Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Divya Nagarajan"'
Autor:
Irineos Papakyriacou, Ginte Kutkaite, Marta Rúbies Bedós, Divya Nagarajan, Liam P. Alford, Michael P. Menden, Yumeng Mao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Immune checkpoint blockade therapy aims to activate the immune system to eliminate cancer cells. However, clinical benefits are only recorded in a subset of patients. Here, we leverage genome-wide CRISPR/Cas9 screens in a Tumor-Immune co-Cul
Externí odkaz:
https://doaj.org/article/b4b21ac099f0476298aa50b1eda1257e
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/b47533c8b4fe4e579e725f539517f9b5
Autor:
Gürcan Tunalı, Marta Rúbies Bedós, Divya Nagarajan, Patrik Fridh, Irineos Papakyriacou, Yumeng Mao
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 7 (2023)
Inflammatory mediators released by cancer cells promote the induction of immune suppression and tolerance in myeloid cells. IL-1 receptor–associated kinase-3 (IRAK3) is a pseudokinase that inhibits IL-1/TLR signaling, but its role in patients treat
Externí odkaz:
https://doaj.org/article/051fd3097dde4c799d18a39953014f50
Autor:
Rukaia Almshayakhchi, Divya Nagarajan, Jayakumar Vadakekolathu, Barbara-Ann Guinn, Stephen Reeder, Victoria Brentville, Rachael Metheringham, A. Graham Pockley, Lindy Durrant, Stephanie McArdle
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Many cancers, including myeloid leukaemia express the cancer testis antigen (CTA) DDX43 (HAGE) and/or the oncogene Wilms’ tumour (WT1). Here we demonstrate that HAGE/WT1-ImmunoBody® vaccines derived T-cells can kill ex-vivo human CML cell lines ex
Externí odkaz:
https://doaj.org/article/f437f782c2b54899806b100305362a57
Autor:
Cydni N. Williams, Cindy T. McEvoy, Miranda M. Lim, Steven A. Shea, Vivek Kumar, Divya Nagarajan, Kurt Drury, Natalia Rich-Wimmer, Trevor A. Hall
Publikováno v:
Children, Vol 9, Iss 5, p 748 (2022)
Over 50,000 children are hospitalized annually for traumatic brain injury (TBI) and face long-term cognitive morbidity. Over 50% develop sleep/wake disturbances (SWDs) that can affect brain development and healing. We hypothesized SWDs would portend
Externí odkaz:
https://doaj.org/article/6cb538dfb25a4651a3ee9c6a46f07716
Autor:
Stefania Cuzzubbo, Sara Mangsbo, Divya Nagarajan, Kinana Habra, Alan Graham Pockley, Stephanie E. B. McArdle
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Although the discovery and characterization of multiple tumor antigens have sparked the development of many antigen/derived cancer vaccines, many are poorly immunogenic and thus, lack clinical efficacy. Adjuvants are therefore incorporated into vacci
Externí odkaz:
https://doaj.org/article/ab751ec711c943a4a2c36f31730dcf02
Autor:
Gemma A. Foulds, Jayakumar Vadakekolathu, Tarek M. A. Abdel-Fatah, Divya Nagarajan, Stephen Reeder, Catherine Johnson, Simon Hood, Paul M. Moseley, Stephen Y. T. Chan, A. Graham Pockley, Sergio Rutella, Stephanie E. B. McArdle
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Background: Interactions between the immune system and tumors are highly reciprocal in nature, leading to speculation that tumor recurrence or therapeutic resistance could be influenced or predicted by immune events that manifest locally, but can be
Externí odkaz:
https://doaj.org/article/ff8ec7bc8e834c0b9816a47eb4669bf7
Publikováno v:
Biomedicines, Vol 6, Iss 1, p 20 (2018)
Breast cancer is a very heterogeneous disease, both at a molecular and a histological level. Five intrinsic subtypes were initially identified—Luminal-A, Luminal-B, HER2+, Triple negative/basal like (TNBC) and normal like—subsequently expanded to
Externí odkaz:
https://doaj.org/article/d1266d2238654928814d7f33c893073f
Publikováno v:
Edelweiss Journal of Food Science and Technology. :38-44
Respondents evaluated combinations of messages about the emerging technology of cultured meat, these messages created to be meaningful to a non-technical person, and dealing with the sensory, technical, and sociological aspects of cultured meat. The
Publikováno v:
Critical Care Medicine. 51:319-319