Structural colouration in Drosophila wings is thermally plastic and exhibits ecological variation

Autor: Divita Garg, Kanak Dhotre, Harshad Vijay Mayekar, Raghwinder Singh Grewal, Subhash Rajpurohit

Publikováno v: Frontiers in Ecology and Evolution, Vol 12 (2024)

IntroductionStructural colour patterns and their functions in insect wings are less known. Wing interference patterns (WIPs) are colour patterns apparent when wings are viewed against black backgrounds; the angle of incident light and wing surface st

Externí odkaz: https://doaj.org/article/61dec0d5c824425e83ff11900386db18

Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly

Autor: Pravin Kumar Ankush Jagtap, Tomáš Kubelka, Komal Soni, Cindy L. Will, Divita Garg, Claudia Sippel, Tobias G. Kapp, Harish Kumar Potukuchi, Kenji Schorpp, Kamyar Hadian, Horst Kessler, Reinhard Lührmann, Felix Hausch, Thorsten Bach, Michael Sattler

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

So far only a few compounds have been reported as splicing modulators. Here, the authors combine high-throughput screening, chemical synthesis, NMR, X-ray crystallography with functional studies and develop phenothiazines as inhibitors for the U2AF H

Externí odkaz: https://doaj.org/article/816cddccf4d4425e993bdca998fb63bd

Fruit Flies (Drosophila spp.) Collection, Handling, and Maintenance: Field to Laboratory

Autor: Pragya Topal, Divita Garg, Rajendra S. Fartyal

As drosophilids are versatile, low maintenance and non-harming model organisms, they can be easily used in all fields of life sciences like Genetics, Biotechnology, Cancer biology, Genomics, Reproductive biology, Developmental biology, Micro chemical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4574aec4d0ed872161cd01d6e70c53e1
https://doi.org/10.5772/intechopen.97014

Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly

Autor: Felix Hausch, Tobias G. Kapp, Komal Soni, Michael Sattler, Horst Kessler, Kenji Schorpp, Cindy L. Will, Divita Garg, Reinhard Lührmann, Thorsten Bach, Claudia Sippel, Kamyar Hadian, Pravin Kumar Ankush Jagtap, Harish K. Potukuchi, Tomáš Kubelka

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
'Nature Communications ', vol: 11, pages: 5621-1-5621-11 (2020)
Nat. Commun. 11:5621 (2020)

Interactions between U2AF homology motifs (UHMs) and U2AF ligand motifs (ULMs) play a crucial role in early spliceosome assembly in eukaryotic gene regulation. UHM-ULM interactions mediate heterodimerization of the constitutive splicing factors U2AF6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7c7bf8fe0cab2d397f14b562196e6e
https://mediatum.ub.tum.de/doc/1601975/document.pdf

Rational Design of Cyclic Peptide Inhibitors of U2AF Homology Motif (UHM) Domains To Modulate Pre-mRNA Splicing

Autor: Oliver Demmer, Michael Sattler, Cindy L. Will, Tobias G. Kapp, Reinhard Lührmann, Divita Garg, Horst Kessler, Pravin Kumar Ankush Jagtap

Publikováno v: Europe PubMed Central
Journal of Medicinal Chemistry
J. Med. Chem. 59, 10190-10197 (2016)

U2AF homology motifs (UHMs) are atypical RNA recognition motif domains that mediate critical protein-protein interactions during the regulation of alternative pre-mRNA splicing and other processes. The recognition of UHM domains by UHM ligand motif (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::268e7cef31b0415bcd95c01155eded1f
https://doi.org/10.1021/acs.jmedchem.6b01118