Patient-derived tumor organoids: a new avenue for preclinical research and precision medicine in oncology.

Autor: Thorel L; INSERM U1086 ANTICIPE (Interdisciplinary Research Unit for Cancers Prevention and Treatment), BioTICLA Laboratory (Precision Medicine for Ovarian Cancers), Université de Caen Normandie, Caen, France.; Comprehensive Cancer Center François Baclesse, UNICANCER, Caen, France., Perréard M; INSERM U1086 ANTICIPE (Interdisciplinary Research Unit for Cancers Prevention and Treatment), BioTICLA Laboratory (Precision Medicine for Ovarian Cancers), Université de Caen Normandie, Caen, France.; Department of Head and Neck Surgery, Caen University Hospital, Caen, France., Florent R; ORGAPRED core facility, US PLATON, Université de Caen Normandie, Caen, France., Divoux J; INSERM U1086 ANTICIPE (Interdisciplinary Research Unit for Cancers Prevention and Treatment), BioTICLA Laboratory (Precision Medicine for Ovarian Cancers), Université de Caen Normandie, Caen, France.; Comprehensive Cancer Center François Baclesse, UNICANCER, Caen, France.; ORGAPRED core facility, US PLATON, Université de Caen Normandie, Caen, France., Coffy S; Biomics, CEA, Inserm, IRIG, UA13 BGE, Univ. Grenoble Alpes, Grenoble, France., Vincent A; CNRS UMR9020, INSERM U1277, CANTHER Cancer Heterogeneity Plasticity and Resistance to Therapies, Univ. Lille, CNRS, Inserm, CHU Lille, Lille, France., Gaggioli C; CNRS UMR7284, INSERM U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), 3D-Hub-S Facility, CNRS University Côte d'Azur, Nice, France., Guasch G; CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Epithelial Stem Cells and Cancer Team, Aix-Marseille University, Marseille, France., Gidrol X; Biomics, CEA, Inserm, IRIG, UA13 BGE, Univ. Grenoble Alpes, Grenoble, France., Weiswald LB; INSERM U1086 ANTICIPE (Interdisciplinary Research Unit for Cancers Prevention and Treatment), BioTICLA Laboratory (Precision Medicine for Ovarian Cancers), Université de Caen Normandie, Caen, France. lb.weiswald@baclesse.unicancer.fr.; Comprehensive Cancer Center François Baclesse, UNICANCER, Caen, France. lb.weiswald@baclesse.unicancer.fr.; ORGAPRED core facility, US PLATON, Université de Caen Normandie, Caen, France. lb.weiswald@baclesse.unicancer.fr., Poulain L; INSERM U1086 ANTICIPE (Interdisciplinary Research Unit for Cancers Prevention and Treatment), BioTICLA Laboratory (Precision Medicine for Ovarian Cancers), Université de Caen Normandie, Caen, France. l.poulain@baclesse.unicancer.fr.; Comprehensive Cancer Center François Baclesse, UNICANCER, Caen, France. l.poulain@baclesse.unicancer.fr.; ORGAPRED core facility, US PLATON, Université de Caen Normandie, Caen, France. l.poulain@baclesse.unicancer.fr.

Publikováno v: Experimental & molecular medicine [Exp Mol Med] 2024 Jul; Vol. 56 (7), pp. 1531-1551. Date of Electronic Publication: 2024 Jul 01.

The TRIPLEX study: use of patient-derived tumor organoids as an innovative tool for precision medicine in triple-negative breast cancer.

