Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Disha Awasthy"'
Autor:
Pooja Agrawal, Shanmukh Katragadda, Arun K. Hariharan, Vijayashree Gauribidanur Raghavendrachar, Arunika Agarwal, Rashmi Dayalu, Disha Awasthy, Sanjay C. Sharma, Yasodha Kannan Sivasamy, P. Lakshmana, Ashwini Shanmugam, Vamsi Veeramachaneni, Vaijayanti Gupta, B. P. Vani, Lekha Subaiya, T. S. Syamala, Ramesh Hariharan, Vijay Chandru, David E. Bloom
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-11 (2021)
Abstract Background Dried blood spots (DBS) are a relatively inexpensive source of nucleic acids and are easy to collect, transport, and store in large-scale field surveys, especially in resource-limited settings. However, their performance in whole-
Externí odkaz:
https://doaj.org/article/216a8cb5bf8a47d4b2dab40f25d06195
Autor:
Agrawal, Pooja, Shanmukh Katragadda, Hariharan, Arun K., Vijayashree Gauribidanur Raghavendrachar, Arunika Agarwal, Dayalu, Rashmi, Disha Awasthy, Sharma, Sanjay C., Yasodha Kannan Sivasamy, P. Lakshmana, Ashwini Shanmugam, Vamsi Veeramachaneni, Vaijayanti Gupta, B. P. Vani, Lekha Subaiya, T. S. Syamala, Hariharan, Ramesh, Chandru, Vijay, Bloom, David E.
Additional file 3: List of heteroplasmy variants identified in subjects. The table lists the mitochondria heteroplasmy variants shortlisted in blood and DBS samples along with the %allele frequencies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db0e87a6a02858d7f57de55d9ef1e1d
Autor:
Lekha Subaiya, Ramesh Hariharan, Sanjay C Sharma, Arunika Agarwal, Rashmi Dayalu, B P Vani, Ashwini Shanmugam, Shanmukh Katragadda, Vijay Chandru, Disha Awasthy, Pooja Agrawal, Arun K Hariharan, T.S. Syamala, Vijayashree Gauribidanur Raghavendrachar, Vaijayanti Gupta, Yasodha Kannan Sivasamy, Vamsi Veeramachaneni, P Lakshmana, David E. Bloom
Publikováno v:
BMC Medical Genomics
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-11 (2021)
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-11 (2021)
BackgroundDried blood spots (DBS) are a relatively inexpensive source of nucleic acids and are easy to collect, transport, and store in large-scale field surveys, especially in resource-limited settings. However, their performance in whole-genome seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f9cab824f1f3f13445902b0bb55a84
https://pubmed.ncbi.nlm.nih.gov/33879142
https://pubmed.ncbi.nlm.nih.gov/33879142
Autor:
Disha Awasthy, Shubhada Barde, Meenakshy Venkatesh Mallya, Chandan Narayan, Vijayashree Achar
Publikováno v:
SLAS Technology. 21:423-431
This study illustrates the optimization of low-volume dispensing on a liquid handling system (LHS) to overcome the precipitation of compounds in the mammalian cytotoxicity assay with low dimethyl sulfoxide (DMSO) tolerance. All compounds at AstraZene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6629761bf9580110a8c0dcfdb9d1e525
https://doi.org/10.1177/2211068215594768
https://doi.org/10.1177/2211068215594768
Autor:
Vaishali Humnabadkar, Claire Sadler, Tanjore S. Balganesh, Prakash Vachaspati, Disha Awasthy, Manoranjan Panda, Mick D. Fellows, Parvinder Kaur, Stewart T. Cole, Florence Pojer, Vasan K. Sambandamurthy, João Neres, Sreevalli Sharma, V. Balasubramanian, Kannan Murugan, Meenakshi Mallya, Suresh Rudrapatna, Balachandra Bandodkar, Sudhir Landge, Bheemarao G. Ugarkar, Jyothi Mahadevaswamy, Kavitha Nagalapur, Amrita B. Mullick, Vasanthi Ramachandran, Anirban Ghosh, Venkita Subbulakshmi
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:7694-7710
