Interaction Between Sacubitril and Valsartan in Preventing Heart Failure Induced by Aortic Valve Insufficiency in Rats

Autor: Mark A. Lovich, Dita Mayer, Michael V. Orlov, Stephan Foianini, Mikhail Y. Maslov

Publikováno v: Journal of Cardiac Failure. 25:921-931

Background Synergistic interactions between neprilysin inhibition (NEPi) with sacubitril and angiotensin receptor type1 blockade (ARB) with valsartan have been implicated in improvement of left ventricular (LV) contractility, relaxation, exercise tol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13993505f52ad576aefe935a55364af
https://doi.org/10.1016/j.cardfail.2019.09.008

Genetic and epigenetic fine mapping of causal autoimmune disease variants

Autor: Dita Mayer, Charles B. Epstein, Philip L. De Jager, Marlene J. Carrasco-Alfonso, William J. Housley, Nikolaos A. Patsopoulos, Samantha Beik, Alexander A. Shishkin, Markus Kleinewietfeld, Bradley E. Bernstein, Mark J. Daly, David A. Hafler, Alexander Marson, Noam Shoresh, Kyle Kai-How Farh, C. John Luckey, Jiang Zhu, Russell J.H. Ryan, Meital Hatan, Vijay K. Kuchroo, Holly Whitton

Publikováno v: Farh, KK-H; Marson, A; Zhu, J; Kleinewietfeld, M; Housley, WJ; Beik, S; et al.(2015). Genetic and epigenetic fine mapping of causal autoimmune disease variants. NATURE, 518(7539), 337-343. doi: 10.1038/nature13835. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/8v87v60t
Nature, vol 518, iss 7539

Genome-wide association studies have identified loci underlying human diseases, but the causal nucleotide changes and mechanisms remain largely unknown. Here we developed a fine-mapping algorithm to identify candidate causal variants for 21 autoimmun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078b3f4424aaf13d331921a3096f55c1
http://www.escholarship.org/uc/item/8v87v60t