang, Xinyan Zhao, Molly H. Jenkins, Qingyong Ji, Youbin Wang, David P. Nannemann, Djordje Musil, John Wesolowski, Andrea Paoletti, Tin Bartholomew, Melissa G. Derner, Qi An, Christel Iffland, Joern-Peter Halle
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
T cell immunoglobulin and mucin domain-3 (TIM-3) is an immune checkpoint that regulates normal immune responses but can be exploited by tumor cells to evade immune surveillance. TIM-3 is primarily expressed on immune cells, particularly on dysfunctio
Externí odkaz:
https://doaj.org/article/f2420cb2a82040deb84b2167b543e3fe
Autor:
Timo Heinrich, Carl Peterson, Richard Schneider, Sakshi Garg, Daniel Schwarz, Jakub Gunera, Anita Seshire, Lisa Kötzner, Sarah Schlesiger, Djordje Musil, Heike Schilke, Benjamin Doerfel, Patrizia Diehl, Pia Böpple, Ana R. Lemos, Pedro M. F. Sousa, Filipe Freire, Tiago M. Bandeiras, Emma Carswell, Nicholas Pearson, Sameer Sirohi, Mollie Hooker, Elisabeth Trivier, Rebecca Broome, Alexander Balsiger, Abigail Crowden, Christian Dillon, Dirk Wienke
Publikováno v:
Journal of Medicinal Chemistry. 65:9206-9229
Autor:
Momar Toure, Constantin Neagu, Kevin Ho, Susan Zhang, Filippos Porichis, Zhizhou Fang, Maria DiPoto, Reinaldo Jones, Eugene Chekler, Eva Maria Tanzer, Brian Sherer, Theresa Johnson, Djordje Musil, Bin Li, Ralf Schmidt, Hong Ma, Andrea Unzue Lopez, Yanping Wang, Satenig Guler, YuFang Xiao, Renate Henkes, Chia Lin Chu, Uma Mahesh Gundra, Long Li, Christine Katharina Maurer, Emily Friis, Christopher Jones, James Cummings, Bayard Huck
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60c4b42c55d861e189da387afa4d82a1
https://doi.org/10.2139/ssrn.4382746
https://doi.org/10.2139/ssrn.4382746
Autor:
Felix Rohdich, Stefano Crosignani, Michael Busch, Christina Esdar, Manja Friese-Hamim, Markus Klein, Thomas Fuchss, Oliver Schadt, Djordje Musil, Ugo Zanelli, Michael P. Sanderson, Gina Walter-Bausch, Philip Hewitt, Jeyaprakashnarayanan Seenisamy
Publikováno v:
Journal of Medicinal Chemistry. 64:10230-10245
Proteasomes are broadly expressed key components of the ubiquitin-dependent protein degradation pathway containing catalytically active subunits (β1, β2, and β5). LMP7 (β5i) is a subunit of the immunoproteasome, an inducible isoform that is predo
Autor:
Anne Gigout, Daniela Werkmann, Stephanie Menges, Christian Brenneis, Frances Henson, Kyra J. Cowan, Djordje Musil, Christian S. Thudium, Hans Gühring, Martin Michaelis, Kerstin Kleinschmidt‐Doerr
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.)REFERENCES.
To preclinically characterize a mutant form of growth and differentiation factor 5, R399E, with reduced osteogenic properties as a potential disease-modifying osteoarthritis (OA) drug.Cartilage, synovium, and meniscus samples from patients with OA we
Discovery of M5049: A Novel Selective Toll-Like Receptor 7/8 Inhibitor for Treatment of Autoimmunity
Autor:
Melinda Przetak, Aditee Deshpande, Simone C. Zimmerli, Noune Tahmassian Morse, Evgeni Tzvetkov, Albertina Pereira, Sonja Reissig, Robert L. Walsky, Shinji L. Okitsu, Philipp Haselmayer, Djordje Musil, Sherer Brian A, Jaromir Vlach, Theresa L. Johnson, Andrew Bender
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 376:397-409
Toll-like receptor (TLR) 7 and TLR8 are transmembrane receptors that recognize single-stranded RNA. Activation of these receptors results in immune cell stimulation and inflammatory cytokine production, which is normally a protective host response. H
Autor:
Jeyaprakashnarayanan Seenisamy, Frank Becker, Djordje Musil, Jörg Bomke, Jakub Gunera, Uwe Eckert, Timo Heinrich, Felix Rohdich, Kerrin Hansen, Beatrix Blume, Christian Siegl, Frank Zenke, Jens Pfalzgraf, Dieter Spuck, Ansgar Wegener, Birgitta Leuthner, Melanie Dietz, Manja Friese-Hamim
Publikováno v:
Journal of Medicinal Chemistry. 62:11119-11134
The recently disclosed next generation of reversible, selective, and potent MetAP-2 inhibitors introduced a cyclic tartronic diamide scaffold. However, the lead compound 1a suffered from enterohepatic circulation, preventing further development. Neve
Autor:
Martin Lehmann, Djordje Musil, Daniel Kuhn, Richard Schneider, Daniela Radtki, Uwe Anlauf, Claudio Ritzert, Hans-Peter Buchstaller, Felix Rohdich, Christina Esdar, Dieter Dorsch, Birgitta Leuthner
Publikováno v:
Journal of Medicinal Chemistry. 62:7897-7909
Tankyrases 1 and 2 (TNKS1/2) are promising pharmacological targets that recently gained interest for anticancer therapy in Wnt pathway dependent tumors. 2-Aryl-quinazolinones were identified and optimized into potent tankyrase inhibitors through SAR
Autor:
Stefanie Gaus, Djordje Musil, Ugo Zanelli, Felix Rohdich, Markus Klein, Oliver Schadt, Michael Busch, Gina Walter-Bausch, Manja Friese-Hamim, Sondra L. Downey-Kopyscinski, Michael P. Sanderson, Christina Esdar, Constantine S. Mitsiades
Publikováno v:
Molecular cancer therapeutics. 20(8)
Large multifunctional peptidase 7 (LMP7/β5i/PSMB8) is a proteolytic subunit of the immunoproteasome, which is predominantly expressed in normal and malignant hematolymphoid cells, including multiple myeloma, and contributes to the degradation of ubi