Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2

Autor: Kaustav Das Gupta, Melanie R. Shakespear, James E.B. Curson, Ambika M.V. Murthy, Abishek Iyer, Mark P. Hodson, Divya Ramnath, Vikas A. Tillu, Jessica B. von Pein, Robert C. Reid, Kathryn Tunny, Daniel M. Hohenhaus, Shayli Varasteh Moradi, Gregory M. Kelly, Takumi Kobayashi, Jennifer H. Gunter, Alexander J. Stevenson, Weijun Xu, Lin Luo, Alun Jones, Wayne A. Johnston, Antje Blumenthal, Kirill Alexandrov, Brett M. Collins, Jennifer L. Stow, David P. Fairlie, Matthew J. Sweet

Publikováno v: Cell Reports, Vol 30, Iss 8, Pp 2712-2728.e8 (2020)

Summary: Histone deacetylases (HDACs) drive innate immune cell-mediated inflammation. Here we identify class IIa HDACs as key molecular links between Toll-like receptor (TLR)-inducible aerobic glycolysis and macrophage inflammatory responses. A prote

Externí odkaz: https://doaj.org/article/499080960e35403c84db1073e30bdd67

HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophages

Autor: Kaustav Das Gupta, Divya Ramnath, Jessica B. von Pein, James E. B. Curson, Yizhuo Wang, Rishika Abrol, Asha Kakkanat, Shayli Varasteh Moradi, Kimberley S. Gunther, Ambika M. V. Murthy, Claudia J. Stocks, Ronan Kapetanovic, Robert C. Reid, Abishek Iyer, Zoe C. Ilka, William M. Nauseef, Manuel Plan, Lin Luo, Jennifer L. Stow, Kate Schroder, Denuja Karunakaran, Kirill Alexandrov, Melanie R. Shakespear, Mark A. Schembri, David P. Fairlie, Matthew J. Sweet

Publikováno v: Proceedings of the National Academy of Sciences. 120

The immune system must be able to respond to a myriad of different threats, each requiring a distinct type of response. Here, we demonstrate that the cytoplasmic lysine deacetylase HDAC7 in macrophages is a metabolic switch that triages danger signal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ae48c48ad507d8f01ac2dd159d35738
https://doi.org/10.1073/pnas.2212813120

Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease

Autor: Céline Jouffe, Benjamin D. Weger, Eva Martin, Florian Atger, Meltem Weger, Cédric Gobet, Divya Ramnath, Aline Charpagne, Delphine Morin-Rivron, Elizabeth E. Powell, Matthew J. Sweet, Mojgan Masoodi, N. Henriette Uhlenhaut, Frédéric Gachon

Publikováno v: Jouffe, Céline; Weger, Benjamin D; Martin, Eva; Atger, Florian; Weger, Meltem; Gobet, Cédric; Ramnath, Divya; Charpagne, Aline; Morin-Rivron, Delphine; Powell, Elizabeth E; Sweet, Matthew J; Masoodi, Mojgan; Uhlenhaut, N Henriette; Gachon, Frédéric (2022). Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease. Proceedings of the National Academy of Sciences of the United States of America-PNAS, 119(10), e2200083119. National Academy of Sciences NAS 10.1073/pnas.2200083119
Proc. Natl. Acad. Sci. U.S.A. 119:e2200083119 (2022)

Significance While increasing evidence associates the disruption of circadian rhythms with pathologic conditions, including obesity, type 2 diabetes, and nonalcoholic fatty liver diseases (NAFLD), the involved mechanisms are still poorly described. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd824578f563e912c709879f9167c0f8
https://boris.unibe.ch/166573/1/pnas.2200083119.pdf

Inhibitors of class I histone deacetylases attenuate thioacetamide‐induced liver fibrosis in mice by suppressing hepatic type 2 inflammation

Autor: Matthew J. Sweet, Abishek Iyer, David P. Fairlie, Elizabeth E. Powell, Zhixuan Loh, Robert Reid, Rebecca L. Fitzsimmons, Divya Ramnath, Jennifer L. Stow, Kate Schroder, Katharine M. Irvine, Andrew D. Clouston, Praveer Gupta

Publikováno v: Br J Pharmacol

BACKGROUND AND PURPOSE: Chronic liver diseases feature excessive collagen and matrix protein deposition or crosslinking that characterises fibrosis, leads to scar tissue, and disrupts liver functions. There is no effective treatment. This study inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d4b054426fc7b7b0d7a3c5c6a70221
https://doi.org/10.1111/bph.14768

Hyaluronan synthase 2–mediated hyaluronan production mediates Notch1 activation and liver fibrosis

Autor: Matthew J. Sweet, Paul W. Noble, Nan Deng, Daniel Shouhed, Yoon Seok Roh, So Yeon Kim, Koichiro Ohashi, Mazen Noureddin, I-Fang Hsin, Dianhua Jiang, Shelly C. Lu, Cheng Liu, Elizabeth E. Powell, Edward Mena, Ekihiro Seki, Divya Ramnath, Zhenqiu Liu, Yoon Mee Yang, Robert F. Schwabe, Jiurong Liang

Publikováno v: Science translational medicine, vol 11, iss 496

Hyaluronan (HA), a major extracellular matrix glycosaminoglycan, is a biomarker for cirrhosis. However, little is known about the regulatory and downstream mechanisms of HA overproduction in liver fibrosis. Hepatic HA and HA synthase 2 (HAS2) express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150253e1d107be75a5ce1900fd54ca05
https://europepmc.org/articles/PMC6589184/