Zobrazeno 1 - 10
of 268
pro vyhledávání: '"Dissertations, UMMS"'
Autor:
Palace, Samantha G.
Publikováno v:
Morningside Graduate School of Biomedical Sciences Dissertations and Theses.
Yersinia pestis, the causative agent of plague, specializes in causing dense bacteremia following intradermal deposition of a small number of bacteria by the bite of an infected flea. This robust invasiveness requires the ability to evade containment
Externí odkaz:
https://escholarship.umassmed.edu/gsbs_diss/836
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1866&context=gsbs_diss
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1866&context=gsbs_diss
Autor:
Rooney, Timothy M.
Publikováno v:
Morningside Graduate School of Biomedical Sciences Dissertations and Theses.
Neurons comprise the main information processing cells of the nervous system. To integrate and transmit information, neurons elaborate dendritic structures to receive input and axons to relay that information to other cells. Due to their intricate st
Externí odkaz:
https://escholarship.umassmed.edu/gsbs_diss/775
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1779&context=gsbs_diss
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1779&context=gsbs_diss
Autor:
Tasdemir-Yilmaz, Ozge E.
Publikováno v:
Morningside Graduate School of Biomedical Sciences Dissertations and Theses.
The nervous system is composed of neurons and glia. Glial cells have been neglected and thought to have only a supportive role in the nervous system, even though ~60% of the mammalian brain is composed of glia. Yet, in recent years, it has been shown
Externí odkaz:
https://escholarship.umassmed.edu/gsbs_diss/729
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1727&context=gsbs_diss
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1727&context=gsbs_diss
Autor:
Bautista, Bianca L.
Publikováno v:
Morningside Graduate School of Biomedical Sciences Dissertations and Theses.
While memory CD4 T cells are critical for effective immunity to pathogens, the mechanisms underlying their generation are poorly defined. Although extensive work has been done to examine the role of antigen (Ag) in shaping memory formation, most stud
Externí odkaz:
https://escholarship.umassmed.edu/gsbs_diss/858
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1839&context=gsbs_diss
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1839&context=gsbs_diss
Autor:
Wang, Wei
Publikováno v:
Morningside Graduate School of Biomedical Sciences Dissertations and Theses.
PIWI-interacting RNAs (piRNA) are a group of 23–35 nucleotide (nt) short RNAs that protect animal gonads from transposon activities. In Drosophila germ line, piRNAs can be categorized into two different categories— primary and secondary piRNAs—
Externí odkaz:
https://escholarship.umassmed.edu/gsbs_diss/805
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1804&context=gsbs_diss
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1804&context=gsbs_diss
Autor:
Seth, Meetu
Publikováno v:
Morningside Graduate School of Biomedical Sciences Dissertations and Theses.
Organisms employ sophisticated mechanisms to silence foreign nucleic acid, such as viruses and transposons. Evidence exists for pathways that sense copy number, unpaired DNA, or aberrant RNA (e.g., dsRNA), but the mechanisms that distinguish “self
Externí odkaz:
https://escholarship.umassmed.edu/gsbs_diss/874
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1876&context=gsbs_diss
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1876&context=gsbs_diss
Autor:
Belton, Jon-Matthew
Publikováno v:
Morningside Graduate School of Biomedical Sciences Dissertations and Theses.
A hierarchy of different chromosome conformations plays a role in many biological systems. These conformations contribute to the regulation of gene expression, cellular development, chromosome transmission, and defects can lead to human disease. The
Externí odkaz:
https://escholarship.umassmed.edu/gsbs_diss/762
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1764&context=gsbs_diss
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1764&context=gsbs_diss
Autor:
DeConti, Derrick K.
Publikováno v:
Morningside Graduate School of Biomedical Sciences Dissertations and Theses.
Duplications and deletions are a major source of genomic variation. Duplications, specifically, have a significant impact on gene genesis and dosage, and the malaria parasite P. falciparum has developed resistance to a growing number of anti-malarial
Externí odkaz:
https://escholarship.umassmed.edu/gsbs_diss/869
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1871&context=gsbs_diss
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1871&context=gsbs_diss
Autor:
Costa, Matthew R.
Publikováno v:
Morningside Graduate School of Biomedical Sciences Dissertations and Theses.
Human immunodeficiency type 1 (HIV-1) is able to elicit broadly potent neutralizing antibodies in a very small subset of individuals only after several years’ infection and as a result, vaccines that elicit these types of antibodies have been diffi
Externí odkaz:
https://escholarship.umassmed.edu/gsbs_diss/866
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1868&context=gsbs_diss
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1868&context=gsbs_diss
Autor:
Kolpa, Heather J.
Publikováno v:
Morningside Graduate School of Biomedical Sciences Dissertations and Theses.
XIST RNA established the precedent for a noncoding RNA that stably associates with and regulates chromatin, however it remains poorly understood how such RNAs structurally associate with the interphase chromosome territory. I demonstrate that transge
Externí odkaz:
https://escholarship.umassmed.edu/gsbs_diss/825
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1827&context=gsbs_diss
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1827&context=gsbs_diss