Mass Spectrometry Profiling of Pituitary Glands

Autor: Paul C. Guest, Hassan Rahmoune, Divya Krishnamurthy

Publikováno v: Methods in Molecular Biology ISBN: 9781493976133

Many chronic diseases are associated with hypothalamic-pituitary-adrenal axis dysfunction. Therefore, proteomic profiling of the pituitary gland has potential to uncover new information on the underlying pathways affected in these conditions. This co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1784765d168dcc36c4145a985219de57
https://doi.org/10.1007/978-1-4939-7614-0_31

Proteomic Profiling of the Pituitary Gland in Studies of Psychiatric Disorders

Autor: Divya, Krishnamurthy, Hassan, Rahmoune, Paul C, Guest

Publikováno v: Advances in experimental medicine and biology. 974

Psychiatric disorders have been associated with perturbations of the hypothalamic-pituitary-adrenal axis. Therefore, proteomic studies of the pituitary gland have the potential to provide new insights into the underlying pathways affected in these co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::13a1dc29cc6a86866ac97f9d54a97858
https://pubmed.ncbi.nlm.nih.gov/28353251

Development of an Assay for Measuring Proprotein-Conversion Activity on a Multiplex Magnetic Bead-Based Array Platform

Autor: Paul C. Guest, Divya Krishnamurthy, Hassan Rahmoune

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9783319524788

This chapter describes a protocol for measuring prolyl oligopeptidase (POP) activity using a biotinylated peptide substrate coupled to magnetic microspheres. The complex is incubated in the presence of a pituitary extract and activity can be detected

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51845d78a1f16916b560f3097f6097e2
https://doi.org/10.1007/978-3-319-52479-5_31

Metabolic, hormonal and stress-related molecular changes in post-mortem pituitary glands from schizophrenia subjects

Autor: Hassan Rahmoune, F. Markus Leweke, Paul C. Guest, Sandra Pietsch, Yishai Levin, Natacha Vanattou-Saifoudine, Theodoros A. Koutroukides, Divya Krishnamurthy, Laura W. Harris, Sabine Bahn

Publikováno v: The World Journal of Biological Psychiatry; Vol 14
The World Journal of Biological Psychiatry
World Journal of Biological Psychiatry, 14(7), 478-489. Taylor & Francis Ltd

Objectives. To identify a molecular profile for schizophrenia using post-mortem pituitaries from schizophrenia and control subjects. Methods. Molecular profiling analysis of pituitaries from schizophrenia (n = 14) and control (n = 15) subjects was ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df461428cb00edb283ac61d50786382f

Discovery of a Novel Series of Inhibitors of Lymphoid Tyrosine Phosphatase with Activity in Human T Cells

Autor: Sheng Li, Zhong Yin Zhang, Andrew C. Chan, Matthew D. Falk, Nunzio Bottini, Rossella Messina, Stephanie M. Stanford, Divya Krishnamurthy, Xiao Yu, Yantao He, Russell Dahl, Roza Kazemi, Virgil L. Woods, Bikash Debnath, Nouri Neamati, Amy M. Barrios, Tong Liu

Publikováno v: Journal of Medicinal Chemistry. 54:1640-1654

The lymphoid tyrosine phosphatase LYP, encoded by the PTPN22 gene, is a critical regulator of signaling in T cells and recently emerged as a candidate target for therapy of autoimmune diseases. Here, by library screening, we identified a series of no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad928fc7c63aa08b1e512b8a8e73110a
https://doi.org/10.1021/jm101202j