Zobrazeno 1 - 10 of 325 pro vyhledávání: '"Dj, Veale"'
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P067 Tofacitinib impairs monocyte-derived dendritic cell differentiation in rheumatoid arthritisand psoriatic arthritis
Autor: Ursula Fearon, Candice Low, Mary Canavan, Viviana Marzaioli, S. Wade, DJ Veale, Achilleas Floudas
Publikováno v: Abstracts.
Background Tofacinitib (Pfizer) is an oral Janus kinase inhibitor, recently approved for the treatment of rheumatoid arthritis (RA). Although its mechanism of action has been explored in circulating cells, in particular neutrophils and lymphocyte, it
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c75935c034048cbf351e8cb5b2f9b1e
https://doi.org/10.1136/annrheumdis-2018-ewrr2019.56
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2
P068 Rheumatoid arthritis peripheral CD14+ monocytes are hyper-inflammatory, hyper-glycolytic and retain a memory bias toward m1 macrophages
Autor: M. Hanlon, Ursula Fearon, DJ Veale, Trudy McGarry
Publikováno v: Abstracts.
Career situation of first and presenting author Post-doctoral fellow. Introduction Myeloid cells with a monocyte/macrophages phenotype are present in large numbers in the rheumatoid arthritis (RA) joint, significantly contributing to disease. Objecti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a806cf871a9d7f80d08cc5d0bd45051
https://doi.org/10.1136/annrheumdis-2018-ewrr2019.57
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4
P077 Dysregulated miR-125a promotes joint angiogenesis through enhanced glycolysis
Autor: Mary Canavan, Breandán N. Kennedy, DJ Veale, Ursula Fearon, Trudy McGarry, H McLaouglin, N Ohnesorge, Sarah M. Wade, M Biniecka
Publikováno v: Abstracts.
Career situation of first and presenting author Post-doctoral fellow. Introduction Psoriatic arthritis (PsA) is characterised by an early vascular phase essential for pannus growth, immune responses and disease progression. Recently, numerous studies
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::378f9660fbef6fc01cd15d820d8bd238
https://doi.org/10.1136/annrheumdis-2018-ewrr2019.66
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5
POS1216 SYMPTOM RATES, ATTITUDES AND MEDICATION ADHERENCE OF RHEUMATIC AND MUSCULOSKELETAL DISEASE PATIENTS DURING THE SARS-CoV2 PANDEMIC
Autor: Anna O'Rourke, Matthew A. Turk, Lorraine O'Neill, S. Quinn, Ursula Fearon, Anne-Barbara Mongey, DJ Veale, Kieran Murray, E. Molloy
Publikováno v: Annals of the Rheumatic Diseases. 80:891.2-892
Background:SARS-CoV2 has caused over two million deaths globally. The relationship between rheumatic and musculoskeletal disease (RMDs), immunosuppressive medications and COVID-19 is unclear.Objectives:This study explores the rates of COVID-19 sympto
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50d2fafea2e585a20a8278f5fe30bb92
https://doi.org/10.1136/annrheumdis-2021-eular.2579
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6
POS0069 INCREASED T CELL RESPONSES, METABOLIC ACTIVITY AND FIBROBLAST INVASIVE CAPACITY IN CHILDREN WITH DOWN’S SYNDROME-ASSOCIATED ARTHRITIS COMPARED TO JUVENILE IDIOPATHIC ARTHRITIS
Autor: D. Deely, S. Foo, Ursula Fearon, S Ansboro, E.J. MacDermott, Ronan H Mullan, DJ Veale, A. O’ Brien, Achilleas Floudas, Charlene Foley, S. Wade, O. Killeen
Publikováno v: Annals of the Rheumatic Diseases. 80:241.1-241
Background:Juvenile idiopathic arthritis (JIA) was thought to be the most common inflammatory arthritis in children (Shih et al., 2019). However an aggressive, erosive arthritis of little-known immunologic mechanism occurs 20 times more frequently in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::112c0c94d57b1ad54c40e555399aeee5
https://doi.org/10.1136/annrheumdis-2021-eular.2104
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7
THU0081 MIR-17-5P REDUCES INFLAMMATION AND BONE EROSIONS IN COLLAGEN INDUCED ARTHRITIS MICE AND DIRECTLY TARGETS THE JAK-STAT PATHWAY IN RHEUMATOID ARTHRITIS FIBROBLAST-LIKE SYNOVIOCYTES
Autor: Ursula Fearon, Benjamin Ory, Frédéric Blanchard, P. Preuss, Steven Georges, B. Le Goff, DJ Veale, Thibaut Quillard, F. M. Masson, Aurélie Najm
Publikováno v: Annals of the Rheumatic Diseases. 79:252.2-253
Background:micro-RNAs (miR) are strong regulators of gene expression. Their involvement in RA key cytokines pathway regulation entitles them as important players in RA pathophysiology. The miR 17-92 cluster has been widely studied in cancer as they r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d5cdaf48efd1be56ee66137d0dc6bf5
https://doi.org/10.1136/annrheumdis-2020-eular.314
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8
OP0314 B cell phenotype and function in the synovium of acpa+ and acpa- rheumatoid arthritispatients
Autor: DJ Veale, Candice Low, Monika Biniecka, Achilleas Floudas, Ursula Fearon
Publikováno v: FRIDAY, 15 JUNE 2018.
Background Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of unknown and complex etiology with severe detrimental effects for the patient’s quality of life. While rheumatoid factors (RF) and anti-citrulinated protein antibod
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8032ac3e2eecdf62bd927dbead211ef3
https://doi.org/10.1136/annrheumdis-2018-eular.4835
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9
SAT0087 Association of biometrics with disease characteristics and synovial phenotype in inflammatory arthritis
Autor: DJ Veale, Candice Low, Monika Biniecka, Kieran Murray, Ursula Fearon, Francis Young, Richard Conway, Hannah Convery
Publikováno v: Saturday, 16 JUNE 2018.
Background The potential importance of altered body composition in the development of and disease course in inflammatory arthritis is increasingly being recognised. Body composition in different types of inflammatory arthritis and its influence on sy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74f81ba56da8b54c99819a70e1905130
https://doi.org/10.1136/annrheumdis-2018-eular.5796
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10
SAT0542 Interleukin-12 and interleukin-23 are key pathogenic players in giant cell arteritis
Autor: Lorraine O'Neill, Conor Murphy, Ursula Fearon, DJ Veale, Geraldine M. McCarthy, P. Gallagher, E. Molloy, Richard Conway
Publikováno v: Saturday, 16 JUNE 2018.
Background Giant cell arteritis (GCA) is the most common form of systemic vasculitis; the pathogenesis is unclear. Current evidence suggests both the TH1 and TH17 pathways are important but the proximal initiators and effector cytokines are unknown.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbd23e8157496a7ad4cc2ae3722140d0
https://doi.org/10.1136/annrheumdis-2018-eular.2850
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