Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway

Autor: Badolato R, Ja, Johnston, Jm, Wang, Daniel McVicar, Ll, Xu, Jj, Oppenheim, Dj, Kelvin

Publikováno v: Europe PubMed Central

We have previously reported that serum amyloid A (SAA) induces adhesion and chemotaxis of human monocytes and polymorphonuclear neutrophils, in vitro as well as in vivo. Since the mechanism of SAA signaling is unknown, we have investigated the possib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cf87896677c60add0dbae8b6ef8b664a
https://pubmed.ncbi.nlm.nih.gov/7561109

Formulation of next-generation polyvalent vaccine candidates against three important poxviruses by targeting DNA-dependent RNA polymerase using an integrated immunoinformatics and molecular modeling approach.

Autor: Kumar A; Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Canada; Department of Pediatrics, IWK Health Center, Canadian Centre for Vaccinology CCfV, Halifax, Canada; Laboratory of Immunity, Shantou University Medical College, Shantou, China; BioForge Canada Limited, Halifax, Canada., Dutt M; Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Canada; Department of Pediatrics, IWK Health Center, Canadian Centre for Vaccinology CCfV, Halifax, Canada; Laboratory of Immunity, Shantou University Medical College, Shantou, China; BioForge Canada Limited, Halifax, Canada., Dehury B; Department of Bioinformatics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal 576104, India., Martinez GS; Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Canada; Department of Pediatrics, IWK Health Center, Canadian Centre for Vaccinology CCfV, Halifax, Canada; Laboratory of Immunity, Shantou University Medical College, Shantou, China; BioForge Canada Limited, Halifax, Canada., Singh KP; Mahatma Jyotiba Phule Rohilkhand University, Bareilly, Uttar Pradesh, India., Kelvin DJ; Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Canada; Department of Pediatrics, IWK Health Center, Canadian Centre for Vaccinology CCfV, Halifax, Canada; Laboratory of Immunity, Shantou University Medical College, Shantou, China; BioForge Canada Limited, Halifax, Canada. Electronic address: david.kelvin@dal.ca.

Publikováno v: Journal of infection and public health [J Infect Public Health] 2024 Jul; Vol. 17 (7), pp. 102470. Date of Electronic Publication: 2024 Jun 07.

Identification of 3-Aryl-1-benzotriazole-1-yl-acrylonitrile as a Microtubule-Targeting Agent (MTA) in Solid Tumors.

Autor: Zoroddu S; Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy., Sanna L; Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy., Bordoni V; Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy., Weidong L; Division of Immunology, International Institute of Infection and Immunity, Shantou University Medical College, Shantou 515031, China., Gadau SD; Department of Veterinary Medicine, University of Sassari, 07100 Sassari, Italy., Carta A; Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy., Kelvin DJ; Division of Immunology, International Institute of Infection and Immunity, Shantou University Medical College, Shantou 515031, China.; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H 4R2, Canada., Bagella L; Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.; Sbarro Institute for Cancer Research and Molecular Medicine, Centre for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 May 24; Vol. 25 (11). Date of Electronic Publication: 2024 May 24.

PASC (Post Acute Sequelae of COVID-19) is associated with decreased neutralizing antibody titers in both biological sexes and increased ANG-2 and GM-CSF in females.

Autor: Jansen EB; Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, SK, Canada.; Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan, Saskatoon, SK, Canada., Ostadgavahi AT; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada., Hewins B; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada., Buchanan R; Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, SK, Canada., Thivierge BM; Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, SK, Canada., Sganzerla Martinez G; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada., Goncin U; Department of Anesthesiology, University of Saskatchewan, Saskatoon, SK, Canada., Francis ME; Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, SK, Canada.; Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan, Saskatoon, SK, Canada., Swan CL; Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, SK, Canada., Scruten E; Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, SK, Canada., Bell J; Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, SK, Canada.; Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan, Saskatoon, SK, Canada., Darbellay J; Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, SK, Canada., Facciuolo A; Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, SK, Canada.; Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK, Canada., Falzarano D; Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, SK, Canada.; Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK, Canada., Gerdts V; Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, SK, Canada.; Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK, Canada., Fenton ME; Division of Respirology, Critical Care, and Sleep Medicine, Department of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Hedlin P; Department of Anesthesiology, University of Saskatchewan, Saskatoon, SK, Canada., Kelvin DJ; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada., Kelvin AA; Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, SK, Canada. alyson.kelvin@usask.ca.

Publikováno v: Scientific reports [Sci Rep] 2024 Apr 29; Vol. 14 (1), pp. 9854. Date of Electronic Publication: 2024 Apr 29.

CDBProm: the Comprehensive Directory of Bacterial Promoters.

Autor: Martinez GS; Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada.; Pediatrics, Izaak Walton Killam (IWK) Health Center. Canadian Center for Vaccinology (CCfV), Halifax, Nova Scotia B3H 4H7, Canada.; BioForge Canada Limited, Halifax, Nova Scotia B3N 3B9, Canada., Perez-Rueda E; Instituto de Investigaciones en Matemáticas Aplicadas y en Sistemas, Universidad Nacional Autonóma de México, Unidad Académica del Estado de Yucatán, Mérida 97302, Yucatán, Mexico., Kumar A; Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada.; Pediatrics, Izaak Walton Killam (IWK) Health Center. Canadian Center for Vaccinology (CCfV), Halifax, Nova Scotia B3H 4H7, Canada.; BioForge Canada Limited, Halifax, Nova Scotia B3N 3B9, Canada., Dutt M; Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada.; Pediatrics, Izaak Walton Killam (IWK) Health Center. Canadian Center for Vaccinology (CCfV), Halifax, Nova Scotia B3H 4H7, Canada.; BioForge Canada Limited, Halifax, Nova Scotia B3N 3B9, Canada., Maya CR; Facultad de Ciencias e Ingeniería, Universidad Nacional Autonoma de Mexico, Mexico City 04510, Mexico., Ledesma-Dominguez L; Instituto de Investigaciones en Matematicas Aplicadas y en Sistemas, Universidad Nacional Autonoma de Mexico, Mexico City 04510, Mexico., Casa PL; Biotechnology Institute, Universidade de Caxias do Sul, Caxias do Sul, Rio Grande do Sul 95070-560, Brazil., Kumar A; Molecular Biology and Biotechnology, Tezpur University, Tezpur, Assam 784028, India., de Avila E Silva S; Biotechnology Institute, Universidade de Caxias do Sul, Caxias do Sul, Rio Grande do Sul 95070-560, Brazil., Kelvin DJ; Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada.; Pediatrics, Izaak Walton Killam (IWK) Health Center. Canadian Center for Vaccinology (CCfV), Halifax, Nova Scotia B3H 4H7, Canada.; BioForge Canada Limited, Halifax, Nova Scotia B3N 3B9, Canada.

Publikováno v: NAR genomics and bioinformatics [NAR Genom Bioinform] 2024 Feb 21; Vol. 6 (1), pp. lqae018. Date of Electronic Publication: 2024 Feb 21 (Print Publication: 2024).