Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Divya M Chari"'
Autor:
Jacqueline A Tickle, Jon Sen, Christopher Adams, David N Furness, Rupert Price, Viswapathi Kandula, Nikolaos Tzerakis, Divya M Chari
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 5, Pp 1057-1061 (2023)
The use of live animal models for testing new therapies for brain and spinal cord repair is a controversial area. Live animal models have associated ethical issues and scientific concerns regarding the predictability of human responses. Alternative m
Externí odkaz:
https://doaj.org/article/fc1c757151c443d69fc5c2e6bdcffe83
Autor:
Jon Prager, Christopher F Adams, Alexander M Delaney, Guillaume Chanoit, John F Tarlton, Liang-Fong Wong, Divya M Chari, Nicolas Granger
Publikováno v:
Journal of Tissue Engineering, Vol 11 (2020)
Safe hydrogel delivery requires stiffness-matching with host tissues to avoid iatrogenic damage and reduce inflammatory reactions. Hydrogel-encapsulated cell delivery is a promising combinatorial approach to spinal cord injury therapy, but a lack of
Externí odkaz:
https://doaj.org/article/57d932e453c24d1698b3acc787315df9
Publikováno v:
Materials; Volume 16; Issue 1; Pages: 124
Spinal cord injury is debilitating with functional loss often permanent due to a lack of neuro-regenerative or neuro-therapeutic strategies. A promising approach to enhance biological function is through implantation of tissue engineered constructs,
Publikováno v:
Journal of Functional Biomaterials, Vol 6, Iss 2, Pp 259-276 (2015)
Genetically engineered neural stem cell (NSC) transplants offer a key strategy to augment neural repair by releasing therapeutic biomolecules into injury sites. Genetic modification of NSCs is heavily reliant on viral vectors but cytotoxic effects ha
Externí odkaz:
https://doaj.org/article/e0aa69e4dfa743108b95dbddefe533b6
Autor:
Sarah R. Hart, Divya M. Chari, Christopher F. Adams, Richard D. Emes, Sarah Harris, Nikolaos Tzerakis, Georgios Solomou, Louise Finch, Jon Sen, Catherine S. Lane
Publikováno v:
Journal of Controlled Release. 321:553-563
High transplant cell loss is a major barrier to translation of stem cell therapy for pathologies of the brain and spinal cord. Encapsulated delivery of stem cells in biomaterials for cell therapy is gaining popularity but experimental research has ov
Autor:
Divya M. Chari, Mark R. Pickard
Publikováno v:
International Journal of Molecular Sciences, Vol 11, Iss 3, Pp 967-981 (2010)
Magnetic nanoparticles (MNPs) are important contrast agents used to monitor a range of neuropathological processes; microglial cells significantly contribute to MNP uptake in sites of pathology. Microglial activation occurs following most CNS patholo
Externí odkaz:
https://doaj.org/article/328c451f23714cb3bfcd1e5765b2bee7
Autor:
Farhana Chowdhury, William Aidan Woods, Christopher F. Adams, Divya M. Chari, Nikolaos Tzerakis
Publikováno v:
Advanced NanoBiomed Research, Vol 1, Iss 9, Pp n/a-n/a (2021)
Neural precursor/stem cell transplantation therapies promote regeneration in neurological injuries, but current cell delivery methods have drawbacks. These include risks with surgical microinjection (e.g., hemorrhage, embolism) and high cell loss wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20936767e04ca3524d2d96e3c6c9f94e
https://eprints.keele.ac.uk/9762/1/anbr.202100051.pdf
https://eprints.keele.ac.uk/9762/1/anbr.202100051.pdf
518 New In Vitro Model of Traumatic Brain Injury to Assess Biomaterial Based Regenerative Strategies
Publikováno v:
British Journal of Surgery. 108
Introduction Penetrating traumatic brain injury (pTBI) management is largely supportive, with no clinically established regenerative therapies. Neurocompatible biomaterials offer a high potential to promote regenerative mechanisms but facile, high th
Autor:
Jacqueline A. Tickle, Divya M. Chari
Publikováno v:
Journal of Tissue Engineering and Regenerative Medicine. 13:1732-1737
Genetic engineering of cell transplant populations offers potential for delivery of neurotherapeutic factors to modify the regenerative microenvironment of the injured spinal cord. The use of magnetic nanoparticle (MNP) based vectors has reduced the
Protected delivery of neural stem cells (NSCs; a major transplant population) within bioscaffolds has the potential to improve regenerative outcomes in sites of spinal cord injury. Emergent research has indicated clinical grade bioscaffolds (e.g. tho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf7184219ad7c4f5fd35234d1b5796d
https://eprints.keele.ac.uk/9223/1/Hemopatch_6thJan2021_manuscript-unhighlighted.doc
https://eprints.keele.ac.uk/9223/1/Hemopatch_6thJan2021_manuscript-unhighlighted.doc