The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia

Autor: John Blaikley, Gareth B. Kitchen, Tracy Hussell, Mudassar Iqbal, Robert Maidstone, Laura Matthews, Hannah J. Durrington, Peter S. Cunningham, James Bagnall, Nicola Begley, Matthew Baxter, Ben Saer, Toryn Poolman, Julie E. Gibbs, Andrew S. I. Loudon, David W. Ray, David H. Dockrell

Publikováno v: Kitchen, G B, Cunningham, P S, Poolman, T M, Iqbal, M, Maidstone, R, Baxter, M, Bagnall, J, Begley, N, Saer, B, Hussell, T, Matthews, L C, Dockrell, D H, Durrington, H J, Gibbs, J E, Blaikley, J F, Loudon, A S & Ray, D W 2020, ' The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia ', Proceedings of the National Academy of Sciences, vol. 117, no. 3, pp. 1543-1551 . https://doi.org/10.1073/pnas.1915932117

The circadian clock regulates many aspects of immunity. Bacterial infections are affected by time of day, but the mechanisms involved remain undefined. Here we show that loss of the core clock protein BMAL1 in macrophages confers protection against p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2f3ec07d41a024bb148b8e2b4eb0d7
https://doi.org/10.1073/pnas.1915932117

Host interactors of effector proteins of the lettuce downy mildew Bremia lactucae obtained by yeast two-hybrid screening

Autor: Pelgrom, Alexandra J E, Meisrimler, Claudia-Nicole, Elberse, Joyce, Koorman, Thijs, Boxem, Mike, Van den Ackerveken, Guido, Sub Plant-Microbe Interactions, Sub Developmental Biology, Plant Microbe Interactions, Developmental Biology

Publikováno v: PLoS ONE, Vol 15, Iss 5, p e0226540 (2020)
PLoS One, 15(5). Public Library of Science
PLoS ONE

Plant pathogenic bacteria, fungi and oomycetes secrete effector proteins to manipulate host cell processes to establish a successful infection. Over the last decade the genomes and transcriptomes of many agriculturally important plant pathogens have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33708458e266262f627c7d14ff1ab85
https://dspace.library.uu.nl/handle/1874/409815

Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections

Autor: Ciarlo, Eleonora, Heinonen, Tytti, Lugrin, Jerome, Acha-Orbea, Hans, Le Roy, Didier, Auwerx, Johan, Roger, Thierry

Publikováno v: Scientific reports, vol. 7, no. 1, pp. 3853
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)

Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase. SIRT3 regulates cell metabolism and redox homeostasis, and protects from aging and age-associated pathologies. SIRT3 may drive both oncogenic and tumor-suppressive effects. SIRT3 deficiency has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f50ce9b5c1368e584e9197b0db37cefa
https://serval.unil.ch/resource/serval:BIB_CE9836DB152C.P001/REF.pdf

Mining the natural genetic variation in Arabidopsis thaliana for adaptation to sequential abiotic and biotic stresses

Autor: Coolen, Silvia, Van Pelt, Johan A, Van Wees, Saskia C M, Pieterse, Corné M J, Sub Plant-Microbe Interactions, Plant Microbe Interactions

Publikováno v: Planta, 249(4), 1087. Springer Verlag

In this genome-wide association study, we obtained novel insights into the genetic basis of the effect of herbivory or drought stress on the level of resistance against the fungus Botrytis cinerea. In nature, plants function in complex environments w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::909e91200de4afbfde06d5a9ac0f49f2
https://hdl.handle.net/1874/386943

A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A

Autor: Brigit Brand, Alessandro Gringeri, Paul Giangrande, James J. Goedert, Michael Recht, Olga Katsarou, Ana Rosa Cid-Haro, Patrick F. Fogarty, Steven M. Wolinsky, Evelien P. Mauser-Bunschoten, Judith Lin, Kate Talks, Javier Martinez-Picado, Amy D. Shapiro, Amalio Telenti, Christine L. Kempton, Lucy Dorrell, David Goldstein, Jérôme Lane, Jerry S. Powell, Sara Colombo, Judith Dalmau, Jeremy J. Martinson, Johannes Oldenburg, Shehnaz K. Hussain, Barton F. Haynes, Michael Makris, Dimitrios A. Tsakiris, Amanda Stemke, Anne T. Neff, Stephen Moore, Shinichi Oka, Philip Kuriakose, Rathi V. Iyer, Jonathan T. Wilde, Peter William Collins, Maria Teresa Alvarez-Roman, Andrew J. McMichael, Rafael Parra, Françoise Boehlen, Paul J. McLaren, Deborah L Brown, Marilyn J. Manco-Johnson, Thynn Thynn Yee, Kimo C. Stine, Bonaventura Clotet, Kimberly Pelak, Jay H. Bream, Kristiina Peter-Salonen, Paula H B Bolton-Maggs, Elaine Y. Chiang, Lisa P. Jacobson, Mary Carrington, Lara Oyesiku, Anne Angelillo-Scherrer, Jacques Fellay, Kevin V. Shianna

Publikováno v: Lane, Jérôme; McLaren, Paul J.; Dorrell, Lucy; Shianna, Kevin V.; Stemke, Amanda; Pelak, Kimberly; Moore, Stephen; Oldenburg, Johannes; Boehlen, Francoise; Alvarez-Roman, Maria Teresa; Angelillo-Scherrer, Anne; Bolton-Maggs, Paula H. B.; Brand, Brigit; Brown, Deborah; Chiang, Elaine; Cid-Haro, Ana Rosa; Clotet, Bonaventura; Collins, Peter; Colombo, Sara; Dalmau, Judith; ... (2013). A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A. Human molecular genetics, 22(9), pp. 1903-1910. Oxford University Press 10.1093/hmg/ddt033
Human Molecular Genetics, Vol. 22, No 9 (2013) pp. 1903-1910
Human molecular genetics
Human Molecular Genetics, vol. 22, no. 9, pp. 1903-1910

Human genetic variation contributes to differences in susceptibility to HIV-1 infection. To search for novel host resistance factors, we performed a genome-wide association study (GWAS) in hemophilia patients highly exposed to potentially contaminate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d1c24750bfdac52d92b3d5e567a3f03
https://doi.org/10.1093/hmg/ddt033