Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Disha Malani"'
Autor:
Jarno Kivioja, Disha Malani, Ashwini Kumar, Mika Kontro, Alun Parsons, Olli Kallioniemi, Caroline A. Heckman
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract FLT3 internal tandem duplication (FLT3-ITD) is a frequent mutation in acute myeloid leukemia (AML) and remains a strong prognostic factor due to high rate of disease recurrence. Several FLT3-targeted agents have been developed, but determina
Externí odkaz:
https://doaj.org/article/b265a741e37b4d01bbabcd8866e60edf
Autor:
Brian S. White, Suleiman A. Khan, Mike J. Mason, Muhammad Ammad-ud-din, Swapnil Potdar, Disha Malani, Heikki Kuusanmäki, Brian J. Druker, Caroline Heckman, Olli Kallioniemi, Stephen E. Kurtz, Kimmo Porkka, Cristina E. Tognon, Jeffrey W. Tyner, Tero Aittokallio, Krister Wennerberg, Justin Guinney
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-11 (2021)
Abstract The FDA recently approved eight targeted therapies for acute myeloid leukemia (AML), including the BCL-2 inhibitor venetoclax. Maximizing efficacy of these treatments requires refining patient selection. To this end, we analyzed two recent A
Externí odkaz:
https://doaj.org/article/f6bd5ff98ce1490bb82d669c7207b895
Autor:
Olli Dufva, Matti Kankainen, Tiina Kelkka, Nodoka Sekiguchi, Shady Adnan Awad, Samuli Eldfors, Bhagwan Yadav, Heikki Kuusanmäki, Disha Malani, Emma I Andersson, Paavo Pietarinen, Leena Saikko, Panu E. Kovanen, Teija Ojala, Dean A. Lee, Thomas P. Loughran, Hideyuki Nakazawa, Junji Suzumiya, Ritsuro Suzuki, Young Hyeh Ko, Won Seog Kim, Shih-Sung Chuang, Tero Aittokallio, Wing C. Chan, Koichi Ohshima, Fumihiro Ishida, Satu Mustjoki
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Aggressive natural killer-cell leukemia (ANKL) has few targeted therapies. Here ANKL patients are reported to harbor STAT3, RAS-MAPK pathway, DDX3X and epigenetic modifier mutations; and drug sensitivity profiling uncovers the importance of the JAK-S
Externí odkaz:
https://doaj.org/article/a90516e221ea4f0c9791e1e130cc3ead
Autor:
Samuli Eldfors, Joseph Saad, Nemo Ikonen, Disha Malani, Bjørn Tore Gjertsen, Mika Kontro, Kimmo Porkka, Caroline A. Heckman
Monosomy 7 and del(7q) (-7/-7q) are frequent chromosomal abnormalities detected in up to 10% of acute myeloid leukemia (AML) patients. Despite unfavorable treatment outcomes, no approved targeted therapies exist for patients with -7/-7q. Therefore, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca792fb51f556a54e43d1f6004337a74
https://doi.org/10.1101/2023.04.08.23287765
https://doi.org/10.1101/2023.04.08.23287765
Autor:
Kimmo Porkka, Olli Kallioniemi, Caroline A. Heckman, Krister Wennerberg, Tero Aittokallio, Satu Mustjoki, Bjorn Tore Gjertsen, Maija Wolf, Minna Lehto, Riikka Räty, Janna Saarela, Katja Kivinen, Imre Västrik, Alun Parsons, Laura Turunen, Jani Saarela, Swapnil Potdar, Samuli Eldfors, Matti Kankainen, Olli Dufva, Heikki Kuusanmäki, Monica Hellesøy, Bhagwan Yadav, Mika Kontro, Oscar Brück, Ashwini Kumar, Disha Malani
We generated ex vivo drug-response and multiomics profiling data for a prospective series of 252 samples from 186 patients with acute myeloid leukemia (AML). A functional precision medicine tumor board (FPMTB) integrated clinical, molecular, and func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336d0fdf55697653756deb0b188488b8
