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Design, synthesis and biological evaluation of PD-1 derived peptides as inhibitors of PD-1/PD-L1 complex formation for cancer therapy

Autor: Magdalena Bojko, Katarzyna Węgrzyn, Emilia Sikorska, Mikołaj Kocikowski, Maciej Parys, Claire Battin, Peter Steinberger, Małgorzata M. Kogut, Michał Winnicki, Adam K. Sieradzan, Marta Spodzieja, Sylwia Rodziewicz-Motowidło

Publikováno v: Bojko, M, Węgrzyn, K, Sikorska, E, Kocikowski, M, Parys, M, Battin, C, Steinberger, P, Kogut, M M, Winnicki, M, Sieradzan, A K, Spodzieja, M & Rodziewicz-Motowidło, S 2022, ' Design, synthesis and biological evaluation of PD-1 derived peptides as inhibitors of PD-1/PD-L1 complex formation for cancer therapy ', Bioorganic Chemistry, vol. 128, 106047, pp. 1-15 . https://doi.org/10.1016/j.bioorg.2022.106047

Over the past few years, many molecules such as monoclonal antibodies, affibodies, nanobodies, and small compounds have been designed and tested as inhibitors of PD-1/PD-L1 complex formation. Some of them have been successfully implemented into clini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9790c9134f309a5f8bd988d48eb72b6f
https://doi.org/10.1016/j.bioorg.2022.106047

Disulfide-Linked Peptides for Blocking BTLA/HVEM Binding

Autor: Martyna Maszota-Zieleniak, Valérie Cesson, Vincent Zoete, Katarzyna Kuncewicz, Justyna Iwaszkiewicz, Adam K. Sieradzan, Agnieszka S. Karczyńska, Sylwia Rodziewicz-Motowidło, Laurent Derré, Igor Zhukov, Olivier Michielin, Katarzyna Wegrzyn, Marta Spodzieja, Daniel E. Speiser

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 2
International Journal of Molecular Sciences, Vol 21, Iss 2, p 636 (2020)
International journal of molecular sciences, vol. 21, no. 2

Immune checkpoints are crucial in the maintenance of antitumor immune responses. The activation or blockade of immune checkpoints is dependent on the interactions between receptors and ligands
such interactions can provide inhibitory or stimulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee1f991eb83aea4ab068f9d7b5f281a

Solution structure of α-conotoxin SI

Autor: David Whitford, George Barany, Balazs Hargittai, Robert W. Janes, Andrew J. Benie

Publikováno v: FEBS Letters. 476:287-295

The nuclear magnetic resonance solution structure of alpha-conotoxin SI has been determined at pH 4.2. The 36 lowest energy structures show that alpha-conotoxin SI exists in a single major solution conformation and is stabilized by six hydrogen bonds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de62120c4e58cfb51d23e3713d03f35
https://doi.org/10.1016/s0014-5793(00)01724-5

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