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Akademický článek

Oxygenator assisted dynamic microphysiological culture elucidates the impact of hypoxia on valvular interstitial cell calcification

Autor: Claudia Dittfeld, Florian Schmieder, Stephan Behrens, Anett Jannasch, Klaus Matschke, Frank Sonntag, Sems-Malte Tugtekin

Publikováno v: Journal of Biological Engineering, Vol 18, Iss 1, Pp 1-14 (2024)

Abstract Introduction Microphysiological systems (MPS) offer simulation of (patho)physiological parameters. Investigation includes items which lead to fibrosis and calcification in development and progress of calcific aortic valve disease, based e.g.

Externí odkaz: https://doaj.org/article/802dbf0b3cca4177bdb170241ad7ef5f

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Akademický článek

Tissue requirements for the application of aortic valve neocuspidization – appropriate pericardium properties and homogeneity?

Autor: Claudia Dittfeld, Sophia Bähring, Cindy Welzel, Anett Jannasch, Klaus Matschke, Sems-Malte Tugtekin, Konstantin Alexiou

Publikováno v: Journal of Materials Science: Materials in Medicine, Vol 35, Iss 1, Pp 1-12 (2024)

Abstract Objective: Aortic valve neocuspidization (AVNeo) using autologous pericardium is a promising technique. Expected advantages are reduced immune response, appropriate biomechanics and lower treatment expenses. Nevertheless, autologous pericard

Externí odkaz: https://doaj.org/article/c4b467038a1e4958ad30e9548c603265

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Akademický článek

Oxygenator assisted dynamic microphysiological culture elucidates the impact of hypoxia on valvular interstitial cell calcification.

Autor: Dittfeld, Claudia¹ (AUTHOR) Claudia.Dittfeld@tu-dresden.de, Schmieder, Florian² (AUTHOR), Behrens, Stephan² (AUTHOR), Jannasch, Anett¹ (AUTHOR), Matschke, Klaus¹ (AUTHOR), Sonntag, Frank² (AUTHOR), Tugtekin, Sems-Malte¹ (AUTHOR)

Publikováno v: Journal of Biological Engineering. 8/23/2024, Vol. 18 Issue 1, p1-14. 14p.

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Akademický článek

Challenges of aortic valve tissue culture – maintenance of viability and extracellular matrix in the pulsatile dynamic microphysiological system

Autor: Claudia Dittfeld, Maximilian Winkelkotte, Anna Scheer, Emmely Voigt, Florian Schmieder, Stephan Behrens, Anett Jannasch, Klaus Matschke, Frank Sonntag, Sems-Malte Tugtekin

Publikováno v: Journal of Biological Engineering, Vol 17, Iss 1, Pp 1-19 (2023)

Abstract Background Calcific aortic valve disease (CAVD) causes an increasing health burden in the 21st century due to aging population. The complex pathophysiology remains to be understood to develop novel prevention and treatment strategies. Microp

Externí odkaz: https://doaj.org/article/d2191eea763c4b93a1315f43e65709fc

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Akademický článek

In vivo application of a glutaraldehyde-free, UVA/riboflavin cross-linked bovine pericardium confirms suitability for cardiovascular substitutes

Autor: Anett Jannasch, Cindy Welzel, Jessica Pablik, Elizabeth von Hauff, Roberta Galli, Jan Rix, Antje Schauer, Claudia Dittfeld, Sems-Malte Tugtekin

Publikováno v: APL Materials, Vol 12, Iss 1, Pp 011104-011104-13 (2024)

Glutaraldehyde (GA)-treated bovine pericardium is still the gold standard for the fabrication of bioprostheses needed for the surgical treatment of valvular malfunction. Although excellent stability and low immunogenicity are accomplished, the applic

Externí odkaz: https://doaj.org/article/1ff448dc9d54478a83178a284b5024e1

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