Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Diu T.T. Nguyen"'
Autor:
Meera Dhodapkar, Katerina Hoskova, James Taggart, Thomas M. Rohwetter, Saroj Gourkanti, Angela M. Savino, Ulrich Steidl, Timothy Chou, Alexendar R. Perez, Arthur Chow, Raul Rabadan, Alexandra Schurer, Justin C. Wheat, Trevor S. Barlowe, Michael G. Kharas, Christina S. Leslie, Zhaoqi Liu, Anthony Velleca, Ersilia Barin, Camila Prieto, Ly P. Vu, Diu T.T. Nguyen
Publikováno v:
Nature cancer
RNA-binding proteins (RBPs) are key arbiters of post-transcriptional regulation and are found to be dysregulated in hematological malignancies. Here we identify the RBP RNA-binding motif protein, X-linked (RBMX; also known as hnRNPG), and its retroge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d415274335668daddaa342161bbbd3fe
http://hdl.handle.net/10281/391390
http://hdl.handle.net/10281/391390
Autor:
Yuheng Lu, Saroj Gourkanti, Ly P. Vu, Alexandra Schurer, Christina S. Leslie, Payal Patel, Diu T.T. Nguyen, Sun Mi Park, Ersilia Barin, Christopher R. Chin, Camila Prieto, Angela M. Savino, Zi-ning Choo, Michael G. Kharas, Karen L. Chu, Xuejing Yang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
The cell-context dependency for RNA binding proteins (RBPs) mediated control of stem cell fate remains to be defined. Here we adapt the HyperTRIBE method using an RBP fused to a Drosophila RNA editing enzyme (ADAR) to globally map the mRNA targets of
Autor:
Christopher R. Chin, Ekaterina Kots, Jonatan Ersching, Juhee Pae, Wyatt Morgan, Chen Zhengming, George Khelashvili, Huimin Geng, Jonah Melnick, Michael G. Kharas, Amy Chadburn, Ari Melnick, Hannah M Isles, Michael Meyer-Hermann, Ersilia Barin, Matthew R. Teater, Diu T.T. Nguyen, Kenneth B. Hoehn, Arnab Bandyopadhyay, David Scott, Coraline Mlynarczyk, Ling Wang, Theinmozhi Arulraj, Muhammad H Rehman, Hui Xian Poh, Samie R. Jaffrey, Hao Shen, Gabriel D. Victora, Olivier Elemento, Ashley S. Doane
Publikováno v:
Blood. 138:359-359
Somatic missense mutations of BTG1 are exclusive to germinal center (GC)-derived B cell lymphomas (~12% of DLBCLs) and are most prevalent in ABC-DLBCL (p=0.0184 vs GCB-DLBCL), particularly in the MCD/cluster 5 subtype, which features extranodal disse
Autor:
Hanzhi Luo, Diu T.T. Nguyen, Paolo Cifani, Karen L Chu, Alex Kentsis, Ersilia Barin, Florisela Herrejon Chavez, Christina S. Leslie, Alexandra Schurer, Ly P. Vu, Alli Pine, Michael G. Kharas
Publikováno v:
Blood. 138:296-296
RNA binding proteins (RBPs) have been increasingly recognized as an important class of regulators of normal and malignant hematopoiesis. However, the exact function and underpinning mechanisms of the RBPs that govern hematopoietic stem cells (HSCs) r
Autor:
Sara Zaccara, Diu T.T. Nguyen, Minal Patel, Jessica Schulman, Brian F. Pickering, Timothy Chou, Samie R. Jaffrey, Virginia M. Klimek, Gerard Minuesa, Michael G. Kharas, Ly P. Vu, Christopher Famulare, Yogesh Saletore, Christopher E. Mason, Yuanming Cheng, Ari Melnick, Francine E. Garrett-Bakelman, Martin Carroll, Matthew MacKay, Arthur Chow
Publikováno v:
Nature Medicine. 23:1369-1376
N6-methyladenosine (m6A) is an abundant nucleotide modification in mRNA that is required for the differentiation of mouse embryonic stem cells. However, it remains unknown whether the m6A modification controls the differentiation of normal and/or mal
Autor:
Alexendar R. Perez, Ly P. Vu, James Taggart, Michael G. Kharas, Trevor Stephen Barlowe, Arthur Chow, Diu T.T. Nguyen, Zhaoqi Liu, Raul Rabadan, Alexandra Schurer, Timothy Chou, Justin C. Wheat, Ersilia Barin, Ulrich Steidl, Camila Prieto, Meera Dhodapkar, Katerina Hoskova, Saroj Gourkanti, Christina S. Leslie
Publikováno v:
Blood. 136:15-15
Mutations and aberrant expression of RNA binding proteins (RBPs) have recently been found to contribute to leukemia development (Prieto and Kharas, CSH, 2020). Previously we have identified the RBP RBMX (RNA binding motif protein, X-linked) in our sh
Autor:
Diu T.T. Nguyen, Thomas Jenuwein, Jackie Sloane-Stanley, Douglas R. Higgs, Helena Ayyub, Christian Babbs, Chris Fisher, Hsiao P.J. Voon, Barbara Xella, Jon Kerry, Nicki Gray, David Clynes, Jacqueline A. Sharpe, Caroline Scott, Sue Butler, Richard J. Gibbons
Publikováno v:
EMBO Reports
ATRX is a chromatin remodelling factor found at a wide range of tandemly repeated sequences including telomeres (TTAGGG) n . ATRX mutations are found in nearly all tumours that maintain their telomeres via the alternative lengthening of telomere (ALT
Autor:
Arthur Chow, Timothy Chou, Saroj Gourkanti, James Taggart, Ly P. Vu, Alexendar R. Perez, Camila Prieto, Michael G. Kharas, Christina S. Leslie, Trevor Stephen Barlowe, Alexandra Schurer, Diu T.T. Nguyen
Publikováno v:
Blood. 132:883-883
Acute myeloid leukemia (AML) is characterized by a block in the development of myeloid cells, often due to dysregulation of genes involved in key processes including self-renewal, proliferation, and differentiation. Somatic mutations and aberrant exp
Autor:
Diu T.T. Nguyen, Zi-ning Choo, Christopher R. Chin, Michael G. Kharas, Saroj Gourkanti, Camila Prieto, Yuheng Lu, Christina S. Leslie
Publikováno v:
Blood. 132:884-884
The RNA binding protein (RBP) MSI2 has been demonstrated to regulate the self-renewal activity and differentiation program of normal hematopoietic stem and progenitor cells (HSPCs), as well as leukemic stem cells (LSCs) (Kharas et al, Nature Medicine
Autor:
Michael G. Kharas, Diu T.T. Nguyen, Matthew MacKay, Arthur Chow, Francine Garret-Bakelman, Timothy Chou, Gerard Minuesa, Minal Patel, Ari Melnick, Ly P. Vu, Yuanming Cheng, Christopher E. Mason, Samie R. Jaffrey, Christopher Famulare, Brian F. Pickering, Martin Carroll, Zaccara Sara
Publikováno v:
Blood. 130:791-791
N 6-methyladenosine (m6A) is a nucleotide modification in mRNA that is required for the acquisition of cell fate in embryonic stem cells. Recent studies have indicated that methylation writers can act as both oncogenes and tumor suppressor genes. Her