Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Dittakavi S. R. Sarma"'
Autor:
Aroon Yusuf, Dittakavi S. R. Sarma, Ramesh Vanama, Victor Ling, Janarthanan Kankesan, Prema M. Rao, Srinivasan Rajalakshmi, Jake J. Thiessen
Publikováno v:
Carcinogenesis. 25:425-430
Studies in our laboratory on the role of P-glycoprotein (Pgp, coded by mdr1 gene) have led to the hypothesis that over-expression of Pgp is closely associated with the development of cancer. It was conceived therefore that inhibitors of Pgp should in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5dd880edd6001a87c796342c0eacfc
https://doi.org/10.1093/carcin/bgh018
https://doi.org/10.1093/carcin/bgh018
Autor:
Dittakavi S. R. Sarma, Imre Farkas, A. Venket Rao, Sanjiv Agarwal, Ladislaus L. Torday, Melody L. Mak, E. Deretey, Julius Gy. Papp, Anita Agarwal, Sujatha Chakravarthi, Gregory A Chasse
Publikováno v:
Journal of Molecular Structure: THEOCHEM. 571:27-37
Lycopene is an effective antioxidant in vivo. Although lycopene is present in its all-trans isomeric form in fruits and vegetables, serum and tissue samples show a predominance of various cis-isomers of lycopene. The present study was undertaken to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d817b3959c7bea19be9cfd0d3707e5e0
https://doi.org/10.1016/s0166-1280(01)00424-9
https://doi.org/10.1016/s0166-1280(01)00424-9
Autor:
Ernest G. Seidman, Emile Levy, Ijaz A. Qureshi, Dittakavi S. R. Sarma, Serge Dionne, Frank M. Ruemmele
Publikováno v:
Cell Death & Differentiation. 6:729-735
Butyrate exerts potent anti-tumor effects by inhibiting cancer cell growth and inducing apoptosis. However, the molecular mechanisms mediating these effects remain largely unknown. Using the Caco-2 cell line, a well established model of colon cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f3bc741ffb7a2706dfc3a676bfefc3
https://doi.org/10.1038/sj.cdd.4400545
https://doi.org/10.1038/sj.cdd.4400545
Publikováno v:
Carcinogenesis. 20:1169-1175
Previously, we have shown that Copenhagen (Cop) rats are highly resistant to the induction of putative preneoplastic, glutathione S-transferase 7-7 (GST 7-7)-positive liver lesions following treatment with a modified resistant hepatocyte protocol. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193813001bb5fff9b53f710945dc5a2a
https://doi.org/10.1093/carcin/20.7.1169
https://doi.org/10.1093/carcin/20.7.1169
Publikováno v:
Molecular Carcinogenesis. 24:188-196
Our earlier studies have shown that in normal hepatocytes, orotic acid (OA) inhibits DNA synthesis induced by several growth factors in vitro and after two-thirds partial hepatectomy (PH) in vivo. As in the normal liver OA induces an imbalance in nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81c223872b48f5104ab7aad1b497634a
https://doi.org/10.1002/(sici)1098-2744(199903)24:3<188::aid-mc5>3.0.co
https://doi.org/10.1002/(sici)1098-2744(199903)24:3<188::aid-mc5>3.0.co
Autor:
Dittakavi S. R. Sarma, James E. Korkola, Geoffrey A. Wood, Valentia M. Lee, Michael C. Archer
Publikováno v:
Carcinogenesis. 18:1745-1750
Copenhagen (Cop) rats are completely resistant to the chemical induction of mammary adenocarcinomas, but their susceptibility to hepatocarcinogenesis is virtually unknown. Rat liver is a well-characterized and easily manipulated tissue in which to st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ade968f7eac3134d3336c0a9f2a4a9
https://doi.org/10.1093/carcin/18.9.1745
https://doi.org/10.1093/carcin/18.9.1745
Autor:
Paolo Pani, Sergio Laconi, Ali R. Jahangir, Ezio Laconi, Francesca Sanna, Srinivasan Rajalakshmi, Prema M. Rao, Aroon Yusuf, Antonio Monni, Dittakavi S. R. Sarma
Publikováno v:
Journal of Hepatology. 26:203-208
Background: Orotic acid (OA) is able to inhibit hepatocyte proliferation in vivo induced by 23 partial hepatectomy. The present studies were aimed at establishing: (i) whether OA also inhibits hepatocyte proliferation induced by a direct mitogen and,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d647ec6bd922c0238efb0bda592b4f10
https://doi.org/10.1016/s0168-8278(97)80027-x
https://doi.org/10.1016/s0168-8278(97)80027-x
Publikováno v:
Molecular Carcinogenesis. 10:237-245
Our earlier studies demonstrated that the beta-hydroxy-beta-methylglutaryl coenzyme A (HMG CoA) reductase gene is hypomethylated and overexpressed in hepatic nodules initiated by 1,2-dimethylhydrazine (1,2-DMH). The study presented here examined whet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb87067d7dcdc3a084471f68760c3ea1
https://doi.org/10.1002/mc.2940100408
https://doi.org/10.1002/mc.2940100408
Publikováno v:
Digestive Diseases and Sciences. 36:1294-1298
We have reported previously that orotic acid (OA), a precursor for pyrimidine nucleotide biosynthesis, is able to promote carcinogenic process in both liver and duodenum of rats. The present study investigates the possible role of mitoinhibitory effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bf199af3a53e4e94b85ce83278fb8b
https://doi.org/10.1007/bf01307525
https://doi.org/10.1007/bf01307525
Autor:
Emile Levy, Ernest G. Seidman, George Marx, Ijaz A. Qureshi, Dittakavi S. R. Sarma, S. Dionne, Marie-Josée Roy
Publikováno v:
Nutrition (Burbank, Los Angeles County, Calif.). 25(11-12)
Epidemiologic studies support an association between diet and the incidence of colorectal cancer. Butyrate, a short-chain fatty acid present in dietary fiber and dairy products, is a potential anticarcinogenic compound. We previously showed that carn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::653b655134f2d10f9c6874dae861d220
https://pubmed.ncbi.nlm.nih.gov/19619983
https://pubmed.ncbi.nlm.nih.gov/19619983