Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Divya S. Vinjamur"'
Autor:
Divya S. Vinjamur, Kristen J. Wade, Safa F. Mohamad, Jack L. Haar, Stephen T. Sawyer, Joyce A. Lloyd
Publikováno v:
Haematologica, Vol 99, Iss 10 (2014)
The Krüppel-like transcription factors KLF1 and KLF2 are essential for embryonic erythropoiesis. They can partially compensate for each other during mouse development, and coordinately regulate numerous erythroid genes, including the β-like globins
Externí odkaz:
https://doaj.org/article/e0656e8682134a0cac501bac088eda62
Autor:
Chunyan Ren, Scot A. Wolfe, Luca Pinello, Qiuming Yao, Jing Zeng, Mitchel A. Cole, Mir A. Hossain, Daniel E. Bauer, Kevin Luk, Connor McGuckin, Divya S. Vinjamur
Publikováno v:
Nature Genetics. 53:719-728
Known fetal hemoglobin (HbF) silencers have potential on-target liabilities for rational β-hemoglobinopathy therapeutic inhibition. Here, through transcription factor (TF) CRISPR screening, we identify zinc-finger protein (ZNF) 410 as an HbF repress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7833bcdbee82c68cac61773e5b8b2809
https://doi.org/10.1038/s41588-021-00843-w
https://doi.org/10.1038/s41588-021-00843-w
Autor:
Divya S Vinjamur, Yousef N Alhashem, Safa F Mohamad, Parth Amin, David C Williams, Joyce A Lloyd
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0146802 (2016)
In human adult erythroid cells, lower than normal levels of Krüppel-like transcription factor 1 (KLF1) are generally associated with decreased adult β- and increased fetal γ-globin gene expression. KLF1 also regulates BCL11A, a known repressor of
Externí odkaz:
https://doaj.org/article/d591f605cc294acbaad92a3bb23371cf
Autor:
Boya Liu, Christian Brendel, Divya S. Vinjamur, Yu Zhou, Chad Harris, Meaghan McGuinness, John P. Manis, Daniel E. Bauer, Haiming Xu, David A. Williams
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 30(8)
A promising treatment for β-hemoglobinopathies is the de-repression of γ-globin expression leading to increased fetal hemoglobin (HbF) by targeting BCL11A. Here, we aim to improve a lentivirus vector (LV) containing a single BCL11A shmiR (SS) to fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1688aa7998618d21c9424fcb776dd3c
https://pubmed.ncbi.nlm.nih.gov/35526095
https://pubmed.ncbi.nlm.nih.gov/35526095
Autor:
Wilfred F. J. van IJcken, Marja W. Wessels, Zakia Azmani, Steven Coyne, Sjaak Philipsen, Nynke Gillemans, Rutger W W Brouwer, Stella A. de Man, Kirsten van Lom, Ryo Kurita, Mirjam C G N van den Hout, Daniel E. Bauer, Marjon H. Cnossen, Divya S. Vinjamur, Thamar B. van Dijk, Yukio Nakamura, Rolph Pfundt, K L Juliëtte Schmidt
Publikováno v:
Blood Advances, 5, 9, pp. 2339-2349
Blood Adv
Blood Advances, 5, 2339-2349
Blood advances, 5(9), 2339-2349. American Society of Hematology
Blood Adv
Blood Advances, 5, 2339-2349
Blood advances, 5(9), 2339-2349. American Society of Hematology
The BCL11A gene encodes a transcriptional repressor with essential functions in multiple tissues during human development. Haploinsufficiency for BCL11A causes Dias-Logan syndrome (OMIM 617101), an intellectual developmental disorder with hereditary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2a63d43b032e913ad9abb5c17e571f
https://repository.ubn.ru.nl/handle/2066/233970
https://repository.ubn.ru.nl/handle/2066/233970
Autor:
Chunyan Ren, Daniel E. Bauer, Scot A. Wolfe, Luca Pinello, Qiuming Yao, Kevin Luk, Jing Zeng, Mitchel A. Cole, Mir A. Hossain, Connor McGuckin, Divya S. Vinjamur
Major effectors of adult-stage fetal globin silencing include the transcription factors (TFs) BCL11A and ZBTB7A/LRF and the NuRD chromatin complex, although each has potential on-target liabilities for rational β-hemoglobinopathy therapeutic inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25131e1282e02f6bb55ef079b20a4844
https://doi.org/10.1101/2020.08.31.272856
https://doi.org/10.1101/2020.08.31.272856
Publikováno v:
British Journal of Haematology. 180:630-643
The major β-haemoglobinopathies, sickle cell disease and β-thalassaemia, represent the most common monogenic disorders worldwide and a steadily increasing global disease burden. Allogeneic haematopoietic stem cell transplantation, the only curative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8702a3177dbf1ef4b3e640b65af13a93
https://doi.org/10.1111/bjh.15038
https://doi.org/10.1111/bjh.15038
Autor:
Connor McGuckin, Luca Pinello, Mir Hossain, Jing Zeng, Mitchel A. Cole, Chunyan Ren, Qiuming Yao, Divya S. Vinjamur, Daniel E. Bauer
Publikováno v:
Blood. 136:1-1
Several major effectors of adult-stage fetal globin silencing have been identified, including the transcription factors (TFs) BCL11A and ZBTB7A/LRF and the NuRD chromatin complex, although each has potential on-target liabilities for rational β-hemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64e21e51294cab91cbd7eef4abd6fab6
https://doi.org/10.1182/blood-2020-142134
https://doi.org/10.1182/blood-2020-142134
Autor:
Divya S. Vinjamur, Daniel E. Bauer, Donna Neuberg, Salmaan Karim, Connor McGuckin, Maren Pfirrmann, Alejandro Gutierrez, Kristen E. Stevenson, Joshua R. Sacher, Florence F. Wagner, Kimberly Stegmaier, James Degar, Laura Hinze
SUMMARYResistance to asparaginase, an antileukemic enzyme that depletes asparagine, is a common clinical problem. Using a genome-wide CRISPR/Cas9 screen, we found a synthetic lethal interaction between Wnt pathway activation and asparaginase in acute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d94b0c57d48e642f17d4c990de2b25ea
Autor:
Divya S, Vinjamur, Daniel E, Bauer
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1698
The recently established human umbilical cord blood-derived erythroid progenitor (HUDEP) cell lines have equipped red blood cell researchers with valuable in vitro models of erythroid development. Of the three established HUDEP cell lines, HUDEP-2 ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7f4c2ebbfde302fd206ac0c382174361
https://pubmed.ncbi.nlm.nih.gov/29076097
https://pubmed.ncbi.nlm.nih.gov/29076097