Autor: Divoux J; INSERM U1086 ANTICIPE (Interdisciplinary Research Unit for Cancers Prevention and Treatment), BioTICLA Laboratory (Precision Medicine for Ovarian Cancers), Université de Caen Normandie, Caen, France.; Comprehensive Cancer Center François Baclesse, UNICANCER, Caen, France.; US PLATON, ORGAPRED Core Facility, Université de Caen Normandie, Caen, France., Florent R; INSERM U1086 ANTICIPE (Interdisciplinary Research Unit for Cancers Prevention and Treatment), BioTICLA Laboratory (Precision Medicine for Ovarian Cancers), Université de Caen Normandie, Caen, France.; Comprehensive Cancer Center François Baclesse, UNICANCER, Caen, France.; US PLATON, ORGAPRED Core Facility, Université de Caen Normandie, Caen, France., Jacobs M; Comprehensive Cancer Center François Baclesse, Breast Cancer Unit, UNICANCER, Institut Normand du Sein, Caen, France., Lequesne J; Comprehensive Cancer Center François Baclesse, Clinical Research Department, UNICANCER, Caen, France., Grellard JM; Comprehensive Cancer Center François Baclesse, Clinical Research Department, UNICANCER, Caen, France., San C; Comprehensive Cancer Center François Baclesse, Clinical Research Department, UNICANCER, Caen, France., Grossi S; Comprehensive Cancer Center François Baclesse, Clinical Research Department, UNICANCER, Caen, France., Kerdja K; Comprehensive Cancer Center François Baclesse, Clinical Research Department, UNICANCER, Caen, France., Clarisse B; Comprehensive Cancer Center François Baclesse, Clinical Research Department, UNICANCER, Caen, France., Boudier G; Comprehensive Cancer Center François Baclesse, Clinical Research Department, UNICANCER, Caen, France., Cherifi F; Comprehensive Cancer Center François Baclesse, Breast Cancer Unit, UNICANCER, Institut Normand du Sein, Caen, France., Briand M; INSERM U1086 ANTICIPE (Interdisciplinary Research Unit for Cancers Prevention and Treatment), BioTICLA Laboratory (Precision Medicine for Ovarian Cancers), Université de Caen Normandie, Caen, France.; US PLATON, Biological Resource Center 'OvaRessources', Université de Caen Normandie, Caen, France., Dolivet E; INSERM U1086 ANTICIPE (Interdisciplinary Research Unit for Cancers Prevention and Treatment), BioTICLA Laboratory (Precision Medicine for Ovarian Cancers), Université de Caen Normandie, Caen, France.; Comprehensive Cancer Center François Baclesse, Department of Surgery, UNICANCER, Caen, France., Johnson A; Comprehensive Cancer Center François Baclesse, Breast Cancer Unit, UNICANCER, Institut Normand du Sein, Caen, France.; Comprehensive Cancer Center François Baclesse, Clinical Research Department, UNICANCER, Caen, France., Dubois B; Comprehensive Cancer Center François Baclesse, North-West Canceropole Data Center, UNICANCER, Caen, France., Harter V; Comprehensive Cancer Center François Baclesse, North-West Canceropole Data Center, UNICANCER, Caen, France., Lacroix J; Comprehensive Cancer Center François Baclesse, Department of Radiology, UNICANCER, Caen, France., Raboutet C; Comprehensive Cancer Center François Baclesse, Department of Radiology, UNICANCER, Caen, France., Marie B; Comprehensive Cancer Center François Baclesse, Department of Radiology, UNICANCER, Caen, France., Rousseau N; Comprehensive Cancer Center François Baclesse, UNICANCER, Caen, France.; Biological Resource Center 'Tumorotheque de Caen Basse-Normandie', IRCBN Institut Régional du Cancer Basse Normandie, Caen, France., Blanc-Fournier C; INSERM U1086 ANTICIPE (Interdisciplinary Research Unit for Cancers Prevention and Treatment), BioTICLA Laboratory (Precision Medicine for Ovarian Cancers), Université de Caen Normandie, Caen, France.; US PLATON, Biological Resource Center 'OvaRessources', Université de Caen Normandie, Caen, France.; Biological Resource Center 'Tumorotheque de Caen Basse-Normandie', IRCBN Institut Régional du Cancer Basse Normandie, Caen, France.; Comprehensive Cancer Center François Baclesse, Department of Biopathology, UNICANCER, Caen, France., Vaur D; Comprehensive Cancer Center François Baclesse, Department of Cancer Biology and Genetics, UNICANCER, Caen, France., Figeac M; CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US 41 - UAR 2014 - PLBS, University of Lille, Lille, France., Poulain L; INSERM U1086 ANTICIPE (Interdisciplinary Research Unit for Cancers Prevention and Treatment), BioTICLA Laboratory (Precision Medicine for Ovarian Cancers), Université de Caen Normandie, Caen, France.; US PLATON, ORGAPRED Core Facility, Université de Caen Normandie, Caen, France.; US PLATON, Biological Resource Center 'OvaRessources', Université de Caen Normandie, Caen, France., Weiswald LB; INSERM U1086 ANTICIPE (Interdisciplinary Research Unit for Cancers Prevention and Treatment), BioTICLA Laboratory (Precision Medicine for Ovarian Cancers), Université de Caen Normandie, Caen, France. lb.weiswald@baclesse.unicancer.fr.; Comprehensive Cancer Center François Baclesse, UNICANCER, Caen, France. lb.weiswald@baclesse.unicancer.fr.; US PLATON, ORGAPRED Core Facility, Université de Caen Normandie, Caen, France. lb.weiswald@baclesse.unicancer.fr.; INSERM U1086 ANTICIPE (Interdisciplinary Research Unit for Cancers Prevention and Treatment), Comprehensive Cancer Center François Baclesse, 3 Avenue du Général Harris, BP 45026, Caen Cedex 05, 14 076, France. lb.weiswald@baclesse.unicancer.fr., Emile G; Comprehensive Cancer Center François Baclesse, Breast Cancer Unit, UNICANCER, Institut Normand du Sein, Caen, France. g.emile@baclesse.unicancer.fr.; Comprehensive Cancer Center François Baclesse, Clinical Research Department, UNICANCER, Caen, France. g.emile@baclesse.unicancer.fr.; Breast Cancer Unit, Comprehensive Cancer Center François Baclesse, 3 Avenue du Général Harris, BP 45026, Caen Cedex 05, 14 076, France. g.emile@baclesse.unicancer.fr.

