Zobrazeno 1 - 10
of 2 824
pro vyhledávání: '"Disease pathogenesis"'
Publikováno v:
Non-coding RNA Research, Vol 9, Iss 2, Pp 447-462 (2024)
The discovery of non-coding RNAs (ncRNAs) has unveiled a wide range of transcripts that do not encode proteins but play key roles in several cellular and molecular processes. Long noncoding RNAs (lncRNAs) are specific class of ncRNAs that are longer
Externí odkaz:
https://doaj.org/article/64511dc8109347faa75c4412681dfc41
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-13 (2024)
Abstract Alpha-synuclein (αsyn) is an intrinsically disordered protein that aggregates in the brain in several neurodegenerative diseases collectively called synucleinopathies. Phosphorylation of αsyn at serine 129 (PSER129) was considered rare in
Externí odkaz:
https://doaj.org/article/a81cab8e30a24d71b7ad9055905be9fb
Publikováno v:
Pharmacological Research, Vol 205, Iss , Pp 107222- (2024)
5-methylcytosine (m5C) is among the most common epigenetic modification in DNA and RNA molecules, and plays an important role in the animal development and disease pathogenesis. Interestingly, unlike other m5C DNA methyltransferases (DNMTs), DNMT2/TR
Externí odkaz:
https://doaj.org/article/15ad576ea4f74b5187db723b84f0f459
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract We describe a multidisciplinary teamwork approach known as “Operation IDD Gene Team” developed by the Rose F. Kennedy Intellectual and Developmental Disabilities Research Center (RFK IDDRC) at the Albert Einstein College of Medicine. Thi
Externí odkaz:
https://doaj.org/article/58dfd706e5b94bcc80a678e69e80ca78
Exploring the multifaceted role of GCN1: Implications in cellular responses and disease pathogenesis
Autor:
Xinying Zheng, Jinze Shen, Hongting Jiang, Mei Tian, Qurui Wang, Kailin Guo, Ruixiu Chen, Qing Xia, Qibin Yan, Lihua Du, Shiwei Duan
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116681- (2024)
GCN1 is a highly conserved protein present widely across eukaryotes. As an upstream activator of protein kinase GCN2, GCN1 plays a pivotal role in integrated stress responses, such as amino acid starvation and oxidative stress. Through interaction wi
Externí odkaz:
https://doaj.org/article/6b7b1923ac36428e9bb0820f897650b8