Perception of a pathogenic signature initiates intergenerational protection.

Autor: Pender CL; Department of Molecular & Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA., Dishart JG; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA., Gildea HK; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA., Nauta KM; Department of Metabolism and Nutritional Programming, Van Andel Research Institute, Grand Rapids, MI 49503, USA., Page EM; Department of Molecular & Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA., Siddiqi TF; Department of Molecular & Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA., Cheung SS; Department of Molecular & Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA., Joe L; Department of Molecular & Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA., Burton NO; Department of Metabolism and Nutritional Programming, Van Andel Research Institute, Grand Rapids, MI 49503, USA., Dillin A; Department of Molecular & Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: dillin@berkeley.edu.

Publikováno v: Cell [Cell] 2025 Feb 06; Vol. 188 (3), pp. 594-605.e10. Date of Electronic Publication: 2024 Dec 24.

Glial-derived mitochondrial signals affect neuronal proteostasis and aging.

Autor: Bar-Ziv R; Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA., Dutta N; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA., Hruby A; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA., Sukarto E; Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA., Averbukh M; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA., Alcala A; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA., Henderson HR; Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA., Durieux J; Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA., Tronnes SU; Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA., Ahmad Q; Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA., Bolas T; Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA., Perez J; Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA., Dishart JG; Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA., Vega M; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA., Garcia G; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA., Higuchi-Sanabria R; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA., Dillin A; Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley, CA 94720, USA.

Publikováno v: Science advances [Sci Adv] 2023 Oct 13; Vol. 9 (41), pp. eadi1411. Date of Electronic Publication: 2023 Oct 13.

Glia of C. elegans coordinate a protective organismal heat shock response independent of the neuronal thermosensory circuit.

Autor: Gildea HK; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Frankino PA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Tronnes SU; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Pender CL; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Durieux J; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Dishart JG; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Choi HO; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Hunter TD; Department of Biology, Howard University, Washington, DC, USA., Cheung SS; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Frakes AE; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Sukarto E; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Wickham K; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Dillin A; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.

Publikováno v: Science advances [Sci Adv] 2022 Dec 09; Vol. 8 (49), pp. eabq3970. Date of Electronic Publication: 2022 Dec 09.

Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency.

Autor: Zhang J; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; Pathology Service 113B, San Francisco VA Health Care System, San Francisco, CA, USA., Velmeshev D; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA., Hashimoto K; Department of Pathology, University of California San Francisco, San Francisco, CA, USA., Huang YH; Department of Pathology, University of California San Francisco, San Francisco, CA, USA., Hofmann JW; Department of Pathology, University of California San Francisco, San Francisco, CA, USA., Shi X; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA., Chen J; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA., Leidal AM; Department of Pathology, University of California San Francisco, San Francisco, CA, USA., Dishart JG; Department of Pathology, University of California San Francisco, San Francisco, CA, USA., Cahill MK; Neuroscience Graduate Program, University of California San Francisco, San Francisco, CA, USA.; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA., Kelley KW; Neuroscience Graduate Program, University of California San Francisco, San Francisco, CA, USA.; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA., Liddelow SA; Neuroscience Institute, Department of Neuroscience & Physiology, NYU Langone Medical Center, New York, NY, USA., Seeley WW; Neuroscience Graduate Program, University of California San Francisco, San Francisco, CA, USA.; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.; Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA., Miller BL; Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA., Walther TC; Department of Genetics and Complex Diseases, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA., Farese RV Jr; Department of Genetics and Complex Diseases, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA., Taylor JP; Department of Cell and Molecular Biology, St Jude Children's Hospital & Howard Hughes Medical Institute, Memphis, TN, USA., Ullian EM; Department of Ophthalmology, University of California San Francisco, San Francisco, CA, USA., Huang B; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA., Debnath J; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA., Wittmann T; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA.; Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, USA., Kriegstein AR; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA.; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA.; Neuroscience Graduate Program, University of California San Francisco, San Francisco, CA, USA., Huang EJ; Department of Pathology, University of California San Francisco, San Francisco, CA, USA. eric.huang2@ucsf.edu.; Pathology Service 113B, San Francisco VA Health Care System, San Francisco, CA, USA. eric.huang2@ucsf.edu.; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA. eric.huang2@ucsf.edu.; Neuroscience Graduate Program, University of California San Francisco, San Francisco, CA, USA. eric.huang2@ucsf.edu.; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA. eric.huang2@ucsf.edu.

Publikováno v: Nature [Nature] 2020 Dec; Vol. 588 (7838), pp. 459-465. Date of Electronic Publication: 2020 Aug 31.