A Splicing-Independent Function of RBM10 Controls Specific 3′ UTR Processing to Regulate Cardiac Hypertrophy

Autor: Nimmy Mohan, Vikas Kumar, Divya T. Kandala, Chandrasekharan C. Kartha, Rakesh S. Laishram

Publikováno v: Cell Reports, Vol 24, Iss 13, Pp 3539-3553 (2018)

Summary: RNA binding motif protein 10 (RBM10) is a regulator of alternative splicing in apoptosis and inflammation. We discovered a splicing-independent function of RBM10 critical for the regulation of heart failure (HF). RBM10 is enriched in the hea

Externí odkaz: https://doaj.org/article/d565f06b98cf406a8f4695e9402c7f10

Targeting translation activity at the ribosome interface with UV-active small molecules

Autor: Divya T. Kandala, Massimiliano Clamer, Luca Minati, Alessia Del Piano

Publikováno v: ACS Omega
ACS Omega, Vol 4, Iss 6, Pp 10336-10345 (2019)

Puromycin is a well-known antibiotic that is used to study the mechanism of protein synthesis and to monitor translation efficiency due to its incorporation into nascent peptide chains. However, puromycin effects outside the ribo-some catalytic core

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b09350121ae5045bf22ec54d4a1a856a
https://doi.org/10.1101/436311

Active Ribosome Profiling with RiboLace

Autor: Paola Bernabò, Daniele Gubert, Alessandro Quattrone, Marta Marchioretto, Gabriella Viero, Graziano Guella, Elena Perenthaler, Massimiliano Clamer, Divya T. Kandala, Luca Minati, Thomas H. Gillingwater, Rodolfo F. Gómez-Biagi, Ewout J N Groen, Laura Pasquardini, Toma Tebaldi, Fabio Lauria

Publikováno v: Cell Reports, Vol 25, Iss 4, Pp 1097-1108.e5 (2018)
Clamer, M, Tebaldi, T, Lauria, F, Bernabò, P, Gomez-Biagi, R F, Marchioretto, M, Kandala, D T, Minati, L, Perenthaler, E, Gubert, D, Pasquardini, L, Guella, G, Groen, E, Gillingwater, T, Quattrone, A & Viero, G 2018, ' Active ribosome profiling with RiboLace ', Cell Reports, vol. 25, no. 4 . https://doi.org/10.1016/j.celrep.2018.09.084
Cell reports 25 (2018): 1097–1108.e5. doi:10.1016/j.celrep.2018.09.084
info:cnr-pdr/source/autori:Clamer M, Tebaldi T, Lauria F, Bernabò P, Gómez-Biagi RF, Marchioretto M, Kandala DT, Minati L, Perenthaler E, Gubert D, Pasquardini L, Guella G, Groen EJN, Gillingwater TH, Quattrone A, Viero G/titolo:Active Ribosome Profiling with RiboLace/doi:10.1016%2Fj.celrep.2018.09.084/rivista:Cell reports/anno:2018/pagina_da:1097/pagina_a:1108.e5/intervallo_pagine:1097–1108.e5/volume:25

Summary: Ribosome profiling, or Ribo-seq, is based on large-scale sequencing of RNA fragments protected from nuclease digestion by ribosomes. Thanks to its unique ability to provide positional information about ribosomes flowing along transcripts, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77bfbed0a47bd8044d49b0de8f3bb866
https://pubmed.ncbi.nlm.nih.gov/30355487