The vitamin E analog, alpha-tocopheryloxyacetic acid enhances the anti-tumor activity of trastuzumab against HER2/neu-expressing breast cancer

Autor: Tanisha Meeuwsen, Laurence H. Hurley, Emmanuel T. Akporiaye, Disis L Mary, Hailing Lu, Deborah Bradley-Dunlop, Manuel L. Penichet, Daniel D. VonHoff, David G. Besselsen, Tobias Hahn, Brook B Cole, Stephen T. Gately, Edwin B. Walker

Publikováno v: Hahn, Tobias; Bradley-Dunlop, Deborah J; Hurley, Laurence H; Von-Hoff, Daniel; Gately, Stephen; Mary, Disis L; et al.(2011). The vitamin E analog alpha-tocopheryloxyacetic acid enhances the anti-tumor activity of trastuzumab against HER2/neu-expressing breast cancer. BMC Cancer, 11(1), 471. doi: http://dx.doi.org/10.1186/1471-2407-11-471. Retrieved from: http://www.escholarship.org/uc/item/2mm6f5hj
BMC Cancer
BMC Cancer, Vol 11, Iss 1, p 471 (2011)

Background HER2/neu is an oncogene that facilitates neoplastic transformation due to its ability to transduce growth signals in a ligand-independent manner, is over-expressed in 20-30% of human breast cancers correlating with aggressive disease and h

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