Výsledky vyhledávání - "Djamila Harouaka"

Lessons from CDER’s Quality Management Maturity Pilot Programs

Autor: Jennifer Maguire, Adam Fisher, Djamila Harouaka, Nandini Rakala, Carla Lundi, Marcus Yambot, Alex Viehmann, Neil Stiber, Kevin Gonzalez, Lyle Canida, Lucinda Buhse, Michael Kopcha

Publikováno v: The AAPS Journal. 25

Between October 2020 and March 2022, FDA’s Center for Drug Evaluation and Research (CDER) completed two pilot programs to assess the quality management maturity (QMM) of drug manufacturing establishments. Mature quality systems promote proactive de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b8c1414df106c7a088b7a6f65762e2c
https://doi.org/10.1208/s12248-022-00777-z

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Diminished viral replication and compartmentalization of hepatitis C virus in hepatocellular carcinoma tissue

Autor: Fausto Zamboni, Harvey J. Alter, Kurt Wollenberg, Djamila Harouaka, Ronald E. Engle, Sugantha Govindarajan, Patrizia Farci, Ashley Tice, David E. Kleiner, Giacomo Diaz

Publikováno v: Proceedings of the National Academy of Sciences. 113:1375-1380

Analysis of hepatitis C virus (HCV) replication and quasispecies distribution within the tumor of patients with HCV-associated hepatocellular carcinoma (HCC) can provide insight into the role of HCV in hepatocarcinogenesis and, conversely, the effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c50105388e1f39d1558ea8df3d253bb8
https://doi.org/10.1073/pnas.1516879113

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Mutations in the C-Terminal Loop of the Nucleocapsid Protein Affect Vesicular Stomatitis Virus RNA Replication and Transcription Differentially

Autor: Djamila Harouaka, Gail W. Wertz

Publikováno v: Journal of Virology. 83:11429-11439

The 2.9-Å structure of the vesicular stomatitis virus nucleocapsid (N) protein bound to RNA shows the RNA to be tightly sequestered between the two lobes of the N protein. Domain movement of the lobes of the N protein has been postulated to facilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac70eb8569d249b66438a3758bc05b37
https://doi.org/10.1128/jvi.00813-09

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Second-site mutations selected in transcriptional regulatory sequences compensate for engineered mutations in the vesicular stomatitis virus nucleocapsid protein

Autor: Djamila Harouaka, Gail W. Wertz

Publikováno v: Journal of virology. 86(20)

The active template for RNA synthesis for vesicular stomatitis virus (VSV) and other negative-strand viruses is the RNA genome in association with the nucleocapsid (N) protein. The N protein molecules sequester the genomic RNA and are linked together

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1d845c0c74e42cc274a4bf17e6acc5
https://pubmed.ncbi.nlm.nih.gov/22875970

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What Controls the Distinct VSV RNA Synthetic Processes of Replication and Transcription?

Autor: Djamila Harouaka, Summer E. Galloway, Gail W. Wertz

Publikováno v: Negative Strand RNA Virus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87d617f7886fd1cefa6be74827ea8c51
https://doi.org/10.1142/9789814317238_0004

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Importance of Hydrogen Bond Contacts between the N Protein and RNA Genome of Vesicular Stomatitis Virus in Encapsidation and RNA Synthesis▿

Autor: Djamila Harouaka, Gail W. Wertz, Edward W. Rainsford

Vesicular stomatitis virus (VSV) genomic RNA encapsidated by the nucleocapsid (N) protein is the template for transcription and replication by the viral polymerase. We analyzed the 2.9-Å structure of the VSV N protein bound to RNA (T. J. Green, X.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0348e2d1921d42b2a6b3aa01d6148830
https://europepmc.org/articles/PMC2812390/

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