AIKYATAN: mapping distal regulatory elements using convolutional learning on GPU

Autor: Chih-Hao Fang, Nawanol Theera-Ampornpunt, Michael A. Roth, Ananth Grama, Somali Chaterji

Publikováno v: BMC Bioinformatics, Vol 20, Iss 1, Pp 1-17 (2019)

Abstract Background The data deluge can leverage sophisticated ML techniques for functionally annotating the regulatory non-coding genome. The challenge lies in selecting the appropriate classifier for the specific functional annotation problem, with

Externí odkaz: https://doaj.org/article/02aa026752414ec69617c939aee7594d

Epigenetic Targeting of Aberrant Transcriptional Modulation in Pancreatic Cancer

Autor: Feda H. Hamdan, Steven A. Johnsen

Publikováno v: Epigenomes, Vol 2, Iss 2, p 8 (2018)

While the mortality rates of cancer are generally declining, pancreatic cancer persists to be an exception with a 5-year-survival rate of less than 7%. Late diagnosis and resistance to conventional therapies contribute to high mortality rates in spit

Externí odkaz: https://doaj.org/article/3fe93699014b4f35a7ecd64efb3f16ba

AIKYATAN: mapping distal regulatory elements using convolutional learning on GPU

Autor: Nawanol Theera-Ampornpunt, Michael A. Roth, Ananth Grama, Chih-Hao Fang, Somali Chaterji

Publikováno v: BMC Bioinformatics
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-17 (2019)

BackgroundThe data deluge can leverage sophisticated ML techniques for functionally annotating the regulatory non-coding genome. The challenge lies in selecting the appropriate classifier for the specific functional annotation problem, within the bou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee41e30b4701fea7345e062e84788b1
http://europepmc.org/articles/PMC6781298

Investigation of transcription factor binding at distal regulatory elements

Autor: Mitchelmore, Joanna

Cellular development and function necessitate precise patterns of gene expression. Control of gene expression is in part orchestrated by a class of remote regulatory elements, termed enhancers, which are brought into contact with promoters via DNA lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95020dda2d058a35d5b9c7d60d8d9a33

Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease

Autor: Katrina, Soderquest, Arnulf, Hertweck, Claudia, Giambartolomei, Stephen, Henderson, Rami, Mohamed, Rimma, Goldberg, Esperanza, Perucha, Lude, Franke, Javier, Herrero, Vincent, Plagnol, Richard G, Jenner, Graham M, Lord

Publikováno v: PLoS Genetics, Vol 13, Iss 2, p e1006587 (2017)
Soderquest, K, Hertweck, A, Giambartolomei, C, Henderson, S, Mohamed, R, Goldberg, R, Perucha, E, Franke, L, Herrero, J, Plagnol, V, Jenner, R G & Lord, G M 2017, ' Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease ', PL o S Genetics, vol. 13, no. 2, e1006587 . https://doi.org/10.1371/journal.pgen.1006587
PLoS genetics, 13(2):e1006587. PUBLIC LIBRARY SCIENCE
Soderquest, K, Hertweck, A, Giambartolomei, C, Henderson, S, Mohamed, R, Goldberg, R, Perucha, E, Franke, L, Herrero, J, Plagnol, V, Jenner, R G & Lord, G M 2017, ' Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease ', PLoS Genetics, vol. 13, no. 2, e1006587 . https://doi.org/10.1371/journal.pgen.1006587
PLoS Genetics

The polarization of CD4+ T cells into distinct T helper cell lineages is essential for protective immunity against infection, but aberrant T cell polarization can cause autoimmunity. The transcription factor T-bet (TBX21) specifies the Th1 lineage an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::66b2e954bdddf15ac8e3e26475b92953
https://doaj.org/article/1b047c1f9aaf46738e2b7b4684f706e9