Muscle-Saturated Bioactive Lipids Are Increased with Aging and Influenced by High-Intensity Interval Training

Autor: Ditte Søgaard, Marcin Baranowski, Steen Larsen, Michael Taulo Lund, Cathrine Munk Scheuer, Carina Vestergaard Abildskov, Sofie Greve Dideriksen, Flemming Dela, Jørn Wulff Helge

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 5, p 1240 (2019)

Ceramide and diacylglycerol are linked to insulin resistance in rodents, but in humans the data are inconsistent. Insulin resistance is frequently observed with aging, but the role of ceramide and diacylglycerol is not clarified. Training improves me

Externí odkaz: https://doaj.org/article/0309eb6f4b6c41da9a753fbc1b93cd1a

Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise

Autor: Silas Pinto, Bruna B. Brandão, Søren Nørvang Madsen, Jørn Wulff Helge, Jessica L. O. Branquinho, Marcelo A. Mori, Beatriz Alves Guerra, Sara G. Vienberg, Steen Larsen, Jan-Wilhelm Kornfeld, Ditte Søgaard, Daniela S. Razolli, Matteo Oliverio, Atefeh Rabiee, C. Ronald Kahn, Danilo Lopes Ferrucci, Thomas Nielsen, Gabriel Palermo Ruiz, William T. Festuccia, Juleen R. Zierath, Thiago L. Knittel, Adriano S. Martins, Brice Emanuelli, Jonas T. Treebak, Josef Brandauer, Licio A. Velloso

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Brandão, B B, Madsen, S, Rabiee, A, Oliverio, M, Ruiz, G P, Ferrucci, D L, Branquinho, J L, Razolli, D, Pinto, S, Nielsen, T S, Festuccia, W T, Martins, A S, Guerra, B A, Knittel, T L, Søgaard, D, Larsen, S, Helge, J W, Brandauer, J, Velloso, L A, Emanuelli, B, Kornfeld, J W, Kahn, C R, Vienberg, S G, Zierath, J R, Treebak, J T & Mori, M A 2020, ' Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 38, pp. 23932-23941 . https://doi.org/10.1073/pnas.2011243117
Proc Natl Acad Sci U S A

DICER is a key enzyme in microRNA (miRNA) biogenesis. Here we show that aerobic exercise training up-regulates DICER in adipose tissue of mice and humans. This can be mimicked by infusion of serum from exercised mice into sedentary mice and depends o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503d7036ed09be07ad12f921a505d0ac
https://doi.org/10.1073/pnas.2011243117

The Influence of Age and Cardiorespiratory Fitness on Bioactive Lipids in Muscle

Autor: Marcin Baranowski, Flemming Dela, Ditte Søgaard, Jørn Wulff Helge

Publikováno v: The Journals of Gerontology: Series A. 74:778-786

Reduced insulin sensitivity is observed with aging and often explained by decreased physical activity. The mechanisms involved are not clarified, but bioactive lipids may play a role. We aimed to evaluate the influence of age and cardiorespiratory fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1a4b793d0cf66ec8fec3dc8a6f0bac
https://doi.org/10.1093/gerona/gly214

Aerobic and resistance exercise training reverses age‐dependent decline in NAD+ salvage capacity in human skeletal muscle

Autor: Marianne Agerholm, Jonas T. Treebak, Thomas Nielsen, Josef Brandauer, Joseph A. Houmard, Roldan M. de Guia, Leslie A. Consitt, Ditte Søgaard, Jørn Wulff Helge, Steen Larsen

Publikováno v: Physiological Reports, Vol 7, Iss 12, Pp n/a-n/a (2019)
Physiological Reports
de Guia, R M, Agerholm, M, Nielsen, T S, Consitt, L A, Sogaard, D, Helge, J W, Larsen, S, Brandauer, J, Houmard, J A & Treebak, J T 2019, ' Aerobic and resistance exercise training reverses age-dependent decline in NAD(+) salvage capacity in human skeletal muscle ', Physiological Reports, vol. 7, no. 12, e14139 . https://doi.org/10.14814/phy2.14139

Aging decreases skeletal muscle mass and strength, but aerobic and resistance exercise training maintains skeletal muscle function. NAD(+) is a coenzyme for ATP production and a required substrate for enzymes regulating cellular homeostasis. In skele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c635be9b0f43ccf992686eadeab6e8e
https://doaj.org/article/18d180cee6984cc098bf33d6be42d06c

High-intensity interval training improves insulin sensitivity in older individuals

Autor: M. S. Dehlbæk, Ditte Søgaard, Michael T. Lund, Flemming Dela, Sofie Greve Dideriksen, K. K. Christensen, Steen Larsen, C. M. Scheuer, Andreas Vigelsø, Carina Vestergaard Abildskov, Jørn Wulff Helge, Tine Lovsø Dohlmann

Publikováno v: Acta physiologica (Oxford, England). 222(4)

AIM Metabolic health may deteriorate with age as a result of altered body composition and decreased physical activity. Endurance exercise is known to counter these changes delaying or even preventing onset of metabolic diseases. High-intensity interv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4134e25c4a45972827ac91a6d7d2af6
https://pubmed.ncbi.nlm.nih.gov/29436120