https://doi.org/10.1158/2159-8290.c.6549394.v1
https://doi.org/10.1158/2159-8290.c.6549394.v1
Autor:
Kimmo Porkka, Olli Kallioniemi, Caroline A. Heckman, Krister Wennerberg, Tero Aittokallio, Satu Mustjoki, Bjorn Tore Gjertsen, Maija Wolf, Minna Lehto, Riikka Räty, Janna Saarela, Katja Kivinen, Imre Västrik, Alun Parsons, Laura Turunen, Jani Saarela, Swapnil Potdar, Samuli Eldfors, Matti Kankainen, Olli Dufva, Heikki Kuusanmäki, Monica Hellesøy, Bhagwan Yadav, Mika Kontro, Oscar Brück, Ashwini Kumar, Disha Malani
11 supplement tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9eee1ceb6573c8b675d4545fab95310
https://doi.org/10.1158/2159-8290.22540483
https://doi.org/10.1158/2159-8290.22540483
Autor:
Kimmo Porkka, Olli Kallioniemi, Caroline A. Heckman, Krister Wennerberg, Tero Aittokallio, Satu Mustjoki, Bjorn Tore Gjertsen, Maija Wolf, Minna Lehto, Riikka Räty, Janna Saarela, Katja Kivinen, Imre Västrik, Alun Parsons, Laura Turunen, Jani Saarela, Swapnil Potdar, Samuli Eldfors, Matti Kankainen, Olli Dufva, Heikki Kuusanmäki, Monica Hellesøy, Bhagwan Yadav, Mika Kontro, Oscar Brück, Ashwini Kumar, Disha Malani
Supplement text file including supplement figures, supplementary table legends and supplement methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45984f0e236d484392c15d0883c07ae
https://doi.org/10.1158/2159-8290.22540489
https://doi.org/10.1158/2159-8290.22540489
Autor:
Merja Heinäniemi, Matti Nykter, Olli Lohi, Kirsi J. Granberg, Ville Hautamäki, Patrick May, Caroline A. Heckman, Kimmo Porkka, Virva Pohjolainen, Disha Malani, Ashwini Kumar, Artturi Mäkinen, Susanna Teppo, Sergei Häyrynen, Thomas Liuksiala, Jake Lin, Juha Mehtonen, Petri Pölönen
Large collections of genome-wide data can facilitate the characterization of disease states and subtypes, permitting pan-cancer analysis of molecular phenotypes and evaluation of disease context for new therapeutic approaches. We analyzed 9,544 trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45086788d8916786b0e37935f4c27bb
https://doi.org/10.1158/0008-5472.c.6510170
https://doi.org/10.1158/0008-5472.c.6510170
Autor:
Merja Heinäniemi, Matti Nykter, Olli Lohi, Kirsi J. Granberg, Ville Hautamäki, Patrick May, Caroline A. Heckman, Kimmo Porkka, Virva Pohjolainen, Disha Malani, Ashwini Kumar, Artturi Mäkinen, Susanna Teppo, Sergei Häyrynen, Thomas Liuksiala, Jake Lin, Juha Mehtonen, Petri Pölönen
Summary of data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398801e2a876b1f5250f9e6b3131131d
https://doi.org/10.1158/0008-5472.22418585.v1
https://doi.org/10.1158/0008-5472.22418585.v1
Autor:
Merja Heinäniemi, Matti Nykter, Olli Lohi, Kirsi J. Granberg, Ville Hautamäki, Patrick May, Caroline A. Heckman, Kimmo Porkka, Virva Pohjolainen, Disha Malani, Ashwini Kumar, Artturi Mäkinen, Susanna Teppo, Sergei Häyrynen, Thomas Liuksiala, Jake Lin, Juha Mehtonen, Petri Pölönen
Supplementary Data includes Methods and Figures and Legends for Supplementary tables. Fig. S1: Sample-level quality control and pre-processing; Fig. S2: Two-dimensional representations of sample distances; Fig S3: Known vulnerabilities confirmed by H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c884a5a8316cd201e904fedba57a48
https://doi.org/10.1158/0008-5472.22418594
https://doi.org/10.1158/0008-5472.22418594