Zobrazeno 1 - 10
of 2 501
pro vyhledávání: '"Disease-Modifying Therapies"'
Autor:
Fredrik N. Albach, Christian Geier, Christian Keicher, Maximilian G. Posch, Stephan J. Schreiber, Gerald Grütz, Levent Akyüz, Xiaodong Luo, Annaig Le-Halpere, Philippe Truffinet, Frank Wagner
Publikováno v:
Neurology and Therapy, Vol 13, Iss 6, Pp 1607-1625 (2024)
Abstract Introduction Lymphocyte depletion via anti-CD52 monoclonal antibody (mAb) therapy is an effective treatment strategy for relapsing–remitting multiple sclerosis (MS) but is associated with infusion/injection-associated reactions (IARs) and
Externí odkaz:
https://doaj.org/article/e79ea53e5efa49fd8676ff1f7d2685da
Publikováno v:
BMC Neurology, Vol 24, Iss 1, Pp 1-6 (2024)
Abstract Background Multiple Sclerosis (MS) a central nervous system autoimmune disorder, mainly affecting young adults and more prevalent among women, can lead to sexual dysfunction (SD) among both males and females with MS. Female sexual dysfunctio
Externí odkaz:
https://doaj.org/article/399be7061b774c68af16c6a54d3914ab
Autor:
Mohammed Bayounis, Mohammed Bin Mahfooz, Mohammed Assiri, Yousef Alghamdi, Fahad Alturki, Mahdi Almutairi, Abdullah Alshelawy, Mohammed Alosaimi, Faisal Almutawa, Abdulrahman Alammar, Yahya Alyahya, Osama Khojah, Seraj Makkawi, Yaser Al Malik
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
BackgroundThe potential link between disease-modifying therapies (DMTs) and malignancy in multiple sclerosis (MS) patients has generated significant concern, particularly given the immunosuppressive nature of these treatments. Conflicting evidence in
Externí odkaz:
https://doaj.org/article/6e24dea04e734bab86f688c18475b64e
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
A new diagnosis of type 1 diabetes (T1D) may be accompanied by numerous lifelong financial, emotional, and physical challenges, thus advancements in therapies that can delay the onset of clinical disease are crucial. T1D is an autoimmune condition in
Externí odkaz:
https://doaj.org/article/d629ba11f459462fb968f0d028ac2baf
Publikováno v:
Health Science Reports, Vol 7, Iss 10, Pp n/a-n/a (2024)
Abstract Background The appearance of severe acute respiratory syndrome Coronavirus 2 (SARS‐CoV‐2) initiated the COVID‐19 pandemic, resulting in millions of confirmed cases and numerous fatalities. In response, rapid vaccine development efforts
Externí odkaz:
https://doaj.org/article/514eeba17f5c4ad5b6ee61c81735835e
Autor:
Tharick A. Pascoal, Cristiano S. Aguzzoli, Firoza Z. Lussier, Lucía Crivelli, Claudia K. Suemoto, Juan Fortea, Pedro Rosa-Neto, Eduardo R. Zimmer, Pamela C.L. Ferreira, Bruna Bellaver
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105322- (2024)
Summary: Biomarkers have been instrumental in population selection and disease monitoring in clinical trials of recently FDA-approved drugs targeting amyloid-β to slow the progression of Alzheimer's disease (AD). As new therapeutic strategies and bi
Externí odkaz:
https://doaj.org/article/92d7c3ec7c0941b7b85c9899db6986c9
Autor:
Cassandra Bazile, Magdy M. Abdel Malik, Courtney Ackeifi, Randy L. Anderson, Roy W. Beck, Marc Y. Donath, Sanjoy Dutta, Joseph A. Hedrick, Stephen R. Karpen, Thomas W. H. Kay, Thomas Marder, Marjana Marinac, Jennifer McVean, Robert Meyer, Jeremy Pettus, Teresa Quattrin, Ruud H. J. Verstegen, Joshua A. Vieth, Esther Latres
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin-producing β-cells in the pancreas. This destruction leads to chronic hyperglycemia, necessitating lifelong insulin therapy to manage blood glucose levels. Typ
Externí odkaz:
https://doaj.org/article/3d839e45f08449c58283852ff8e122f0
Autor:
Clarissa M. Hoffman, Rui Tang, Saif A. Alryalat, Osama Al Deyabat, Abdul R. Alchaki, Andrew G. Lee
Publikováno v:
TNOA Journal of Ophthalmic Science and Research, Vol 62, Iss 2, Pp 137-147 (2024)
Optic neuritis (ON) is a common cause of acute visual loss due to optic neuropathy in adults. Although typical demyelinating ON usually recovers, some forms of autoimmune inflammatory ON may result in permanent disability. The relatively recent disco
Externí odkaz:
https://doaj.org/article/b8b929f905f8494286feb5e962ee5430
Publikováno v:
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, Vol 60, Iss 1, Pp 1-9 (2024)
Abstract Background Multiple sclerosis (MS) is an immune-mediated, neurodegenerative disease with devastating, disabling, and negative impacts on the patients’ quality of life (QoL). Although MS was not known in Sudan, it seems to be rising in rece
Externí odkaz:
https://doaj.org/article/eab6eabdc5354d32a685c550db7ebd47
Autor:
Iracema Leroi, Helena Dolphin, Rachel Dinh, Tony Foley, Sean Kennelly, Irina Kinchin, Rónán O’Caoimh, Sean O’Dowd, Laura O’Philbin, Susan O’Reilly, Dominic Trepel, Suzanne Timmons
Publikováno v:
BMC Health Services Research, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background A new class of antibody-based drug therapy with the potential for disease modification is now available for Alzheimer’s disease (AD). However, the complexity of drug eligibility, administration, cost, and safety of such disease
Externí odkaz:
https://doaj.org/article/9e3b3a3641554532b2c94fa002ce8e9d