Výsledky vyhledávání - "Dixan A. Benitez"

Akademický článek

p53 Genetics and Biology in Lung Carcinomas: Insights, Implications and Clinical Applications

Autor: Dixan A. Benitez, Guadalupe Cumplido-Laso, Marcos Olivera-Gómez, Nuria Del Valle-Del Pino, Alba Díaz-Pizarro, Sonia Mulero-Navarro, Angel Román-García, Jose Maria Carvajal-Gonzalez

Publikováno v: Biomedicines, Vol 12, Iss 7, p 1453 (2024)

The TP53 gene is renowned as a tumor suppressor, playing a pivotal role in overseeing the cell cycle, apoptosis, and maintaining genomic stability. Dysregulation of p53 often contributes to the initiation and progression of various cancers, including

Externí odkaz: https://doaj.org/article/ca37f5033ea947179f817b30af93d3b7

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Regulation of cell survival by resveratrol involves inhibition of NFκB-regulated gene expression in prostate cancer cells

Autor: Eulalia Pozo-Guisado, Marcela A. Hermoso, Dixan A. Benitez, Pedro M. Fernández-Salguero, Enrique A. Castellón

Publikováno v: The Prostate. 69:1045-1054

Background Polyphenols have been proposed as antitumoral agents. We have shown that resveratrol (RES) induced cell cycle arrest and promoted apoptosis in prostate cancer cells by inhibition of the PI3K pathway. The RES effects on NF kappaB activity i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daab091c81d6958db7057155720b7cad
https://doi.org/10.1002/pros.20953

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Genome-wide B1 retrotransposon binds the transcription factors dioxin receptor and Slug and regulates gene expression in vivo

Autor: Pedro M. Fernández-Salguero, Angel Carlos Roman, Dixan A. Benitez, Jose Maria Carvajal-Gonzalez

Publikováno v: Proceedings of the National Academy of Sciences. 105:1632-1637

Alterations in tissue-specific gene expression greatly affect cell function. Transcription factors (TFs) interact with cis -acting binding sites in noncoding enhancer promoter regions. Transposable elements (TEs) are abundant and similarly represente

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04af986e20386caac9f2d096402af26e
https://doi.org/10.1073/pnas.0708366105

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Non-genomic action of resveratrol on androgen and oestrogen receptors in prostate cancer: modulation of the phosphoinositide 3-kinase pathway

Autor: Pedro M. Fernández-Salguero, Marisa Clementi, Dixan A. Benitez, Eulalia Pozo-Guisado, Enrique A. Castellón

Publikováno v: British Journal of Cancer

Prostate cancer represents a major concern in human oncology and the phytoalexin resveratrol (RES) inhibits growth and proliferation of prostate cancer cells through the induction of apoptosis. In addition, previous data indicate that in oestrogen-re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f6edb5bf6749663c6802288d14d6da
http://europepmc.org/articles/PMC2359939

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Mechanisms Involved in Resveratrol-Induced Apoptosis and Cell Cycle Arrest in Prostate Cancer-Derived Cell Lines

Autor: Dixan A. Benitez, Alberto Álvarez-Barrientos, Pedro M. Fernández-Salguero, Eulalia Pozo-Guisado, Enrique A. Castellón

Publikováno v: Journal of Andrology. 28:282-293

Resveratrol is a polyphenol found at high concentrations in grapes and red wine with reported anticarcinogenic effects. We studied the molecular mechanism of resveratrol-induced apoptosis and proliferation arrest in prostate derived cells PZ-HPV-7 (n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9617bb7003e7b3c7632bf72dda69f7ae
https://doi.org/10.2164/jandrol.106.000968

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Effect of Leuprolide and Cetrorelix on Cell Growth, Apoptosis, and GnRH Receptor Expression in Primary Cell Cultures from Human Prostate Carcinoma

Autor: Marisa Clementi, Héctor R. Contreras, Catherine Sánchez, Dixan A. Benitez, Christian Huidobro, Leonardo Sáenz, Catalina Hitschfeld, Enrique A. Castellón

Publikováno v: CANCER INVESTIGATION
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

Contradictory data have been reported regarding the effect of GnRH agonists and antagonists on cell growth and survival, using prostate cancer-derived cell lines expressing either endogenous or exogenous GnRH receptors. We addressed the issue studyin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b83de35587b49ef0f9191b0a9ca9e78
https://doi.org/10.1080/07357900600629591

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Phosphatidylinositol 3-kinase interacts with the glucocorticoid receptor upon TLR2 activation

Autor: Gerald Zapata-Torres, Sergio Arancibia, John A. Cidlowski, Christine M. Jewell, María-Julieta González, Lucía Núñez, Patricia Langjahr, Enzo Candia, Marcela A. Hermoso, Dixan A. Benitez

Publikováno v: Journal of Cellular and Molecular Medicine
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

Airway inflammation is a common condition where glucocorticoids (GC) are a well-established therapy. It has been demonstrated that GC stimulate components of innate immunity. Specifically, GC up-regulate TLR2 expression and activation upon inflammato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9a9d040856e898d870c8d8ab6fe379
https://pubmed.ncbi.nlm.nih.gov/19874421

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Gonadotropin releasing hormone analogs induce apoptosis by extrinsic pathway involving p53 phosphorylation in primary cell cultures of human prostatic adenocarcinomas

Autor: Héctor R. Contreras, Christian Huidobro, Marisa Clementi, Cristian Acevedo, Catherine Sánchez, Juan Cabezas, Dixan A. Benitez, Enrique A. Castellón

Publikováno v: The Prostate. 69(10)

BACKGROUND Gonadotropin-releasing-hormone (GnRH) analogs are widely used to block hypothalamic–pituitary–gonadal axis and inhibit blood androgen levels in patients with prostate cancer (PCa). In addition, GnRH analogs induce proliferation arrest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a10e2769396c0f3f6156409bcb7366cc
https://pubmed.ncbi.nlm.nih.gov/19301301

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Effect of gnrh analogs on the expression of trka and p75 neurotrophin receptors in primary cell cultures from human prostate adenocarcinoma

Autor: Christian Huidobro, Dixan A. Benitez, Enrique A. Castellón, Catherine Sánchez, Marisa Clementi, Héctor R. Contreras

Publikováno v: PROSTATE
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

BACKGROUND GnRH analogs have antiproliferative and/or apoptotic effects on prostate cancer cells. Also, neurotrophin receptors TrkA and p75 have been reported in normal prostate suggesting a role in the gland growth control. In prostate cancer, TrkA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666af532222b0e443f7eb1ec26b69ffe

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