Publikováno v: BMC cancer [BMC Cancer] 2023 Sep 19; Vol. 23 (1), pp. 883. Date of Electronic Publication: 2023 Sep 19.

ORGAVADS: establishment of tumor organoids from head and neck squamous cell carcinoma to assess their response to innovative therapies.

Autor: Perréard M; Normandy University, UNICAEN, INSERM U1086 ANTICIPE (Interdisciplinary Research Unit for Cancers Prevention and Treatment), BioTICLA laboratory (Precision medicine for ovarian cancers), Comprehensive Cancer Center François Baclesse, 3 Avenue du Général Harris, BP 45026, 14 076, Caen, Cedex 05, France.; UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France.; Department of Head and Neck Surgery, Caen University Hospital, Caen, France., Florent R; Normandy University, UNICAEN, INSERM U1086 ANTICIPE (Interdisciplinary Research Unit for Cancers Prevention and Treatment), BioTICLA laboratory (Precision medicine for ovarian cancers), Comprehensive Cancer Center François Baclesse, 3 Avenue du Général Harris, BP 45026, 14 076, Caen, Cedex 05, France.; UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France.; Normandy University, UNICAEN, SF Normandy Oncology, US PLATON, ORGAPRED core facility, Caen, France., Divoux J; Normandy University, UNICAEN, INSERM U1086 ANTICIPE (Interdisciplinary Research Unit for Cancers Prevention and Treatment), BioTICLA laboratory (Precision medicine for ovarian cancers), Comprehensive Cancer Center François Baclesse, 3 Avenue du Général Harris, BP 45026, 14 076, Caen, Cedex 05, France.; UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France.; Normandy University, UNICAEN, SF Normandy Oncology, US PLATON, ORGAPRED core facility, Caen, France., Grellard JM; UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France.; Clinical Research Department, UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France., Lequesne J; UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France.; Clinical Research Department, UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France., Briand M; Normandy University, UNICAEN, INSERM U1086 ANTICIPE (Interdisciplinary Research Unit for Cancers Prevention and Treatment), BioTICLA laboratory (Precision medicine for ovarian cancers), Comprehensive Cancer Center François Baclesse, 3 Avenue du Général Harris, BP 45026, 14 076, Caen, Cedex 05, France.; UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France.; UNICANCER, Comprehensive Cancer Center François Baclesse, Biological Resource Center 'OvaRessources', Caen, France., Clarisse B; UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France.; Clinical Research Department, UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France., Rousseau N; UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France.; IRCBN Institut Régional du cancer Basse Normandie, Biological Resource Center 'Tumorotheque de Caen Basse-Normandie', Caen, France., Lebreton E; Clinical Research Department, Caen University Hospital, Caen, France., Dubois B; UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France.; UNICANCER, Comprehensive Cancer Center François Baclesse, North-West Canceropole Data Center, Caen, France., Harter V; UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France.; UNICANCER, Comprehensive Cancer Center François Baclesse, North-West Canceropole Data Center, Caen, France., Lasne-Cardon A; UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France.; Department of Head and Neck Surgery, UNICANCER, Comprehensive Cancer Center François Baclesse, 3 avenue du Général Harris, Caen, 14000, France., Drouet J; UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France.; Department of Oral and Maxillofacial Surgery, UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France., Johnson A; UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France.; Department of Medical Oncology Surgery, UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France., Le Page AL; Department of Pathology, Caen University Hospital, Caen, France., Bazille C; Department of Pathology, Caen University Hospital, Caen, France., Jeanne C; UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France.; Department of Biopathology, UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France., Figeac M; University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US 41 - UAR 2014 - PLBS, Lille, France., Goardon N; UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France.; Department of Cancer Biology and Genetics, UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France., Vaur D; UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France.; Department of Cancer Biology and Genetics, UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France., Micault E; Department of Head and Neck Surgery, Caen University Hospital, Caen, France., Humbert M; Department of Head and Neck Surgery, Caen University Hospital, Caen, France., Thariat J; UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France.; LPC Caen ENSICAEN/CNRS UMR6534, Caen, France., Babin E; Normandy University, UNICAEN, INSERM U1086 ANTICIPE (Interdisciplinary Research Unit for Cancers Prevention and Treatment), BioTICLA laboratory (Precision medicine for ovarian cancers), Comprehensive Cancer Center François Baclesse, 3 Avenue du Général Harris, BP 45026, 14 076, Caen, Cedex 05, France.; Department of Head and Neck Surgery, Caen University Hospital, Caen, France., Poulain L; Normandy University, UNICAEN, INSERM U1086 ANTICIPE (Interdisciplinary Research Unit for Cancers Prevention and Treatment), BioTICLA laboratory (Precision medicine for ovarian cancers), Comprehensive Cancer Center François Baclesse, 3 Avenue du Général Harris, BP 45026, 14 076, Caen, Cedex 05, France.; UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France.; Normandy University, UNICAEN, SF Normandy Oncology, US PLATON, ORGAPRED core facility, Caen, France., Weiswald LB; Normandy University, UNICAEN, INSERM U1086 ANTICIPE (Interdisciplinary Research Unit for Cancers Prevention and Treatment), BioTICLA laboratory (Precision medicine for ovarian cancers), Comprehensive Cancer Center François Baclesse, 3 Avenue du Général Harris, BP 45026, 14 076, Caen, Cedex 05, France. lb.weiswald@baclesse.unicancer.fr.; UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France. lb.weiswald@baclesse.unicancer.fr.; Normandy University, UNICAEN, SF Normandy Oncology, US PLATON, ORGAPRED core facility, Caen, France. lb.weiswald@baclesse.unicancer.fr., Bastit V; UNICANCER, Comprehensive Cancer Center François Baclesse, Caen, France. bastit-v@chu-caen.fr.; Department of Head and Neck Surgery, UNICANCER, Comprehensive Cancer Center François Baclesse, 3 avenue du Général Harris, Caen, 14000, France. bastit-v@chu-caen.fr.

