Key roles of C2/GAP domains in SYNGAP1-related pathophysiology.

Autor: Katsanevaki D; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK., Till SM; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK; Centre for Brain Development and Repair, Instem, Bangalore 560065, India., Buller-Peralta I; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK., Nawaz MS; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Centre for Brain Development and Repair, Instem, Bangalore 560065, India., Louros SR; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK., Kapgal V; Centre for Brain Development and Repair, Instem, Bangalore 560065, India; The University of Transdisciplinary Health Sciences and Technology, Bangalore 560065, India., Tiwari S; Centre for Brain Development and Repair, Instem, Bangalore 560065, India., Walsh D; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK., Anstey NJ; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK; Centre for Brain Development and Repair, Instem, Bangalore 560065, India., Petrović NG; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK., Cormack A; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK., Salazar-Sanchez V; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK., Harris A; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK., Farnworth-Rowson W; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK., Sutherland A; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK., Watson TC; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK., Dimitrov S; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK., Jackson AD; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK; Centre for Brain Development and Repair, Instem, Bangalore 560065, India., Arkell D; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK., Biswal S; Centre for Brain Development and Repair, Instem, Bangalore 560065, India., Dissanayake KN; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK., Mizen LAM; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK., Perentos N; Department of Veterinary Medicine, University of Nicosia School of Veterinary Medicine, 2414 Nicosia, Cyprus., Jones MW; School of Physiology, Pharmacology, and Neuroscience, University of Bristol, Biomedical Sciences Building, University Walk, BS8 1TD Bristol, UK., Cousin MA; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK; Centre for Brain Development and Repair, Instem, Bangalore 560065, India., Booker SA; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK., Osterweil EK; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK., Chattarji S; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK; Centre for Brain Development and Repair, Instem, Bangalore 560065, India., Wyllie DJA; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK; Centre for Brain Development and Repair, Instem, Bangalore 560065, India., Gonzalez-Sulser A; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK., Hardt O; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK; Centre for Brain Development and Repair, Instem, Bangalore 560065, India; Department of Psychology, McGill University, Montreal, QC H3A 1G1, Canada., Wood ER; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK; Centre for Brain Development and Repair, Instem, Bangalore 560065, India., Kind PC; Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK; Patrick Wild Centre, University of Edinburgh, EH8 9XD Edinburgh, UK; Centre for Brain Development and Repair, Instem, Bangalore 560065, India. Electronic address: p.kind@ed.ac.uk.

Publikováno v: Cell reports [Cell Rep] 2024 Sep 24; Vol. 43 (9), pp. 114733. Date of Electronic Publication: 2024 Sep 12.

"Calcium bombs" as harbingers of synaptic pathology and their mitigation by magnesium at murine neuromuscular junctions.

Autor: Dissanayake KN; Euan MacDonald Centre for Motor Neurone Disease Research, The University of Edinburgh, Edinburgh, United Kingdom.; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom., Redman RR; Euan MacDonald Centre for Motor Neurone Disease Research, The University of Edinburgh, Edinburgh, United Kingdom.; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom., Mackenzie H; Euan MacDonald Centre for Motor Neurone Disease Research, The University of Edinburgh, Edinburgh, United Kingdom.; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom., Eddleston M; Clinical Pharmacology, Toxicology and Therapeutics, Centre for Cardiovascular Science, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom., Ribchester RR; Euan MacDonald Centre for Motor Neurone Disease Research, The University of Edinburgh, Edinburgh, United Kingdom.; Centre for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom.

Publikováno v: Frontiers in molecular neuroscience [Front Mol Neurosci] 2022 Jul 26; Vol. 15, pp. 937974. Date of Electronic Publication: 2022 Jul 26 (Print Publication: 2022).

Impaired neuromuscular function by conjoint actions of organophosphorus insecticide metabolites omethoate and cyclohexanol with implications for treatment of respiratory failure.

Autor: Dissanayake KN; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.; Pharmacology, Toxicology and Therapeutics, Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK., Chou RC; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK., Thompson A; Pharmacology, Toxicology and Therapeutics, Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK., Margetiny F; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK., Davie C; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK., McKinnon S; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK., Patel V; Department of Pharmacology, Physiology and Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ, USA., Sultatos L; Department of Pharmacology, Physiology and Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ, USA., McArdle JJ; Department of Pharmacology, Physiology and Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ, USA., Clutton RE; Wellcome Trust Critical Care Laboratory for Large Animals, Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., Eddleston M; Pharmacology, Toxicology and Therapeutics, Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK., Ribchester RR; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.

Publikováno v: Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2021 Dec; Vol. 59 (12), pp. 1239-1258. Date of Electronic Publication: 2021 May 14.

Synaptic withdrawal following nerve injury is influenced by postnatal maturity, muscle-specific properties, and the presence of underlying pathology in mice.

Autor: Mole AJ; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.; The Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh, UK., Bell S; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.; The Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh, UK., Thomson AK; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.; The Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh, UK., Dissanayake KN; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.; The Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh, UK., Ribchester RR; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.; The Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh, UK., Murray LM; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.; The Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh, UK.

Publikováno v: Journal of anatomy [J Anat] 2020 Aug; Vol. 237 (2), pp. 263-274. Date of Electronic Publication: 2020 Apr 20.

Altered mitochondrial bioenergetics are responsible for the delay in Wallerian degeneration observed in neonatal mice.

Autor: Kline RA; Centre for Discovery Brain Science, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, UK; Euan McDonald Centre for Motor Neuron Disease Research, University of Edinburgh, UK; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, EH25 9RG, UK., Dissanayake KN; Euan McDonald Centre for Motor Neuron Disease Research, University of Edinburgh, UK; Centre for Cognitive and Neural Systems, University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK., Hurtado ML; Euan McDonald Centre for Motor Neuron Disease Research, University of Edinburgh, UK; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, EH25 9RG, UK., Martínez NW; Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Santiago, Chile., Ahl A; Centre for Discovery Brain Science, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, UK., Mole AJ; Centre for Discovery Brain Science, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, UK; Euan McDonald Centre for Motor Neuron Disease Research, University of Edinburgh, UK., Lamont DJ; Fingerprints Proteomics Facility, Dundee University, Dundee DD1 4HN, United Kingdom., Court FA; Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Santiago, Chile; Geroscience Center for Brain Health and Metabolism, Santiago, Chile; The Buck Institute for Research on Aging, Novato, CA, United States., Ribchester RR; Euan McDonald Centre for Motor Neuron Disease Research, University of Edinburgh, UK; Centre for Cognitive and Neural Systems, University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK., Wishart TM; Euan McDonald Centre for Motor Neuron Disease Research, University of Edinburgh, UK; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, EH25 9RG, UK., Murray LM; Centre for Discovery Brain Science, University of Edinburgh, Hugh Robson Building, Edinburgh EH8 9XD, UK; Euan McDonald Centre for Motor Neuron Disease Research, University of Edinburgh, UK. Electronic address: Lyndsay.Murray@ed.ac.uk.

Publikováno v: Neurobiology of disease [Neurobiol Dis] 2019 Oct; Vol. 130, pp. 104496. Date of Electronic Publication: 2019 Jun 06.