Výsledky vyhledávání - "Disordered linker"

Akademický článek

Mutation in the Disordered Linker Region of Capsid Disrupts Viral Kinetics of a Neuropathogenic SIV in Rhesus Macaques

Publikováno v: Microbiology Spectrum, Vol 10, Iss 2 (2022)

ABSTRACT TRIM5α polymorphism in rhesus macaques (RM) limits the genetic pool of animals in which we can perform simian immunodeficiency virus (SIV) studies without first screening animals for permissive TRIM5α genotypes. We have previously shown th

Externí odkaz: https://doaj.org/article/4f9a43c280144aeab0b7ecf05c316e6c

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Akademický článek

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Intrinsic disorder in protein kinase A anchoring proteins signaling complexes

Autor: Mateusz Dyla, Magnus Kjaergaard

Publikováno v: Dyla, M & Kjaergaard, M 2021, Intrinsic disorder in protein kinase A anchoring proteins signaling complexes . in V N Uversky & V N Uversky (eds), Dancing Protein Clouds : Intrinsically Disordered Proteins in the Norm and Pathology, Part C . Elsevier, Amsterdam, Progress in Molecular Biology and Translational Science, vol. 183, pp. 271-294 . https://doi.org/10.1016/bs.pmbts.2021.06.005
Progress in Molecular Biology and Translational Science ISBN: 9780323852999

Protein kinase A (PKA) is regulated by a diverse class of anchoring proteins known as AKAPs that target PKA to subsets of its activators and substrates. Recently, it was reported that PKA can remain bound to its regulatory subunit after activation in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4382982f801a5af8e2137dfe488e547
https://pure.au.dk/portal/da/publications/intrinsic-disorder-in-protein-kinase-a-anchoring-proteins-signaling-complexes(b1232825-a697-40c1-96d6-84fc1a886279).html

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Predicting the effect of disordered linkers on effective concentrations and avidity with the 'Ceff calculator' app

Autor: Lucía B. Chemes, Magnus Kjaergaard, Juliana Glavina

Publikováno v: Kjaergaard, M, Glavina, J & Chemes, L B 2021, Predicting the effect of disordered linkers on effective concentrations and avidity with the “C eff calculator” app . in M Merkx (ed.), Linkers in Biomacromolecules . Academic Press, Methods in Enzymology, vol. 647, pp. 145-171 . https://doi.org/10.1016/bs.mie.2020.09.012
Linkers in Biomacromolecules ISBN: 9780128208182

Linkers are crucial to the functions of multidomain proteins as they couple functional units to encode regulation such as auto-inhibition, enzyme targeting or tuning of interaction strength. A linker changes reactions from bimolecular to unimolecular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6f0069497b94b0a23921bf613f72b49
https://pure.au.dk/portal/da/publications/predicting-the-effect-of-disordered-linkers-on-effective-concentrations-and-avidity-with-the-ceff-calculator-app(e8d7b908-d0f6-4e64-83ff-4ebbf9bcbd96).html

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