Publikováno v: BMC cancer [BMC Cancer] 2023 Mar 09; Vol. 23 (1), pp. 223. Date of Electronic Publication: 2023 Mar 09.

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Deletion of intestinal epithelial AMP-activated protein kinase alters distal colon permeability but not glucose homeostasis.

Autor: Olivier S; Université de Paris, Institut Cochin, INSERM, CNRS, F-75014 Paris, France., Pochard C; University of Nantes, INSERM, TENS, The Enteric Nervous System in Gut and Brain Diseases, IMAD, Nantes, France., Diounou H; Université de Paris, Institut Cochin, INSERM, CNRS, F-75014 Paris, France., Castillo V; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA., Divoux J; Sorbonne Université, INSERM, CNRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI), Paris, France., Alcantara J; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA., Leclerc J; Université de Paris, Institut Cochin, INSERM, CNRS, F-75014 Paris, France., Guilmeau S; Université de Paris, Institut Cochin, INSERM, CNRS, F-75014 Paris, France., Huet C; Université de Paris, Institut Cochin, INSERM, CNRS, F-75014 Paris, France., Charifi W; Université de Paris, Institut Cochin, INSERM, CNRS, F-75014 Paris, France., Varin TV; Québec Heart and Lung Research Institute (IUCPQ) & Institute for Nutrition and Functional Foods (INAF), Laval University Québec, Québec, Canada., Daniel N; Québec Heart and Lung Research Institute (IUCPQ) & Institute for Nutrition and Functional Foods (INAF), Laval University Québec, Québec, Canada., Foretz M; Université de Paris, Institut Cochin, INSERM, CNRS, F-75014 Paris, France., Neunlist M; University of Nantes, INSERM, TENS, The Enteric Nervous System in Gut and Brain Diseases, IMAD, Nantes, France., Salomon BL; Sorbonne Université, INSERM, CNRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI), Paris, France., Ghosh P; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA., Marette A; Québec Heart and Lung Research Institute (IUCPQ) & Institute for Nutrition and Functional Foods (INAF), Laval University Québec, Québec, Canada., Rolli-Derkinderen M; University of Nantes, INSERM, TENS, The Enteric Nervous System in Gut and Brain Diseases, IMAD, Nantes, France. Electronic address: malvyne.derkinderen@univ-nantes.fr., Viollet B; Université de Paris, Institut Cochin, INSERM, CNRS, F-75014 Paris, France. Electronic address: benoit.viollet@inserm.fr.

Publikováno v: Molecular metabolism [Mol Metab] 2021 May; Vol. 47, pp. 101183. Date of Electronic Publication: 2021 Feb 04.