Novel Antigenic Targets of HPV Therapeutic Vaccines

Autor: Ditte Rahbæk Boilesen, Karen Nørgaard Nielsen, Peter Johannes Holst

Publikováno v: Vaccines, Vol 9, Iss 11, p 1262 (2021)

Human papillomavirus (HPV) infection is the cause of the majority of cervical cancers and head and neck cancers worldwide. Although prophylactic vaccines and cervical cancer screening programs have shown efficacy in preventing HPV-associated cervical

Externí odkaz: https://doaj.org/article/86f668f39411417a8880bbb18c185db9

Data from Efficacy and Synergy with Cisplatin of an Adenovirus Vectored Therapeutic E1E2E6E7 Vaccine against HPV Genome–Positive C3 Cancers in Mice

Autor: Peter Johannes Holst, Ralf Wagner, Benedikt Asbach, Christian Thirion, Cordula Pertl, Silke Schrödel, Mikkel Dons Müller, Torsten Willert, Patrick Neckermann, Ditte Rahbæk Boilesen

Human papillomavirus (HPV) infections are the main cause of cervical and oropharyngeal cancers. As prophylactic vaccines have no curative effect, an efficient therapy would be highly desired. Most therapeutic vaccine candidates target only a small su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e3af5e14b661d64ac5a9e542fe4157
https://doi.org/10.1158/2326-6066.c.6551147.v1

The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus

Autor: Natasha A. Moussouras, Peter Johannes Holst, Brian F. Volkman, Christopher T. Veldkamp, Jeppe Malthe Mikkelsen, Zhang Yang, Frederik Vilhardt, Kristoffer L. Egerod, Katharina Lahl, Emma Probst Brandum, Mette M. Rosenkilde, Per H. Basse, Yen Hsi Chen, Christoffer K. Goth, Gertrud Malene Hjortø, Klaudia A. Orfin, Pawel Kalinski, Astrid Sissel Jørgensen, Michael B. Dwinell, Ditte Rahbæk Boilesen

Publikováno v: Jorgensen, A S, Brandum, E P, Mikkelsen, J M, Orfin, K A, Boilesen, D R, Egerod, K L, Moussouras, N A, Vilhardt, F, Kalinski, P, Basse, P, Chen, Y-H, Yang, Z, Dwinell, M B, Volkman, B F, Veldkamp, C T, Holst, P J, Lahl, K, Goth, C K, Rosenkilde, M M & Hjorto, G M 2021, ' The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus ', Cellular and Molecular Life Sciences, vol. 78, pp. 6963-6978 . https://doi.org/10.1007/s00018-021-03930-7
Cellular and Molecular Life Sciences

The endogenous chemokines CCL19 and CCL21 signal via their common receptor CCR7. CCL21 is the main lymph node homing chemokine, but a weak chemo-attractant compared to CCL19. Here we show that the 41-amino acid positively charged peptide, released th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0dd3d59f2ffef71bf371daee644900
https://curis.ku.dk/portal/da/publications/the-cterminal-peptide-of-ccl21-drastically-augments-ccl21-activity-through-the-dendritic-cell-lymph-node-homing-receptor-ccr7-by-interaction-with-the-receptor-nterminus(75fed330-7fae-4e10-a0b1-7fbac9b559e0).html

Mucosal Vaccination with Heterologous Viral Vectored Vaccine Targeting Subdominant SIV Accessory Antigens Strongly Inhibits Early Viral Replication

Autor: Alfredo Nicosia, James Blanchard, Benjamin A. H. Jensen, Ronald S. Veazey, Stefano Colloca, Jan Pravsgaard Christensen, Emeline Ragonnaud, Allan Randrup Thomsen, Anders Tolver, Antonella Folgori, Peter Johannes Holst, Ditte Rahbæk Boilesen, Huanbin Xu, Anne-Marie C. Andersson, Riccardo Cortese

Publikováno v: EBioMedicine, Vol 18, Iss C, Pp 204-215 (2017)
Xu, H, Andersson, A-M C, Ragonnaud, E, Boilesen, D, Tolver, A, Jensen, B A H, Blanchard, J L, Nicosia, A, Folgori, A, Colloca, S, Cortese, R, Thomsen, A R, Christensen, J P, Veazey, R S & Holst, P J 2017, ' Mucosal vaccination with heterologous viral vectored vaccine targeting subdominant SIV accessory antigens strongly inhibits early viral replication ', EBioMedicine, vol. 18, pp. 204–215 . https://doi.org/10.1016/j.ebiom.2017.03.003

Conventional HIV T cell vaccine strategies have not been successful in containing acute peak viremia, nor in providing long-term control. We immunized rhesus macaques intramuscularly and rectally using a heterologous adenovirus vectored SIV vaccine r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb365b9589f89b746fbf91c05d464e82
http://www.sciencedirect.com/science/article/pii/S2352396417300907