Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Djemel Aït-Azzouzene"'
Autor:
Kevin Walsh, Amanda L. Gavin, Miyo Aoki-Ota, David Nemazee, Bao Hoa Duong, Djemel Aït-Azzouzene, Takayuki Ota, Jose Luis Vela, Christoph Huber
Publikováno v:
The Journal of Immunology. 184:4143-4158
Transitional B cells turn over rapidly in vivo and are sensitive to apoptosis upon BCR ligation in vitro. However, little direct evidence addresses their tolerance sensitivity in vivo. A key marker used to distinguish these cells is IgD, which, throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87566fee08b128951950f07d373d147a
https://doi.org/10.4049/jimmunol.0903564
https://doi.org/10.4049/jimmunol.0903564
Publikováno v:
Immunity. 28(2):161-170
Summary The recombining sequence (RS) of mouse and its human equivalent, the immunoglobulin (Ig) kappa deleting element ( IGKDE ), are sequences found at the 3′ end of the Ig kappa locus ( Igk ) that rearrange to inactivate Igk in developing B cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4846ca1d079cceb6e78eadab5efd8497
Autor:
Bao Duong, Kamal D. Puri, David Nemazee, Laurent Verkoczy, Djemel Aït-Azzouzene, Patrick Skog, Jose Luis Vela
Publikováno v:
The Journal of Immunology. 178:6332-6341
PI3K plays key roles in cell growth, differentiation, and survival by generating the second messenger phosphatidylinositol-(3,4,5)-trisphosphate (PIP3). PIP3 activates numerous enzymes, in part by recruiting them from the cytosol to the plasma membra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e84e0c96610f162b98ba06617d9c134
https://doi.org/10.4049/jimmunol.178.10.6332
https://doi.org/10.4049/jimmunol.178.10.6332
Publikováno v:
European Journal of Immunology. 36:985-996
In mice carrying a synthetic Igkappa-reactive superantigen ("kappa macroself antigen"), low level expression induced split peripheral B cell tolerance in the sIgkappa+ compartment, with striking reductions in follicular and marginal zone (MZ) B cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031540f75f3b302ed97e86487a83e77d
https://doi.org/10.1002/eji.200535581
https://doi.org/10.1002/eji.200535581
Autor:
Patrick Skog, Laurent Verkoczy, Djemel Aït-Azzouzene, Amanda L. Gavin, David Nemazee, Bao Duong
Publikováno v:
The Journal of Immunology. 176:939-948
Peripheral B cell tolerance differs from central tolerance in anatomic location, in the stage of B cell development, and in the diversity of Ag-responsive cells. B cells in secondary lymphoid organs are heterogeneous, including numerous subtypes such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a36f1170d4797ea63c1e9bdd0b793426
https://doi.org/10.4049/jimmunol.176.2.939
https://doi.org/10.4049/jimmunol.176.2.939
Autor:
Amanda, Gavin, Djemel, Aït-Azzouzene, Annica, Mårtensson, Bao, Duong, Laurent, Verkoczy, José Luis, Vela, José Luis, Skog, Patrick, Skog, David, Nemazee
Publikováno v:
The Keio Journal of Medicine. 53:151-158
This lecture discusses two interrelated topics, B cell tolerance in the peripheral immune system and BAFF. Using the 3-83 antibody transgenic mouse bred to mice carrying cognate antigen in the liver, we previously found that clonal elimination drasti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b57bff5005f3eb21c6635a46d3f946b7
https://doi.org/10.2302/kjm.53.151
https://doi.org/10.2302/kjm.53.151
Publikováno v:
Journal of Biological Chemistry. 278:38220-38228
The tumor necrosis family member BAFF is limiting for the survival of follicular B lymphocytes, but excessive BAFF signaling can lead to autoimmunity, suggesting that its activity must be tightly regulated. We have identified a conserved alternate sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c01bf8a8f0399c07ffcf0a33cc1640
https://doi.org/10.1074/jbc.m306852200
https://doi.org/10.1074/jbc.m306852200
Autor:
Colette Kanellopoulos-Langevin, Françoise Tchang, Marie-Claude Gendron, Stéphane M. Caucheteux, Djemel Aït-Azzouzene, Anja Langkopf, R. Moutier, Josiane Wantyghem
Publikováno v:
Biology of Reproduction. 65:337-344
We have produced transgenic mice using the mouse placental lactogen type II promoter to force and restrict the expression of the mouse major histocompatibility complex (MHC) class I molecule, H-2K b , to the placenta. We show that the transgenic MHC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1a63bca90a490411a3b46e88d50329c
https://doi.org/10.1095/biolreprod65.2.337
https://doi.org/10.1095/biolreprod65.2.337
Autor:
Colette Kanellopoulos-Langevin, Christian Bleux, José L. Cohen, Marie-Claude Gendron, Djemel Aït-Azzouzene, Anja Langkopf
Publikováno v:
Molecular Reproduction and Development. 50:35-44
Among the numerous hypotheses proposed to explain the absence of fetal rejection by the mother in mammals, it has been suggested that regulation of expression of the polymorphic major histocompatibility complex (MHC) at the fetal-maternal interface p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffbb987a7b8d6031079216b9f566a56b
https://doi.org/10.1002/(sici)1098-2795(199805)50:1<35::aid-mrd5>3.0.co
https://doi.org/10.1002/(sici)1098-2795(199805)50:1<35::aid-mrd5>3.0.co
Autor:
David Nemazee, Takayuki Ota, Anthony B. Cooper, Djemel Aït-Azzouzene, Miyo Aoki-Ota, Amanda L. Gavin, Bao Hoa Duong, Jose Luis Vela
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 187(11)
To analyze B lymphocyte central tolerance in a polyclonal immune system, mice were engineered to express a superantigen reactive to IgM of allotype b (IgMb). IgMb/b mice carrying superantigen were severely B cell lymphopenic, but small numbers of B c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f7a305e1295d4232b3eb24f2e390f0
https://pubmed.ncbi.nlm.nih.gov/22043016
https://pubmed.ncbi.nlm.nih.gov/22043016