Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Dishary, Sharmin"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionThe α6 subunit-containing GABAA receptors (α6GABAARs) are highly expressed in the trigeminal ganglia (TG), the sensory hub of the trigeminovascular system (TGVS). Hypo-GABAergic transmission in the TG was reported to contribute to migra
Externí odkaz:
https://doaj.org/article/9ce24f26600c4d24bc37ede64fe6fd4a
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S646- (2023)
Externí odkaz:
https://doaj.org/article/e2e5183fd6294c3abef9f383700a0dc4
Autor:
Sachiko Nakakubo, Yasuyoshi Hiramatsu, Takeru Goto, Syuhei Kimura, Masashi Narugami, Midori Nakajima, Yuki Ueda, Hideaki Shiraishi, Atsushi Manabe, Dishary Sharmin, James M. Cook, Kiyoshi Egawa
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Dravet syndrome (DS) is an intractable epilepsy syndrome concomitant with neurodevelopmental disorder that begins in infancy. DS is dominantly caused by mutations in the SCN1A gene, which encodes the α subunit of a voltage-gated Na cha
Externí odkaz:
https://doaj.org/article/39e51f6b8f474a7f94e1feaa261f66f6
Autor:
Dishary Sharmin, Md Yeunus Mian, Michael Marcotte, Thomas D. Prevot, Etienne Sibille, Jeffrey M. Witkin, James M. Cook
Publikováno v:
Molecules, Vol 28, Iss 12, p 4771 (2023)
GABA mediates inhibitory actions through various GABAA receptor subtypes, including 19 subunits in human GABAAR. Dysregulation of GABAergic neurotransmission is associated with several psychiatric disorders, including depression, anxiety, and schizop
Externí odkaz:
https://doaj.org/article/acec2607b20b4845bf8d9d92e46a9997
Autor:
Barbara Kosmowska, Martyna Paleczna, Dominika Biała, Justyna Kadłuczka, Jadwiga Wardas, Jeffrey M. Witkin, James M. Cook, Dishary Sharmin, Monika Marcinkowska, Katarzyna Z. Kuter
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 197 (2023)
Treatment of tremors, such as in essential tremor (ET) and Parkinson’s disease (PD) is mostly ineffective. Exact tremor pathomechanisms are unknown and relevant animal models are missing. GABA-A receptor is a target for tremorolytic medications, bu
Externí odkaz:
https://doaj.org/article/cca5c71e26cb420fbf6d242daa10c8b2
Autor:
Xingjie Ping, Michelle J. Meyer, Nicolas M. Zahn, Lalit K. Golani, Dishary Sharmin, Kamal P. Pandey, Sepideh Revanian, Prithu Mondal, Xiaoming Jin, Leggy A. Arnold, Rok Cerne, James M. Cook, Branka Divović, Miroslav M. Savić, Arnold Lippa, Jodi L. Smith, Jeffrey M. Witkin
Publikováno v:
Drug Development Research
A series of imidazodiazepines has been developed that possess reduced sedative liabilities but retain efficacy in anticonvulsant screening models. The latest of these compounds, (5-(8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazole[1,5-α][1,4]diazepin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd92e068ef9c959ec71ac2decf0fe410
https://doi.org/10.1002/ddr.22042
https://doi.org/10.1002/ddr.22042
Autor:
Kamal P. Pandey, Branka Divović, Farjana Rashid, Lalit K. Golani, Rok Cerne, Nicolas M. Zahn, Michelle Jean Meyer, Leggy A. Arnold, Dishary Sharmin, Md Yeunus Mian, Jodi L. Smith, Xingjie Ping, Xiaoming Jin, Arnold Lippa, V.V.N. Phani Babu Tiruveedhula, James M. Cook, Miroslav M. Savić, Jeffrey M. Witkin
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 385:50-61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79150d8e7e1712b0c4f2b466b3c9c84f
https://doi.org/10.1124/jpet.122.001362
https://doi.org/10.1124/jpet.122.001362
Autor:
Cook, Dishary Sharmin, Md Yeunus Mian, Michael Marcotte, Thomas D. Prevot, Etienne Sibille, Jeffrey M. Witkin, James M.
Publikováno v:
Molecules; Volume 28; Issue 12; Pages: 4771
GABA mediates inhibitory actions through various GABAA receptor subtypes, including 19 subunits in human GABAAR. Dysregulation of GABAergic neurotransmission is associated with several psychiatric disorders, including depression, anxiety, and schizop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::d03305460ff6816a667c06f6ebf301ae
Autor:
Stephanie Perez, Nicole Eassa, Angela Boley, Hannah Elam, Dishary Sharmin, James Cook, Daniel Lodge
Of the 35 million people in the world who suffer with Alzheimer’s Disease (AD), up to half also experience comorbid psychosis (delusions and hallucinations). Antipsychotics, used to treat symptoms of psychosis, are contraindicated in elderly patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eecf3105c924cbca85d4532cd70fe853
https://doi.org/10.21203/rs.3.rs-2809328/v1
https://doi.org/10.21203/rs.3.rs-2809328/v1
Autor:
Indu Mithra Madhuranthakam, Sarah Uribe, Danya Aldaghma, Drew Kwitchoff, Jonathan Philip, Aela A. Williams, Rohit A. Nambiar, Dishary Sharmin, James Cook, Bradford Fischer, Thomas Keck
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78229993cb6b92517b3b819ea25f030b
https://doi.org/10.1124/jpet.122.269240
https://doi.org/10.1124/jpet.122.269240