Probing active site chemistry in SHV beta-lactamase variants at Ambler position 244. Understanding unique properties of inhibitor resistance

Autor: Thomson, Jm, Distler, Am, Prati, Fabio, Bonomo, Ra

Publikováno v: The Journal of biological chemistry. 281(36)

Inhibitor-resistant class A beta-lactamases are an emerging threat to the use of beta-lactam/beta-lactamase inhibitor combinations (e.g. amoxicillin/clavulanate) in the treatment of serious bacterial infections. In the TEM family of Class A beta-lact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::417828ded04f83829461d85e0cc17b84
https://pubmed.ncbi.nlm.nih.gov/16803899

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N-acetyl-L-cysteine sensitizes pancreatic cancers to gemcitabine by targeting the NFκB pathway.

Autor: Qanungo S; Center for Cell Death, Injury & Regeneration, Medical University of South Carolina, Charleston 29425, SC, USA; Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, DD505 Drug Discovery Building, 70, President Street, Charleston 29425, SC, USA; Hollings Cancer Center, Medical University of South Carolina, Charleston 29425, SC, USA., Uys JD; Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston 29425, SC, USA; Hollings Cancer Center, Medical University of South Carolina, Charleston 29425, SC, USA., Manevich Y; Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston 29425, SC, USA; Hollings Cancer Center, Medical University of South Carolina, Charleston 29425, SC, USA., Distler AM; Department of Pharmacology, Case Western Reserve University, Cleveland 44106, OH, USA; Louis Stokes Veterans Affairs Medical Research Center, Cleveland 44106, OH, USA., Shaner B; Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, DD505 Drug Discovery Building, 70, President Street, Charleston 29425, SC, USA., Hill EG; Department of Public Health Sciences, Medical University of South Carolina, Charleston 29425, SC, USA; Hollings Cancer Center, Medical University of South Carolina, Charleston 29425, SC, USA., Mieyal JJ; Department of Pharmacology, Case Western Reserve University, Cleveland 44106, OH, USA; Louis Stokes Veterans Affairs Medical Research Center, Cleveland 44106, OH, USA., Lemasters JJ; Center for Cell Death, Injury & Regeneration, Medical University of South Carolina, Charleston 29425, SC, USA; Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, DD505 Drug Discovery Building, 70, President Street, Charleston 29425, SC, USA; Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston 29425, SC, USA; Hollings Cancer Center, Medical University of South Carolina, Charleston 29425, SC, USA., Townsend DM; Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, DD505 Drug Discovery Building, 70, President Street, Charleston 29425, SC, USA; Hollings Cancer Center, Medical University of South Carolina, Charleston 29425, SC, USA., Nieminen AL; Center for Cell Death, Injury & Regeneration, Medical University of South Carolina, Charleston 29425, SC, USA; Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, DD505 Drug Discovery Building, 70, President Street, Charleston 29425, SC, USA; Hollings Cancer Center, Medical University of South Carolina, Charleston 29425, SC, USA. Electronic address: nieminen@musc.edu.

Publikováno v: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2014 Sep; Vol. 68 (7), pp. 855-64. Date of Electronic Publication: 2014 Aug 28.