Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Disulfide-rich peptide"'
Publikováno v:
Toxins, Vol 16, Iss 1, p 55 (2024)
µ-Conotoxins are small, potent pore-blocker inhibitors of voltage-gated sodium (NaV) channels, which have been identified as pharmacological probes and putative leads for analgesic development. A limiting factor in their therapeutic development has
Externí odkaz:
https://doaj.org/article/26cd559e85ab4274bb8dcdf46263cf5d
Autor:
Gagan Sharma, Carolyne B. Braga, Kai-En Chen, Xinying Jia, Venkatraman Ramanujam, Brett M. Collins, Roberto Rittner, Mehdi Mobli
Publikováno v:
Current Research in Structural Biology, Vol 3, Iss , Pp 179-186 (2021)
Chlorotoxin (ClTx) is a 36-residue disulfide-rich peptide isolated from the venom of the scorpion Leiurus quinquestriatus. This peptide has been shown to selectively bind to brain tumours (gliomas), however, with conflicting reports regarding its dir
Externí odkaz:
https://doaj.org/article/af52d3404ddf4994b4ff881afbc923be
Autor:
Jorge Frias, Duarte Toubarro, Gro Elin Kjæreng Bjerga, Pål Puntervoll, João B. Vicente, Rui L. Reis, Nelson Simões
Publikováno v:
Toxins, Vol 14, Iss 11, p 754 (2022)
Entomopathogenic nematodes are used as biological control agents against a broad range of insect pests. We ascribed the pathogenicity of these organisms to the excretory/secretory products (ESP) released by the infective nematode. Our group character
Externí odkaz:
https://doaj.org/article/f2e28e60ce544bc08d25babc6595b1a4
Akademický článek
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Autor:
Céline Landon, Yanyu Zhu, Mainak Mustafi, Jean-Baptiste Madinier, Dominique Lelièvre, Vincent Aucagne, Agnes F. Delmas, James C. Weisshaar
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 2057 (2022)
(1) Antimicrobial peptides (AMPs) are a promising alternative to conventional antibiotics. Among AMPs, the disulfide-rich β-defensin AvBD103b, whose antibacterial activities are not inhibited by salts contrary to most other β-defensins, is particul
Externí odkaz:
https://doaj.org/article/702473fe757c4566ba897c5df6f4a5ed
Autor:
Mohadeseh Dastpeyman, Paul Giacomin, David Wilson, Matthew J. Nolan, Paramjit S. Bansal, Norelle L. Daly
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Chlorotoxin was originally isolated from the venom of the Israeli scorpion Leiurus quinquestriatus, and has potential as a tumor imaging agent based on its selective binding to tumor cells. Several targets have been suggested for chlorotoxin includin
Externí odkaz:
https://doaj.org/article/f8d8076faa2e435f889ebfca1357ffeb
Publikováno v:
Biology, Vol 4, Iss 1, Pp 161-172 (2015)
Constrained peptides are an attractive class as affinity reagents or drug leads owing to their excellent binding properties. Many kinds of these peptides, such as cyclic peptides containing disulfide bridges, are found in nature or designed artificia
Externí odkaz:
https://doaj.org/article/6269f5a1108e4b85b11c48fd2dd9bfd6
Autor:
Michael W. Pennington, Shih Chieh Chang, Satendra Chauhan, Redwan Huq, Rajeev B. Tajhya, Sandeep Chhabra, Raymond S. Norton, Christine Beeton
Publikováno v:
Marine Drugs, Vol 13, Iss 1, Pp 529-542 (2015)
ShK, from the sea anemone Stichodactyla helianthus, is a 35-residue disulfide-rich peptide that blocks the voltage-gated potassium channel Kv1.3 at ca. 10 pM and the related channel Kv1.1 at ca. 16 pM. We developed an analog of this peptide, ShK-186,
Externí odkaz:
https://doaj.org/article/c1c30af770e04c0a8a922513e4d0220d
Autor:
Sebastian Estrada-Gomez, Fernanda Caldas Cardoso, Leidy Johana Vargas-Muñoz, Juan Carlos Quintana-Castillo, Claudia Marcela Arenas Gómez, Sandy Steffany Pineda, Monica Maria Saldarriaga-Cordoba
Publikováno v:
Toxins, Vol 11, Iss 9, p 496 (2019)
Pamphobeteus verdolaga is a recently described Theraphosidae spider from the Andean region of Colombia. Previous reports partially characterized its venom profile. In this study, we conducted a detailed analysis that includes reversed-phase high-perf
Externí odkaz:
https://doaj.org/article/70122c06dccc4e31b4f6be693d5c696b
Autor:
David Wilson, Norelle L. Daly
Publikováno v:
Toxins, Vol 10, Iss 11, p 437 (2018)
Structural analysis of peptides with nuclear magnetic resonance (NMR) spectroscopy generally relies on knowledge of the primary sequence to enable assignment of the resonances prior to determination of the three-dimensional structure. Resonance assig
Externí odkaz:
https://doaj.org/article/06f072bbaaca4c1d842c2c07ded16d64