We report the discovery of benzothiazoles, a novel anti-mycobacterial series, identified from a whole cell based screening campaign. Benzothiazoles exert their bactericidal activity against Mycobacterium tuberculosis (Mtb) through potent inhibition o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d84f5aa2e5195a52048dc8416022f28
https://doi.org/10.1016/j.bmc.2015.11.017
https://doi.org/10.1016/j.bmc.2015.11.017
Autor:
Sandesh Jatheendranath, Gayathri Balakrishnan, Sreenivasaiah Menasinakai, Sudha Ravishankar, Vasanthi Ramachandran, Sreevalli Sharma, Charles J. Eyermann, Anisha Ambady, Suresh Rudrapatna, Naina Vinay Mudugal, Disha Awasthy, Umender Sharma, Supreeth Guptha, Vasan K. Sambandamurthy, Radha Nandishaiah, Folkert Reck
Publikováno v:
Tuberculosis. 95:589-598
DNA topoisomerases perform the essential function of maintaining DNA topology in prokaryotes. DNA gyrase, an essential enzyme that introduces negative supercoils, is a clinically validated target. However, topoisomerase I (Topo I), an enzyme responsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f64cf3f22cd0b0568dbf057fdea9c4
https://doi.org/10.1016/j.tube.2015.05.004
https://doi.org/10.1016/j.tube.2015.05.004
Publikováno v:
Gene. 555:269-276
Glutamate racemase (MurI) converts l-glutamate into d-glutamate which is an essential component of peptidoglycan in bacteria. The gene encoding glutamate racemase, murI has been shown to be essential for the growth of a number of bacterial species in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9fc33efec5acdd122bbbb8207cc06ca
https://doi.org/10.1016/j.gene.2014.11.017
https://doi.org/10.1016/j.gene.2014.11.017
Publikováno v:
Gene. 550:110-116
Most bacteria are able to generate sufficient amounts of ATP from substrate level phosphorylation, thus rendering the respiratory oxidative phosphorylation non-critical. In mycobacteria, including Mycobacterium tuberculosis, ATP generation by oxidati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aba9a21a727b5f175d20bed05f3daa5
https://doi.org/10.1016/j.gene.2014.08.024
https://doi.org/10.1016/j.gene.2014.08.024
Autor:
V. K. Ramya, Vijender Panduga, Gajanan Shanbhag, Michelle Coulson, Sowmya Bharath, Vaishali Humnabadkar, Prashanti Madhavapeddi, Vasan K. Sambandamurthy, Disha Awasthy, Jim Werngren, Praveena Manjrekar, Chandan Narayan, Vijayashree Achar, Mahesh Kumar Kn, Sunita M. de Sousa, Jitendar Reddy, C. N. Naveen Kumar, Kakoli Mukherjee, Sreenivasaiah Menasinakai, Ugarkar Bheemarao, Samit Ganguly, Umender Sharma, David Waterson, Vikas Patil, Sven Hoffner, Radha Nandishaiah, Sreevalli Sharma, Shahul Hameed P, Uma Arora, Anandkumar Raichurkar, Suresh Solapure, Parvinder Kaur, Jayashree Puttur, Vikas Shinde, Murugan Chinnapattu, Suresh Rudrapatana, Sheshagiri Gaonkar, Anirban Ghosh
Publikováno v:
Journal of Medicinal Chemistry. 57:4889-4905
DNA gyrase is a clinically validated target for developing drugs against Mycobacterium tuberculosis (Mtb). Despite the promise of fluoroquinolones (FQs) as anti-tuberculosis drugs, the prevalence of pre-existing resistance to FQs is likely to restric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8505fa2cf6ba2e099b397f5538c9f37f
https://doi.org/10.1021/jm500432n
https://doi.org/10.1021/jm500432n
Publikováno v:
Microbiology. 158:319-327
Alanine racemase (Alr) is an essential enzyme in most bacteria; however, some species (e.g. Listeria monocytogenes) can utilize d-amino acid transaminase (Dat) to generate d-alanine, which renders Alr non-essential. In addition to the conflicting rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6749cd8691564f5f0764df948456164
https://doi.org/10.1099/mic.0.054064-0
https://doi.org/10.1099/mic.0.054064-0