Mechanisms of drug hypersensitivity in HIV-infected patients: the role of the immune system

Autor: Fj, Vilar, Dj, Naisbitt, Bk, Park, Munir Pirmohamed

Publikováno v: Europe PubMed Central

Drug hypersensitivity is a major problem in HIV medicine. These reactions limit the choice of antiretrovirals that can be used in a patient and, at times, can lead to failure to administer an adequate regimen. Hypersensitivity reactions occur in a mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::35c3de9c753c96264c7843e41f591a46
https://pubmed.ncbi.nlm.nih.gov/12838164

Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: possible role in agranulocytosis

Autor: Dp, Williams, Munir Pirmohamed, Dj, Naisbitt, Jl, Maggs, Bk, Park

Publikováno v: Europe PubMed Central

Clozapine is associated with a 0.8% incidence of agranulocytosis. Bioactivation to an unstable protein-reactive metabolite, identified as a nitrenium intermediate, has been implicated in the toxicity. In this study, we investigated whether the reacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a127654181abf00334d15e737173efb8
http://europepmc.org/abstract/med/9400013

Feedback regulation of VISTA and Treg by TNF-α controls T cell responses in drug allergy.

Autor: Sun L; Hospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China., Zhao Q; Hospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China., Ao S; Hospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China., Liu T; Hospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China., Wang Z; Hospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China., You J; Hospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China., Mi Z; Hospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China., Sun Y; Hospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China., Xue X; Hospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China., Ogese MO; MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutic, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Gardner J; MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutic, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Meng X; MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutic, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Naisbitt DJ; MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutic, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Liu H; Hospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China.; School of Public Health, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China., Zhang F; Hospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China.; School of Public Health, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.; Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.

Publikováno v: Allergy [Allergy] 2024 Nov 11. Date of Electronic Publication: 2024 Nov 11.

Immune checkpoint blockade lowers the threshold of naïve T-cell priming to drug-associated antigens in a dose-dependent fashion.

Autor: Grice S; Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L69 3GE, United Kingdom., Saide K; Clinical Pharmacology and Safety Science, AstraZeneca, Cambridge, United Kingdom., Farrell L; Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L69 3GE, United Kingdom., Wells G; Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L69 3GE, United Kingdom., Betts C; Clinical Pharmacology and Safety Science, AstraZeneca, Cambridge, United Kingdom., Hammond S; ApconiX, Alderley Edge SK10 4TG, United Kingdom., Naisbitt DJ; Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L69 3GE, United Kingdom.

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2024 Nov 01; Vol. 202 (1), pp. 13-18.

Pathomechanism of Adverse Reactions to Biological Treatment of Inflammatory Skin Conditions.

Autor: Li L; Hospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China., Naisbitt DJ; MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK., Sun Y; Hospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China., Zhang F; Hospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China.

Publikováno v: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology [Clin Exp Allergy] 2024 Oct 20. Date of Electronic Publication: 2024 Oct 20.